Imfinzi

Uses of Imfinzi

Imfinzi (durvalumab) is a cancer immunotherapy that may increase overall survival, lower the chance of cancer spreading, and help shrink tumors, depending on the type of cancer. It works by helping the immune system find, recognize, and fight cancer cells.

Imfinzi is used to treat types of non-small cell lung cancer (NSCLC), extensive-stage small cell lung cancer (ES-SCLC), bile ducts and gallbladder cancer, unresectable hepatocellular carcinoma and advanced or recurrent dMMR endometrial cancer.

Imfinzi is given as an infusion into a vein every 2, 3, or 4 weeks, depending on your condition. Other medicines may be part of your treatment plan, depending on your cancer type.

Precautions and Warnings

Imfinzi works by causing your immune system to attack tumor cells but it may also cause your immune system to attack healthy organs and tissues in your body. This could lead to serious or life-threatening side effects on your lungs, liver, pancreas, kidneys, intestines, thyroid, pituitary, or adrenal glands.

Call your doctor at once if you have new or unusual symptoms, such as: tiredness, mood changes, headaches, vision problems, muscle weakness, stomach problems, weight changes, skin rash, hair loss, bleeding or bruising, yellowing of your skin or eyes, increased or decreased urination, dark urine, bloody or tarry stools, worsening cough, chest pain, or trouble breathing.

Infusion-Related Reactions. Your infusion may be slowed, interrupted or permanently discontinued if you have an infusion-related reaction, depending on the severity of the reaction.

Complications of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT). Fatal and other serious complications can occur in patients who receive allogeneic HSCT before or after being treated with a PD-1/PD-L1 blocking antibody.

Embryo-Fetal Toxicity: This medicine can cause fetal harm. Females of reproductive potential should be advised of the potential risk to a fetus and should use effective contraception.

Do not breastfeed while using medicine, and for at least 3 months after your last dose.

Dosage

The Imfinzi dosage your doctor prescribes will depend on several factors. These include:

• the type of cancer being treated
• your body weight in kilograms (kg)
• other medical conditions you may have
• whether you have certain side effects

Your doctor will determine the best dosage to fit your needs. Your doctor can also give you dosage information on any drugs you need to take in combination with Imfinzi.

Side Effects

Common side effects:

• Tiredness,
• loss of appetite,
• nausea,
• constipation,
• muscle/bone pain,
• swelling hands/ankles/feet