Select Language:
Book Online Doctor Visit

Is it safe to take alcohol with Wellbutrin

Post written by BFH Staff Writer on October 19, 2023
Share Post:
Wellbutrin and Alcohol
Navigate Post

Wellbutrin, also known by its generic name bupropion, is a medication commonly prescribed to treat depression and assist with smoking cessation. It works by affecting certain chemicals in the brain that play a role in mood regulation. While Wellbutrin can effectively manage these conditions, questions often arise about its compatibility with alcohol consumption.

What is Wellbutrin?

Before we delve into the interaction between Wellbutrin and alcohol, it’s crucial to understand how Wellbutrin works. Experts classify Wellbutrin as an atypical antidepressant and differs from many other antidepressants as it does not belong to the selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) classes. Instead, it primarily affects norepinephrine and dopamine levels in the brain.

What are the Risks of Mixing Wellbutrin and Alcohol?

Increased Risk of Seizures

The risk of seizures is perhaps the most critical concern when considering the combination of Wellbutrin and alcohol. Both substances independently lower the seizure threshold, which is the point at which a seizure can occur in the brain. When these two factors are together, the risk of experiencing a seizure becomes significantly higher. Seizures are neurological events ranging from mild to severe and might be life-threatening. While seizures are relatively rare occurrences, we should not underestimate the risk.

●    Mechanism – Wellbutrin affects norepinephrine and dopamine levels in the brain. These neurotransmitters play a role in seizure regulation. Alcohol, on the other hand, involves the GABA (gamma-aminobutyric acid) system, which can also influence seizure thresholds. When taken together, the combined impact on these systems can disrupt the brain’s delicate balance and trigger seizures in some individuals.

Enhanced Side Effects

When Wellbutrin and alcohol are combined, the potential for side effects becomes more pronounced and uncomfortable. Some common side effects of Wellbutrin include:

●    Dizziness – Both Wellbutrin and alcohol can independently cause dizziness. When used together, this sensation of unsteadiness can become more intense and unpleasant.

●    Drowsiness – Wellbutrin may cause drowsiness or fatigue in some individuals. Alcohol, a depressant, can exacerbate these feelings of tiredness, potentially leading to increased sedation.

●    Increased Heart Rate – Wellbutrin can stimulate the cardiovascular system, leading to an increased heart rate or palpitations in some people. Alcohol, when consumed in excess, can also elevate heart rate. Combining these substances can intensify these cardiac effects, which may be uncomfortable or concerning for those with heart conditions.

Alcohol’s Impact on Mental Health

Alcohol is classified as a depressant, slowing down the central nervous system. While it may initially provide a temporary sense of relaxation or relief from anxiety, its long-term use can negatively affect mental health, particularly for individuals with conditions like depression and anxiety. Consuming alcohol alongside Wellbutrin can counteract the medication’s positive effects.

●    Depression and Anxiety – Alcohol can exacerbate symptoms of depression and anxiety. This happens because alcohol disrupts the balance of neurotransmitters in the brain, including serotonin and dopamine, which are key players in regulating mood. Over time, alcohol can lead to increased sadness, hopelessness, and anxiety, undermining the therapeutic effects of Wellbutrin.

Precautions for Safe Use of Wellbutrin

If you are taking Wellbutrin and considering consuming alcohol, it’s essential to proceed with caution and follow these guidelines:

Consult Your Healthcare Provider

Always consult your healthcare provider before drinking alcohol while on Wellbutrin. Your doctor knows your medical history and can provide personalized advice based on your circumstances.

Limit Alcohol Intake

If your healthcare provider approves occasional alcohol consumption, do so in moderation. Limit yourself to one drink or less daily, as health guidelines define.

Know Your Limit

Understand your tolerance for alcohol. Some individuals may experience increased sensitivity to alcohol while taking Wellbutrin, so monitoring your reactions is crucial.

Monitor Side Effects

Pay attention to any adverse reactions or increased side effects when combining Wellbutrin and alcohol. Seek immediate medical attention if you experience severe dizziness, rapid heart rate, or unusual symptoms.

Avoid Heavy Drinking

Avoid binge drinking or heavy alcohol consumption while on Wellbutrin. Excessive alcohol intake can significantly increase the risks associated with this combination.


While it is not strictly forbidden to consume alcohol while taking Wellbutrin, it is essential to approach this combination with caution. Mixing Wellbutrin and alcohol can increase the risk of seizures and enhance side effects. To ensure your safety and the effectiveness of your Wellbutrin treatment, always consult your healthcare provider before consuming alcohol and follow their guidance. They may often recommend abstaining from alcohol altogether to prioritize your well-being. Remember, your health should always be the top priority, and responsible decision-making is crucial when managing your mental health with medication.

Related Products

There are no related matching items at this time. Please check again soon.