Estradot® Transdermal Patch for Menopausal Symptoms

What Estradot Is and How It Works

Estradot® (Vivelle Dot) is a prescription estradiol transdermal system. It delivers estrogen through the skin to help manage menopausal symptoms. This page explains what it treats, how to use it, and how to access US shipping from Canada, including ways to compare costs without insurance.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine provides steady estradiol levels between patch changes. It supports relief of hot flashes, night sweats, and vaginal symptoms when included in a clinician-directed plan. The treatment bypasses first‑pass liver metabolism, which may reduce certain hormone swings compared with oral estrogen.

Who It’s For

This therapy is indicated for moderate to severe vasomotor symptoms due to menopause. It may also be used for moderate to severe symptoms of vulvar and vaginal atrophy and for prevention of postmenopausal osteoporosis when appropriate. People with a uterus often need a progestin to lower the risk of endometrial hyperplasia; your prescriber will advise.

Do not use if you have undiagnosed vaginal bleeding, known or suspected breast cancer or other estrogen‑dependent neoplasia, active or past blood clots, stroke, heart attack, severe liver disease, or if pregnant. Discuss migraine with aura, high blood pressure, high triglycerides, gallbladder disease, or a history of endometriosis with your healthcare professional.

Dosage and Usage

Follow the official label and your prescriber’s directions. Many patients apply one patch twice weekly, changing it every three to four days on a set schedule, such as Monday and Thursday. Your clinician may adjust the strength based on symptom control and tolerability, using the lowest effective dose for the shortest time consistent with goals.

Apply to clean, dry, hairless skin of the lower abdomen or buttocks. Avoid the breasts and waistline where clothing may rub. Press firmly for about 10 seconds to ensure good contact, especially around the edges. Rotate sites with each change to reduce skin irritation, leaving at least one week before using the same spot again. Do not cut the patch. If a patch loosens, try pressing it back; if it falls off, put on a new one and continue your regular schedule.

Strengths and Forms

This transdermal system is available in multiple strengths and sizes. Patches are designed to deliver estradiol over 24 hours and are typically changed twice weekly. Common presentations include:

• 25 mcg per 24 hours
• 37.5 mcg per 24 hours
• 50 mcg per 24 hours
• 75 mcg per 24 hours
• 100 mcg per 24 hours

Availability can vary by market. Your prescription determines which strength and quantity you receive.

Missed Dose and Timing

If you forget a change, apply a new patch as soon as you remember. Then return to your usual change days. Do not apply multiple patches to “make up” for a missed change. If a patch falls off early, replace it and keep your schedule. Consistent timing helps maintain steady symptom control.

Storage and Travel Basics

Store patches at room temperature in the original sealed pouches until use. Keep them away from direct sunlight, heat sources, and moisture. Do not refrigerate or freeze. Keep out of reach of children and pets.

When traveling, carry patches in your hand luggage along with a copy of your prescription. Keep them in their pouches until application. If crossing borders, have documentation ready to explain your medicine. Disposal: after removal, fold the adhesive sides together and discard safely per local guidance. Do not flush. Our partners use temperature-controlled handling when required.

Benefits

This estrogen therapy may reduce hot flashes and night sweats, and can help improve sleep disrupted by vasomotor symptoms. It can also support relief of vaginal dryness when part of an overall plan. Transdermal delivery offers convenient twice‑weekly application and avoids a daily pill routine. Many appreciate the steady hormone levels between changes.

Side Effects and Safety

• Application site irritation
• Headache or dizziness
• Breast tenderness
• Nausea or bloating
• Abdominal pain or cramps
• Mood changes

Serious risks can include blood clots, stroke, heart attack, gallbladder disease, and certain cancers. Estrogen alone increases the risk of endometrial hyperplasia and cancer in people with a uterus; a progestin may be recommended. Report leg pain or swelling, chest pain, shortness of breath, severe headache, vision changes, or jaundice immediately. Review your personal and family history with your prescriber before starting.

Drug Interactions and Cautions

Some medicines can affect estradiol levels. Strong CYP3A4 inducers (such as carbamazepine, phenytoin, rifampin) may reduce exposure, while inhibitors (such as ketoconazole, erythromycin, grapefruit) may increase it. Estrogen can alter thyroid hormone binding proteins; people on thyroid replacement may need monitoring. Estrogen can reduce lamotrigine levels. Discuss anticoagulants, corticosteroids, HIV therapies, and herbal products such as St. John’s wort with your clinician.

What to Expect Over Time

Many people notice gradual symptom changes after consistent use. Your clinician will reassess benefits and risks over time and may adjust the dose or duration. Continue routine checkups, including breast and pelvic exams as recommended. If symptoms return or side effects appear, contact your prescriber. Do not stop or change your schedule without medical guidance.

Compare With Alternatives

Some patients use a local vaginal estrogen for genitourinary symptoms while continuing a systemic patch for hot flashes. A vaginal insert option is Imvexxy. Nonhormonal agents may be considered for those who cannot use estrogen; your clinician can advise based on your history and goals. Therapy choice depends on symptom pattern, risk factors, and preferences.

Pricing and Access

We display transparent options so you can compare choices and work with your prescriber. If you are checking Estradot patch price, review your strength and supply with your clinician so the listing matches your prescription. People comparing Vivelle Dot price often look at the same strengths and schedules to keep estimates consistent.

Your order benefits from Canadian marketplace efficiencies with Ships from Canada to US, while your prescription and safety checks stay central. To explore additional savings, see our Promotions page for current offers when available.

Availability and Substitutions

Supply can vary by strength and pack size. If a specific patch is unavailable, your prescriber may recommend a therapeutically appropriate alternative or a different strength with adjusted scheduling. Ask about Estradot Canadian pricing when considering comparable options approved by your clinician. Pharmacy teams dispense only according to your prescription and local regulations.

Patient Suitability and Cost-Saving Tips

This treatment may suit people with moderate to severe vasomotor symptoms who can use estrogen safely. It may not suit those with a history of blood clots, stroke, certain cancers, or severe liver disease. If you and your prescriber decide to proceed, consider multi‑month supplies to reduce per‑fill fees and help maintain continuity. Enable refill reminders so you do not miss scheduled changes. Some patients compare Pay cash estradiol patch options against insurer deductibles to decide which path is most efficient.

Explore related categories for broader options in Hormone Replacement Therapy, overall Womens Health, focused Menopause, and symptom guidance under Menopausal Symptoms. Product origin details are shown under Canada.

Questions to Ask Your Clinician

• My main symptoms and goals
• Starting dose and schedule
• Need for a progestin
• Monitoring and follow‑up
• Personal clot and cancer risks
• Nonhormonal options
• Plan for tapering or stopping

Authoritative Sources

For full details, review official labeling and databases:

• FDA DailyMed
• Health Canada Drug Product Database
• FDA Orange Book

Ready to move forward? You can place your request with prompt, express shipping and US shipping from Canada. This information is not a substitute for medical advice; always follow your prescriber and the official label.