Adcirca (tadalafil) tablets

Adcirca is a prescription medicine containing tadalafil for pulmonary arterial hypertension (PAH). It is used as long-term therapy to help improve exercise ability in this condition. This page explains how it works, what to know about dosing and safety, and how access typically works on BorderFreeHealth, including Ships from Canada to US for people paying cash without insurance.

What Adcirca Is and How It Works

Adcirca is a phosphodiesterase type 5 inhibitor (PDE5 inhibitor), a class that helps blood vessels relax. In PAH, the pressure in the lung arteries is higher than normal, which can strain the right side of the heart. By supporting vasodilation (blood-vessel widening) in the pulmonary vasculature, tadalafil can lower resistance in those vessels and help people tolerate activity better over time.

Prescriptions are verified with prescribers before dispensing. This treatment is not designed for sudden symptom relief. It is taken on a steady schedule so the medicine level stays consistent. While tadalafil is also used in other settings, PAH dosing and monitoring are different, so it helps to keep the indication clear in records and refill requests.

Who It’s For

This medicine is generally prescribed for adults diagnosed with pulmonary arterial hypertension (Group 1 PAH) by a qualified clinician, often after testing such as echocardiography and sometimes right-heart catheterization. It may be considered when a prescriber is aiming to improve functional capacity and reduce symptom burden such as shortness of breath on exertion. For broader context on the condition and related therapies, browse the Pulmonary Hypertension hub.

It is not appropriate for everyone. Key situations where tadalafil products may be unsafe include use with nitrate medicines (often used for chest pain) and use with riociguat, because severe low blood pressure can occur. Clinicians also weigh risks in people with significant heart disease, recent cardiovascular events, serious liver problems, or advanced kidney disease. Vision conditions such as retinitis pigmentosa and prior non-arteritic ischemic optic neuropathy (NAION) are also important to disclose before therapy is prescribed.

Dosage and Usage

For PAH, tadalafil is typically taken once daily at the same time each day, with or without food. The labeled PAH regimen commonly targets a total daily dose of 40 mg, but the exact plan can vary based on kidney or liver function and other medicines. Adcirca is taken as directed by the prescriber and should not be combined with other PDE5 inhibitors unless the clinician explicitly directs it.

When a dose is missed, general label-style guidance is to take it when remembered if it is still the same day, then return to the regular schedule. If it is close to the next dose, the missed dose is usually skipped rather than doubled. For background on related therapies used in PAH care, see Sildenafil For Pulmonary Hypertension. For information on blood-pressure effects that may be relevant to monitoring, review Cialis Lower Blood Pressure.

Strengths and Forms

Adcirca is supplied as an oral tablet. It is commonly available as a 20 mg tablet, and the 40 mg daily PAH regimen may be provided as two 20 mg tablets taken together, depending on how the prescription is written. Tablets are swallowed and are not meant to be split or crushed unless a pharmacist provides product-specific guidance for a documented need.

Medication is dispensed by licensed Canadian partner pharmacies. Some pharmacies may also offer generic tadalafil labeled for PAH, and availability can change with supply. It is important not to assume that low-dose tadalafil products used for other indications (such as 5 mg daily regimens) are interchangeable with PAH therapy without a prescriber’s review. For related medication categories commonly discussed in cardiopulmonary care, browse the Cardiovascular Category listings.

Storage and Travel Basics

Store tablets at controlled room temperature and keep them protected from excess moisture and heat. Many products recommend keeping the medication in its original container with the label intact, which also helps with safe use and refill processing. Do not use tablets past the labeled expiration date, and keep all prescription medicines out of reach of children and pets.

Quick tip: Keep a current medication list in the same place as travel documents.

For travel, carrying the medicine in a hand bag can help avoid temperature extremes in checked luggage. If crossing time zones, patients commonly ask their clinician how to keep once-daily timing consistent without taking doses too close together. For more heart-health education and practical reminders that may be useful alongside PAH treatment planning, explore Cardiovascular Posts.

