Ibrance® Capsules for HR+ HER2‑Negative Breast Cancer

Ibrance is a prescription CDK4/6 inhibitor used for HR+ HER2‑negative advanced breast cancer. This page explains how it works, safety basics, and how you can order with US delivery from Canada. We also outline ways to lower costs without insurance.

What Ibrance Is and How It Works

Ibrance® contains palbociclib, a cyclin‑dependent kinase 4 and 6 inhibitor. It helps slow the growth of hormone receptor–positive breast cancer cells. Clinicians use it with an aromatase inhibitor as initial endocrine therapy, or with fulvestrant after disease progression on other hormonal treatments. This medicine is taken by mouth and is part of a broader treatment plan directed by your prescriber.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

To learn more about targeted therapy, see our overview Ibrance Palbociclib Targeted Treatment For Breast Cancer. You can also explore the condition hub for Breast Cancer.

Who It’s For

This treatment is indicated for adults with HR+ HER2‑negative metastatic or recurrent breast cancer. It is used:

• With an aromatase inhibitor as initial endocrine therapy
• With fulvestrant after progression on endocrine therapy

Premenopausal women and men may require ovarian suppression or appropriate endocrine partner therapy. People with uncontrolled infections, severe neutropenia, or known hypersensitivity to ingredients should avoid it. Your healthcare professional will review your history, lab results, and any prior therapies to decide if this option fits your plan. See more on Hormone Receptor Positive Breast Cancer and HER2‑Negative Breast Cancer.

Dosage and Usage

The typical starting schedule is one capsule daily for 21 days, followed by 7 days off, to complete a 28‑day cycle. Many adults start at 125 mg. Dosing can be modified by your prescriber based on blood counts and tolerability.

Take each dose with food and at the same time each day. Swallow capsules whole; do not open, crush, or chew. Avoid grapefruit products because they can change exposure to the medicine. Your care team will order regular complete blood counts before and during therapy, especially early in treatment.

If you take other anticancer therapies or supportive medicines, follow the sequence your clinician recommends. Do not change your dose without medical guidance; always consult the official label and your prescriber.

Strengths and Forms

Available as Pfizer Ibrance capsules in commonly published strengths:

• 125 mg
• 100 mg
• 75 mg

Presentations and pack sizes may vary by partner pharmacy and country. Your prescription will specify the appropriate strength for your regimen.

Missed Dose and Timing

If you miss a dose, take the next dose at the usual time. Do not take two doses at once to make up for a missed capsule. If you vomit after taking a dose, do not take an extra dose; resume with your next scheduled dose. Set phone reminders or use a pill organizer to help you stay on schedule.

Storage and Travel Basics

Store the capsules at room temperature in a dry place, away from excess heat and moisture, and out of reach of children and pets. Keep them in the original container with the label intact. When traveling, carry the medicine in your hand luggage with a copy of your prescription and a medication list. Security officers may ask to see labeled containers.

Some medicines require special handling. We maintain temperature-controlled handling when required and follow pharmacist guidance for safe fulfilment. Dispose of unused or expired capsules through local take‑back programs when available.

Benefits

This therapy targets CDK4/6 to help slow cell division in HR+ HER2‑negative disease. It is taken by mouth and pairs with endocrine therapy, which can be convenient for many adults. Regular lab monitoring allows clinicians to track blood counts and adjust treatment as needed. The approach can reduce the need for immediate intravenous chemotherapy in some treatment plans, depending on clinical factors.

Side Effects and Safety

• Low white blood cells (neutropenia)
• Infections, including upper respiratory tract infections
• Tiredness and weakness
• Nausea or vomiting
• Diarrhea or constipation
• Stomatitis or mouth sores
• Decreased appetite
• Hair thinning

Serious risks can include severe neutropenia and infections, interstitial lung disease or pneumonitis, and rare blood clots. Liver test changes can occur. This medicine can harm an unborn baby. Effective contraception is recommended during treatment and for a time after the last dose, as directed by official labeling. Do not breastfeed during treatment and for an advised period after the final dose. Seek urgent care for fever, breathing problems, chest pain, or signs of severe infection.

