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wellbutrin and trazodone combination side effects

Can You Take Wellbutrin and Trazodone Together? Safety Explained

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If you’re dealing with depression, anxiety, or trouble sleeping, you might have heard about Wellbutrin and Trazodone. Because they’re both effective, combining them is something many people explore. But is this possible and safe? Can you take Wellbutrin and Trazodone together? Let’s find out here! 

What Are Wellbutrin and Trazodone?

Wellbutrin (also known as bupropion) is an antidepressant that mainly affects dopamine and norepinephrine in the brain. It is commonly used to treat major depressive disorder and seasonal affective disorder (SAD). 

Trazodone, on the other hand, is another antidepressant, but it works by increasing serotonin levels. It is often prescribed for depression, anxiety, and especially sleep problems due to its calming and sedative effects. 

When thinking about Wellbutrin and Trazodone combination side effects, note that the reactions can still happen and should be discussed with a doctor. However, many people like Wellbutrin because it usually has fewer side reactions than other antidepressants, like weight gain or sexual problems. 

What Happens When You Take Them Together?

Since these medications affect different brain chemicals, doctors may sometimes prescribe them together to treat symptoms in different ways. However, it’s important to be aware of possible Trazodone and Wellbutrin interactions and their risks.

Serotonin Syndrome: This is a rare but serious problem that happens when there’s too much serotonin in the brain. It can cause confusion, restlessness, or a fast heartbeat. 

Feeling Very Sleepy: Both medications can make you feel tired, especially Trazodone. Taking them together might make you extra drowsy, so be careful with activities like driving or using machines.

Seizure Risk: Wellbutrin can increase the chance of seizures, especially at higher doses. Trazodone doesn’t usually cause seizures, but taking both might slightly raise the risk, especially if you’ve had seizures before.

Can You Take Wellbutrin in the Morning and Trazodone at Night?

Yes, this is a common schedule. Wellbutrin can be stimulating, so it’s usually taken in the morning to help boost daytime energy and reduce the chance of insomnia. Trazodone, with its sedating effect, is often taken at night to help with sleep. 

As always, your doctor will recommend the best timing and dosage based on your individual needs and health background. 

Why Take Wellbutrin in the Morning?

Because Wellbutrin can increase energy and alertness, taking it in the morning helps you feel more focused and productive during the day. Taking it too late might make it harder to fall asleep at night. 

What About Using Wellbutrin and Trazodone for Sleep?

Wellbutrin isn’t typically used to treat sleep issues, it may even make insomnia worse for some people. But Trazodone is often used off-label as a sleep aid, especially when depression and anxiety are also present. 

Your doctor may suggest this combination if you need daytime support from Wellbutrin and help sleeping at night from Trazodone. 

Bottom Line

So, can you take Wellbutrin and Trazodone together? Wellbutrin and Trazodone are both useful for treating depression and related issues, and in some cases, they can be safely used together. However, this should only be done under a doctor’s supervision, since combining them can carry risks like increased drowsiness or, rarely, serotonin syndrome or seizures.

If you’re thinking about starting or combining these medications, talk openly with your healthcare provider. They’ll help you weigh the benefits and risks and find a treatment plan that works best for you.

Frequently Asked Questions (FAQs)

Can you take Trazodone and Wellbutrin and at the same time of day?

It’s usually not recommended. It’s best to take Wellbutrin in the morning because it can give you energy. Trazodone is usually taken at night since it helps you sleep.

What should I do if I feel weird after taking both medications?

If you feel overly drowsy, anxious, or notice anything unusual, like a fast heartbeat or confusion, contact your doctor right away. These could be signs of side effects or interactions that need medical attention.

Can I take Wellbutrin and Trazodone together?

Yes, but only under medical supervision. While some people may benefit from taking both, combining them can increase the risk of side effects like drowsiness or, in rare cases, serotonin syndrome.  

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Written by BFH Staff Writer on February 16, 2024

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