Vimovo® Tablets for Arthritis Pain

Vimovo® is a prescription tablet that combines naproxen and esomeprazole for arthritis pain. This page explains uses, safety, and how to order with US delivery from Canada, including options without insurance.

What Vimovo Is and How It Works

This medicine pairs an NSAID (naproxen) with a proton pump inhibitor (esomeprazole). The NSAID helps reduce pain and inflammation in arthritis. The PPI lowers stomach acid to help reduce the risk of NSAID-associated gastric ulcers in at-risk adults. Some prescriptions are written for naproxen esomeprazole 500mg 20mg, based on your clinician’s judgment.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

It works through two pathways. Naproxen limits inflammatory prostaglandins, easing joint pain and stiffness. Esomeprazole blocks acid pumps in the stomach lining, which can help protect the upper GI tract while you take an NSAID.

Who It’s For

This therapy is intended for adults who need NSAID treatment for osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, and who may benefit from added GI protection. People with a history of aspirin-sensitive asthma, severe allergic reactions to NSAIDs or PPIs, active GI bleeding, or recent coronary artery bypass graft surgery should avoid this product. It may not be appropriate during pregnancy, especially later in pregnancy, or with severe kidney problems. Discuss your medical history with a healthcare professional before starting.

Learn more about these conditions: Osteoarthritis, Rheumatoid Arthritis, and Ankylosing Spondylitis. For related options, see our Pain Inflammation category and item origin details under Canada.

Dosage and Usage

Typical adult directions call for one tablet taken twice daily, at least 30 minutes before meals, in the morning and evening. A prescription may specify Vimovo 500 20mg when clinically appropriate. Swallow tablets whole with a glass of water; do not split, chew, or crush. Use the lowest effective dose for the shortest duration consistent with individual treatment goals. Do not combine with other naproxen or NSAIDs unless your prescriber has advised this approach.

Check the official label for full instructions. If you have swallowing difficulties, ask your clinician for guidance rather than altering the tablet.

Strengths and Forms

This treatment is supplied as delayed-release tablets. Commonly available strengths include:

• Vimovo 375 20 mg tablets
• Naproxen/esomeprazole 500/20 mg delayed-release tablets

Availability can vary by pharmacy and market. Your prescription will specify the appropriate strength and quantity.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is near the time of your next dose. Skip the missed dose if it is almost time for the next one and resume your regular schedule. Do not double up. This holds whether you are prescribed naproxen and esomeprazole 500 20 mg tablets or another strength. Taking doses consistently before meals may help maintain predictable GI protection.

Storage and Travel Basics

Store tablets at room temperature in the original container with the lid tightly closed. Protect from moisture and keep out of reach of children and pets. Do not store in a hot car or humid bathroom. When traveling, carry your medicine in your hand luggage with the prescription label visible. Keep a simple schedule by aligning morning and evening doses with local time when you arrive. Our pharmacy partners use temperature-controlled handling when required to maintain quality during transit.

Benefits

Combining an NSAID with a PPI in one tablet can simplify your regimen. The therapy may help manage arthritis pain while reducing the risk of NSAID-associated gastric ulcers in certain patients. Taking one co-formulated tablet instead of two separate medicines can support adherence. Morning and evening dosing also fits many daily routines.

Side Effects and Safety

• Common effects: heartburn, nausea, diarrhea, constipation, gas
• Headache or dizziness
• Abdominal discomfort or indigestion
• Upper respiratory symptoms

Serious risks can occur, though they are less common. NSAIDs may increase the risk of heart attack and stroke and can cause GI bleeding or ulcers, which may occur without warning. Kidney problems, liver injury, severe skin reactions, and allergic responses can also happen. PPIs may be associated with Clostridioides difficile diarrhea, low magnesium, and, with long-term high-dose use, possible bone fracture risk. Get urgent care for chest pain, trouble breathing, black stools, vomiting blood, severe rash, or swelling of the face or throat.

If you use insulin or a sulfonylurea for diabetes, watch for low blood sugar symptoms when pain improves and activity changes; seek clinician guidance as needed.

Drug Interactions and Cautions

Tell your prescriber about all medicines, vitamins, and herbal products you take. Important interactions include:

• Anticoagulants and antiplatelets: higher bleeding risk
• SSRIs/SNRIs: additive GI bleeding risk
• Other NSAIDs or aspirin: increased GI and renal risks
• ACE inhibitors, ARBs, or diuretics: potential kidney effects
• Lithium, methotrexate, or digoxin: levels may rise
• Clopidogrel: PPI component may reduce antiplatelet activation
• Antifungals and HIV medicines: altered PPI metabolism
• Tacrolimus: PPI may increase levels

Avoid use late in pregnancy unless advised by your clinician due to potential fetal risks with NSAIDs. Do not use after a recent CABG surgery. People with a history of GI bleeding or peptic ulcer disease should discuss additional precautions. Alcohol can worsen stomach irritation; moderation is prudent.

What to Expect Over Time

Pain relief may begin after doses are underway, but individual responses vary. Consistent morning and evening dosing supports steady anti-inflammatory effects and continuous acid suppression. Your prescriber may reassess your symptoms and tolerability over time. Keep track of how you feel, any side effects, and any changes in other medicines. If benefits or tolerability are not where you need them, talk with your clinician about adjustments or alternatives.

Compare With Alternatives

Some patients do well with an NSAID alone, such as Naproxen, plus a separate PPI if needed. Others may use a COX-2 selective NSAID option, depending on clinical judgment and risk factors. In cases where separate components are preferred, a prescriber might consider pairing an NSAID with Esomeprazole to individualize dosing.

For educational reading on related choices, see Celebrex And Arthritis, Celebrex Vs Ibuprofen, and Celebrex Vs Meloxicam.

Pricing and Access

We list current options so you can review the Vimovo price without insurance and compare quantities before checkout. Listings reflect Canadian pharmacy supply, and orders are fulfilled by licensed partners. Delivery to the United States Ships from Canada to US. For deals and helpful notices, check our Promotions page.

Savings tip: ask your prescriber if a multi-month fill is appropriate. Pricing can vary by strength and pack size; see the product page for live availability. If you need a copy of your receipt for reimbursement, you can download it from your account.

Availability and Substitutions

Stock can vary. If a particular strength or pack size is unavailable, a prescriber may recommend an alternative strength, a different NSAID, or separate components. Some markets offer a Generic for Vimovo; your clinician will decide if that option meets your needs. We do not post restock dates, but you can check the page for updates.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults who need ongoing NSAID treatment and have GI risk factors such as prior ulcers, age, or concurrent anticoagulants. It may not be suitable if you have uncontrolled heart disease, significant kidney impairment, or a history of severe NSAID or PPI reactions.

Cost-saving ideas include asking for the lowest effective strength that meets your goals, discussing separate components if appropriate, and considering longer fills to reduce per-shipment fees. Set refill reminders in your phone, and keep a small buffer so you do not run out while traveling.

Questions to Ask Your Clinician

• Right candidate: how do my GI and heart risks affect NSAID choice?
• Dose and schedule: what strength and timing fit my routine?
• Monitoring: which labs or check-ins do I need while on therapy?
• Interactions: do my current medicines raise bleeding or kidney risks?
• Pregnancy and lactation: what are safer options if planning a pregnancy?
• Duration: how long should I stay on this treatment before reassessment?

Authoritative Sources

FDA DailyMedHealth Canada Drug Product DatabaseManufacturer Information

Ready to proceed? You can Buy Vimovo online with prompt, express shipping and US shipping from Canada. This information is educational and not a substitute for advice from your healthcare professional.