Cresemba

Cresemba (isavuconazonium sulfate) is a prescription antifungal medication used to treat serious fungal infections, including invasive aspergillosis and invasive mucormycosis. It is a prodrug that is rapidly converted in the body to isavuconazole, which inhibits the synthesis of fungal cell membranes, leading to fungal cell death.

Benefits

• Effective against life-threatening fungal infections such as aspergillosis and mucormycosis
• Broad-spectrum activity against a wide range of yeasts and molds
• Available in both oral and intravenous formulations for flexible treatment
• Generally better tolerated than older antifungal agents like amphotericin B
• Suitable for long-term treatment when necessary

Dosage

• Typical loading dose: 372 mg (equivalent to 200 mg isavuconazole) every 8 hours for 6 doses
• Maintenance dose: 372 mg once daily starting 12–24 hours after the last loading dose
• Can be taken orally (capsules) or intravenously — interchangeable formulations
• Capsules should be swallowed whole, with or without food
• Duration of therapy depends on the type and severity of infection — follow medical guidance

Warnings and Precautions

• May cause liver toxicity — monitor liver function tests regularly
• Use with caution in patients with known cardiac issues; Cresemba may shorten the QT interval
• Not recommended for use with strong CYP3A4 inducers or inhibitors due to interaction risk
• Use in pregnancy only if clearly needed; may cause fetal harm
• Safety in breastfeeding is not established — consult a healthcare provider
• Not indicated for fungal infections that are less severe or self-limiting

Usage Instructions

• Take at the same time each day for consistent blood levels
• Do not crush or open the capsules
• Follow the full prescribed course even if symptoms improve early
• Inform your doctor of all other medications, especially those metabolized by the liver
• Regular blood tests may be required to monitor for side effects and effectiveness

Storage Information

• Store capsules at 20–25°C (68–77°F)
• Protect from moisture and light
• IV formulation should be stored and handled by a healthcare professional
• Keep out of reach of children

Side Effects

• Common: nausea, vomiting, diarrhea, headache, cough, fatigue, low potassium (hypokalemia)
• Liver: elevated liver enzymes, jaundice (yellowing of skin/eyes)
• Skin: rash, itching
• Blood: anemia, low white blood cell count
• Serious (seek medical help): signs of liver damage (dark urine, abdominal pain), allergic reactions (swelling, rash, difficulty breathing), severe dizziness, or irregular heartbeat