Abilify Maintena

Abilify Maintena is a long-acting injectable form of aripiprazole, an atypical antipsychotic used to treat schizophrenia and maintenance treatment of bipolar I disorder in adults. It works by balancing dopamine and serotonin activity in the brain, helping to manage symptoms and prevent relapse. It is administered monthly by a healthcare professional.

Benefits

• Provides consistent medication levels for up to one month
• Helps manage symptoms of schizophrenia and bipolar I disorder
• Reduces the risk of relapse in long-term treatment
• Improves treatment adherence by eliminating the need for daily dosing
• May enhance quality of life and stability for patients requiring maintenance therapy

Dosage

• Schizophrenia and Bipolar I Disorder (maintenance):
  Recommended dose: 400 mg once monthly via intramuscular injection
  Dose may be reduced to 300 mg monthly if needed due to adverse effects
  Oral aripiprazole should be continued for 14 days after the first injection to maintain therapeutic levels
  Injection should be given in the gluteal or deltoid muscle by a healthcare professional

Warnings and Precautions

• May increase risk of suicidal thoughts, especially in young adults
• Can cause tardive dyskinesia—uncontrolled body or facial movements
• Risk of neuroleptic malignant syndrome, a rare but serious condition
• May cause weight gain, high blood sugar, and increased cholesterol
• Not approved for treatment of dementia-related psychosis in elderly patients
• Use with caution in patients with cardiovascular disease, seizures, or a history of stroke

Usage Instructions

• Administered once monthly by a healthcare professional
• Should not be self-administered
• Oral supplementation with aripiprazole is required for the first 14 days after initial injection
• Attend all scheduled appointments for timely administration
• Do not discontinue treatment without medical advice

Storage Information

• Store in the refrigerator between 2°C and 8°C (36°F and 46°F)
• May be stored at room temperature up to 25°C (77°F) for up to 24 hours before use
• Protect from light and do not freeze
• Keep out of reach of children

Common Side Effects

• Weight gain
• Injection site pain or swelling
• Akathisia (restlessness)
• Anxiety or insomnia
• Headache
• Nausea
• More serious side effects may include seizures, high blood sugar, or movement disorders