Side Effects and Safety

Like other PDE5 inhibitors, tadalafil can cause side effects related to blood-vessel relaxation and smooth-muscle effects. Commonly reported effects include headache, flushing, nasal congestion, indigestion, back pain, muscle aches, and pain in the arms or legs. These effects are often mild to moderate, but they should be discussed with a healthcare professional if persistent, bothersome, or worsening.

Serious reactions are uncommon but require urgent attention. With Adcirca, seek emergency help for chest pain, fainting, or severe dizziness; an erection lasting longer than 4 hours (priapism); sudden vision loss; sudden hearing decrease or ringing; or signs of an allergic reaction such as swelling of the face, lips, or throat. Because the drug can lower blood pressure, clinicians may monitor symptoms more closely when therapy starts or when other vasodilators are added. For a deeper discussion of longer-term tolerability topics, see Tadalafil Side Effects Long Term.

Drug Interactions and Cautions

Important interactions are well described for tadalafil products. Nitrates (including nitroglycerin) and riociguat are the highest-risk combinations due to potentially dangerous hypotension. Other blood-pressure-lowering medicines, alpha-blockers, and significant alcohol intake can also increase the chance of lightheadedness. Grapefruit products may affect drug levels in some people, depending on overall diet and metabolism.

Why it matters: Interaction-driven blood pressure drops can be dangerous in PAH.

Drug metabolism interactions are also relevant. Strong CYP3A inhibitors (for example, certain azole antifungals or HIV protease inhibitors) can raise tadalafil exposure, while strong CYP3A inducers can lower it, which may affect how the therapy performs. People comparing PDE5 inhibitors across conditions sometimes find it helpful to read Sildenafil Vs Tadalafil and Cialis Vs Viagra, then confirm PAH-specific implications with their prescriber.

Compare With Alternatives

In PAH treatment plans, clinicians may consider other medication classes based on risk profile, symptoms, and testing results. Alternatives or add-on options can include sildenafil (another PDE5 inhibitor), endothelin receptor antagonists, prostacyclin pathway therapies, or soluble guanylate cyclase stimulators. Adcirca is one PDE5 inhibitor option used in PAH, and selection is individualized using guideline frameworks and clinical response rather than a one-size schedule.

Some people with PAH may also be prescribed supportive medicines for related issues such as fluid retention or clot-risk management, depending on the underlying cause and clinician judgment. Examples of related prescriptions listed on the site include Furosemide Injection and Warfarin Medication, though these are not direct substitutes for PAH-targeted vasodilator therapy. Any combination plan should be reviewed for interaction and monitoring needs.

Pricing and Access

Out-of-pocket pricing for tadalafil-based PAH therapy can vary by strength, quantity, and whether a brand or generic is selected. Many patients explore cash-pay pathways when coverage is limited, and a prescription is still required. BorderFreeHealth supports cross-border fulfillment models, including US delivery from Canada, while keeping the process focused on appropriate documentation.

Cash-pay access can help when paying without insurance is the practical option. Adcirca requests are routed through partner pharmacies, and the prescription details are confirmed with the prescriber as part of the dispensing workflow. To avoid delays, it helps to ensure the prescription matches the intended PAH regimen, includes refills when appropriate, and lists any recent medication changes that could affect interaction screening.

Authoritative Sources

The most reliable dosing, contraindication, and interaction details come from official labeling and established medical references. These sources can also help clinicians and patients align expectations about what the medicine can and cannot do in PAH, and what symptoms should trigger urgent evaluation.

For U.S. prescribing information, review the FDA drug labeling database and locate tadalafil labeling for PAH products.

For patient-friendly safety and interaction information, see MedlinePlus tadalafil information, including warning signs and common side effects.

When placing a site order, select prompt, express shipping if it fits the needed timeframe.

This content is for informational purposes only and is not a substitute for professional medical advice.