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Cresemba

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Cresemba (isavuconazonium sulfate) is a prescription antifungal medication used to treat serious fungal infections, including invasive aspergillosis and invasive mucormycosis. It is a prodrug that is rapidly converted in the body to isavuconazole, which inhibits the synthesis of fungal cell membranes, leading to fungal cell death.

Benefits

  • Effective against life-threatening fungal infections such as aspergillosis and mucormycosis
  • Broad-spectrum activity against a wide range of yeasts and molds
  • Available in both oral and intravenous formulations for flexible treatment
  • Generally better tolerated than older antifungal agents like amphotericin B
  • Suitable for long-term treatment when necessary

Dosage

  • Typical loading dose: 372 mg (equivalent to 200 mg isavuconazole) every 8 hours for 6 doses
  • Maintenance dose: 372 mg once daily starting 12–24 hours after the last loading dose
  • Can be taken orally (capsules) or intravenously — interchangeable formulations
  • Capsules should be swallowed whole, with or without food
  • Duration of therapy depends on the type and severity of infection — follow medical guidance

Warnings and Precautions

  • May cause liver toxicity — monitor liver function tests regularly
  • Use with caution in patients with known cardiac issues; Cresemba may shorten the QT interval
  • Not recommended for use with strong CYP3A4 inducers or inhibitors due to interaction risk
  • Use in pregnancy only if clearly needed; may cause fetal harm
  • Safety in breastfeeding is not established — consult a healthcare provider
  • Not indicated for fungal infections that are less severe or self-limiting

Usage Instructions

  • Take at the same time each day for consistent blood levels
  • Do not crush or open the capsules
  • Follow the full prescribed course even if symptoms improve early
  • Inform your doctor of all other medications, especially those metabolized by the liver
  • Regular blood tests may be required to monitor for side effects and effectiveness

Storage Information

  • Store capsules at 20–25°C (68–77°F)
  • Protect from moisture and light
  • IV formulation should be stored and handled by a healthcare professional
  • Keep out of reach of children

Side Effects

  • Common: nausea, vomiting, diarrhea, headache, cough, fatigue, low potassium (hypokalemia)
  • Liver: elevated liver enzymes, jaundice (yellowing of skin/eyes)
  • Skin: rash, itching
  • Blood: anemia, low white blood cell count
  • Serious (seek medical help): signs of liver damage (dark urine, abdominal pain), allergic reactions (swelling, rash, difficulty breathing), severe dizziness, or irregular heartbeat

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Rewards Program

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POINT VALUE

100 points
1 USD

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