Drug Interactions and Cautions

Palbociclib is affected by CYP3A. Avoid strong CYP3A inhibitors (such as clarithromycin, ketoconazole, itraconazole) and strong CYP3A inducers (such as rifampin, carbamazepine, phenytoin). If a necessary interacting medicine is prescribed, your clinician may adjust your plan based on the label.

Avoid grapefruit or grapefruit juice. Tell your prescriber and pharmacist about all prescription drugs, over‑the‑counter products, herbal supplements, and vitamins you use, including St John’s wort. People with significant hepatic impairment or those prone to severe infections may need special caution and closer monitoring.

What to Expect Over Time

Treatment is given in 28‑day cycles. Blood counts are typically checked before starting, then regularly during the first cycles. Neutropenia is common and often occurs early; your care team will guide dose interruptions or adjustments when appropriate. Tumor response is assessed over time with exams, labs, and imaging, alongside symptom tracking.

Adherence matters. Take doses on schedule, keep appointments, and report side effects promptly. Your clinician can offer supportive care for nausea, diarrhea, or mouth soreness. If you are also on bone health therapies or ovarian suppression, your team will coordinate the overall plan.

Compare With Alternatives

CDK4/6 inhibitors are a core option for HR+ HER2‑negative metastatic disease. Alternatives include abemaciclib and ribociclib, used with endocrine partners based on clinical judgment. We offer Verzenio, which is another CDK4/6 inhibitor with its own dosing and safety profile. In some cases, chemotherapy may be chosen; for example, Doxorubicin can be part of certain regimens when appropriate. Decisions depend on disease features, prior therapies, and tolerability. References to Ibrance capsules here are for context; always follow your prescriber’s advice.

Pricing and Access

Canadian pharmacy partners offer competitive options, and fulfilment Ships from Canada to US for eligible prescriptions. The Palbociclib price can vary by strength and pack size and may differ from local cash‑pay amounts. See our current options, then add your prescription details to view availability. For possible seasonal offers, visit our Promotions page.

We use encrypted checkout for a secure experience. If you are comparing therapies for Advanced Breast Cancer, our team can help you understand required documents so your order moves smoothly.

Availability and Substitutions

Supply can vary. If your requested strength is not available, your prescriber may recommend an alternative plan that fits your regimen. There is currently no approved Ibrance generic in several markets; palbociclib availability differs by region and brand policy. Your pharmacy will dispense the exact product written on your prescription unless your prescriber authorizes a change.

Patient Suitability and Cost-Saving Tips

Good candidates typically have HR+ HER2‑negative metastatic or recurrent disease and can adhere to lab monitoring. People with a history of severe neutropenia or recurrent infections will require close oversight. Those who are pregnant or planning pregnancy should not use this medicine.

• Multi‑month supply: If appropriate, ask your prescriber about longer fills to reduce per‑order costs.
• Refill reminders: Set calendar alerts to prevent gaps between cycles.
• Coordination: Keep your clinician, oncology nurse, and pharmacist updated on side effects for timely support.
• Budget planning: Many patients research Ibrance cost per month to anticipate expenses; bring your questions to your care team.
• Documentation: Provide a clear prescription, clinician contact details, and known allergies to avoid order delays.

Speak with your prescriber about workplace schedules, childcare, and travel plans so your dosing cycles align with your routine. If you are switching endocrine partners, verify the start date for each medicine to keep the plan consistent.

Questions to Ask Your Clinician

• What lab tests and how often will I need them in the first cycles?
• How will side effects be managed if blood counts drop or symptoms worsen?
• Which endocrine partner is right for me now, and why?
• Are there medicines, foods, or supplements I should avoid while taking this treatment?
• What signs of infection should prompt a same‑day call?
• Can we review the Palbociclib capsules price considerations by strength and quantity?

Authoritative Sources

• Pfizer Ibrance (Manufacturer)
• FDA Prescribing Information
• Health Canada Drug Product Database

Ready to proceed? Place your order today for prompt, express shipping with US shipping from Canada. This content is for general information and does not replace medical advice from your healthcare professional.