Select Language:
Book Online Doctor Visit

Can I Take Trazodone And Wellbutrin Together: A Comprehensive Guide

Post written by BFH Staff Writer on February 16, 2024
Share Post:
wellbutrin and trazodone combination side effects
Navigate Post

If you have ever wondered taking Trazodone and Wellbutrin together, you’re not alone. Many individuals facing depression, anxiety, or sleep disturbances contemplate the potential benefits and risks of mixing these medications.

In this guide, we’ll delve into the safety considerations, potential interactions, andd essential insights to equip you with the knowledge needed to make informed decisions about your mental health care. Whether you’re exploring treatment options or seeking clarity on an existing regimen, this guide aims to illuminate the path forward, empowering you to navigate your medication journey with confidence and clarity.

Understanding Trazodone and Wellbutrin

What is Trazodone?

Trazodone is primarily prescribed to treat depression, anxiety disorders, and insomnia. It belongs to the class of drugs known as serotonin antagonist and reuptake inhibitors (SARIs), which work by increasing serotonin levels in the brain. Its sedative properties make it a popular choice for addressing sleep disturbances associated with depression and anxiety.

What is Wellbutrin?

Wellbutrin, also known by its generic name bupropion, is an antidepressant medication that primarily targets dopamine and norepinephrine in the brain. It’s commonly used to treat major depressive disorder and seasonal affective disorder. Unlike many other antidepressants, Wellbutrin is less likely to cause sexual dysfunction and weight gain, making it a preferred option for some individuals.

Wellbutrin and Trazodone Combination Side Effects

While both Trazodone and Wellbutrin are effective in treating depression, they affect different neurotransmitters in the brain. When considering taking them together, it’s crucial to understand potential interactions:

  1. Serotonin Syndrome Risk – Combining medications that increase serotonin levels, such as Trazodone and Wellbutrin, can potentially lead to serotonin syndrome—a rare but serious condition characterized by symptoms like agitation, confusion, rapid heart rate, and high blood pressure. However, the risk is relatively low when these medications are prescribed within therapeutic doses and under medical supervision.
  2. Increased Sedation – Since both Trazodone and Wellbutrin can cause drowsiness, combining them may amplify this side effect. Individuals taking these medications together should be cautious when engaging in activities requiring mental alertness, such as driving or operating machinery.
  3. Seizure Risk – Wellbutrin carries a warning regarding the risk of seizures, especially at higher doses. While Trazodone is not associated with an increased risk of seizures, combining it with Wellbutrin may elevate this risk, particularly in individuals with a history of seizures or predisposing factors.

Can You Take Trazodone and Wellbutrin Together?

Despite the potential risks mentioned, some individuals may benefit from combining Trazodone and Wellbutrin under careful medical supervision. Healthcare providers may adjust dosages, monitor for adverse effects, and provide guidance based on individual needs and medical history.

Ultimately, the decision to take Trazodone and Wellbutrin together should be made in consultation with a healthcare provider. They can evaluate your specific circumstances, weigh the potential risks and benefits, and tailor a treatment plan that maximizes effectiveness while minimizing adverse effects. Open communication with your healthcare provider is crucial for optimizing your mental health treatment and ensuring safety when considering medication combinations.

Can I Take Wellbutrin in the Morning and Trazodone at Night?

Generally speaking, it is possible to take Wellbutrin in the morning and Trazodone at night.

Wellbutrin is often prescribed to be taken in the morning because it can be stimulating for some individuals and may interfere with sleep if taken too late in the day. On the other hand, Trazodone is commonly used as a sleep aid due to its sedating effects and is typically taken at bedtime.

Your doctor will consider various factors such as your medical history, current medications, and specific health needs before recommending this combination or making any adjustments to your medication regimen.

Wellbutrin and Trazodone For Sleep

While Wellbutrin is not typically prescribed as a primary medication for sleep disorders, Trazodone is commonly used off-label as a sleep aid due to its sedating effects. However, prescribing practices can vary depending on individual circumstances and the judgment of healthcare professionals.


While Trazodone and Wellbutrin can be effective treatments for depression and other mental health conditions, combining them requires careful consideration and medical supervision. Potential interactions and risks, including serotonin syndrome and increased sedation, highlight the importance of consulting with a healthcare provider before initiating or modifying treatment. With proper guidance and monitoring, some individuals may find relief from their symptoms through the combined use of Trazodone and Wellbutrin. However, individual responses can vary, underscoring the need for personalized medical advice in managing mental health concerns.

Related Products



  • In Stock
  • Express Shipping
  • Bulk Discounts
Select options This product has multiple variants. The options may be chosen on the product page


  • In Stock
  • Express Shipping
  • Bulk Discounts
Select options This product has multiple variants. The options may be chosen on the product page
Lotemax Ophthalmic Ointment


  • In Stock
  • Express Shipping
  • Bulk Discounts
Select options This product has multiple variants. The options may be chosen on the product page
Lotemax Ophthalmic Gel


  • In Stock
  • Express Shipping
  • Bulk Discounts
Select options This product has multiple variants. The options may be chosen on the product page