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Ibrance
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Ibrance (palbociclib) is a targeted therapy used to treat certain types of breast cancer, particularly hormone receptor-positive (HR+) and HER2-negative metastatic breast cancer.
Benefits:
- It slows the growth of cancer cells by inhibiting CDK4/6 proteins.
- Used in combination with hormone therapy for enhanced effectiveness.
- It helps delay cancer progression and improves survival rates.
Dosage:
- Typically taken once daily for 21 days, followed by a 7-day break.
- Dosage varies based on individual response and tolerability.
Warnings and Precautions:
- It can lower white blood cell counts, increasing infection risk.
- It may cause fatigue and nausea.
- Not recommended during pregnancy.
Usage Instructions:
- Take with food at the same time each day.
- Swallow capsules are whole; do not crush or open.
- Avoid grapefruit and grapefruit juice.
Storage Information:
- Store at room temperature, away from heat and moisture.
Common Side Effects:
- Mild: Fatigue, nausea, diarrhea, hair thinning.
- Severe: Low white blood cell count, fever, breathing difficulties (seek immediate medical care).
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- Worldwide (excludes some countries***)
What is Ibrance used for?
Ibrance (palbociclib) is a targeted cancer therapy used to treat hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. It is commonly prescribed alongside hormone therapy such as letrozole or fulvestrant.
How does Ibrance work?
Ibrance inhibits cyclin-dependent kinases 4 and 6 (CDK4/6), proteins that help cancer cells divide and grow. By blocking these enzymes, it slows the progression of the cancer.
What is the dosing schedule for Ibrance?
Ibrance is typically taken in a 21-days-on, 7-days-off cycle. The dose is usually one capsule daily with food. Adherence to the dosing schedule is crucial for treatment effectiveness.
What side effects are associated with Ibrance?
Common side effects include fatigue, low white blood cell counts (neutropenia), nausea, infections, and hair thinning. Blood counts must be monitored regularly during treatment.
Can Ibrance be taken with other medications or supplements?
Ibrance can interact with several medications, especially those that affect liver enzymes (like CYP3A4 inhibitors/inducers). Grapefruit and grapefruit juice should also be avoided.
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