Bosulif® Tablets for Chronic Myeloid Leukemia

Bosutinib is a prescription tyrosine kinase inhibitor used to treat adults with Philadelphia chromosome–positive chronic myeloid leukemia. This page explains how it works, who it may suit, and how you can access it with US delivery from Canada. We also outline what affects the Bosulif® price without insurance.

What Bosulif Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing. This medicine targets the BCR-ABL tyrosine kinase that drives Ph+ CML growth. It also inhibits SRC family kinases, which may contribute to activity in resistant disease. The treatment is taken by mouth and is intended for long-term management under a clinician’s supervision. Most patients take it once daily with food to support tolerability. As with other Chronic Myeloid Leukemia therapies, monitoring and dose adjustments may be required. Labeling aligns with use in newly diagnosed or previously treated Ph+ CML across select phases.

The class is supplied as bosutinib tablets, which work inside cancer cells to block abnormal signaling. Inhibition reduces proliferation of leukemic cells. Unlike chemotherapy, kinase inhibitors act on specific molecular targets. Your prescriber will confirm if this approach fits your diagnosis and treatment history.

Who It’s For

This therapy is indicated for adults with Philadelphia chromosome–positive CML. It may be used in chronic phase at diagnosis or after prior tyrosine kinase inhibitors when resistance or intolerance occurs. It is also approved for certain accelerated or blast phase cases, as directed by the official label. People with significant liver problems, severe drug interactions, or known hypersensitivity should avoid it. Those who are pregnant or planning to become pregnant should discuss risks and contraception with their prescriber.

For broader context on targeted options, see our article Bosulif Treats CML.

Dosage and Usage

Standard regimens are once daily with food and swallowed whole. Do not crush or split tablets. Initial dosing varies by disease phase and prior therapy. A common starting dose is bosutinib 400 mg for newly diagnosed chronic phase, with your prescriber adjusting based on response and tolerability per labeling. Some patients may require stepwise changes or temporary holds for side effects.

General tips:

• Take at the same time each day with a meal.
• Avoid grapefruit products due to interaction risk.
• Report persistent diarrhea, nausea, or fatigue promptly.
• Have regular labs to monitor blood counts, liver function, and kidney function.

If uncertainty arises, defer to the official prescribing information or your healthcare professional’s instructions.

Strengths and Forms

Available as film-coated oral tablets. Common strengths include 100 mg, 400 mg, and 500 mg. Color and imprint vary by strength. Packaging and availability may differ by manufacturer lot and market. Your dispensed strength will match your prescription. If your dose changes, your prescriber may alter the tablet strength or schedule.

Missed Dose and Timing

If you miss a dose, take the next dose at the regular time. Do not double up to make up a missed tablet. If vomiting occurs after a dose, do not take an extra tablet that day. Consistent daily timing helps maintain steady levels. Use a medication reminder or calendar to support adherence.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from excess heat and moisture. Keep the bottle closed tightly and out of reach of children and pets. Do not store in a bathroom. For travel, carry the original labeled container in your carry-on, along with a copy of the prescription or pharmacy receipt. Time-zone changes do not require exact 24-hour spacing to the minute; take the tablet at the usual local time with food. If your itinerary is complex, ask your prescriber for a simple plan before you depart.

Benefits

This targeted therapy offers once-daily oral dosing and a mechanism directed at BCR-ABL. It can be used when resistance or intolerance to another TKI occurs, per labeling. The tablets allow at-home use rather than infusion center visits. Ongoing monitoring helps prescribers personalize dose and manage side effects over time.

Side Effects and Safety

Common effects can include:

• Diarrhea or loose stools
• Nausea or vomiting
• Abdominal discomfort
• Rash or itching
• Fatigue or headache
• Elevated liver enzymes on lab tests

Serious risks include liver toxicity, severe diarrhea, fluid retention, myelosuppression, and kidney effects. Rare events such as cardiac issues may occur. Your clinician may perform baseline and periodic blood tests to monitor safety. Seek urgent care for signs of severe allergic reaction, yellowing of the skin or eyes, uncontrolled diarrhea, chest pain, or unusual bleeding.

Drug Interactions and Cautions

Strong or moderate CYP3A inhibitors and inducers can change bosutinib levels; examples include certain antifungals, macrolide antibiotics, anticonvulsants, and rifamycins. Proton pump inhibitors can reduce absorption; prescribers may prefer alternatives. If using H2 blockers or antacids, spacing strategies may be recommended. Avoid grapefruit and grapefruit juice. Use caution with other hepatotoxic drugs. Tell your clinician about all medicines, vitamins, and herbals you take. See also our overview of TKI safety discussions in Tasigna Side Effects.

What to Expect Over Time

Response assessment usually relies on blood counts and molecular testing at set intervals. Your prescriber will review results, check side effects, and adjust dosing when appropriate. Some effects start early, such as gastrointestinal symptoms, and often improve with supportive care. Long-term goals include maintaining remission and managing tolerability. Adherence, hydration, and timely lab work support consistent outcomes.

Compare With Alternatives

Other approved TKIs for Ph+ CML include dasatinib and asciminib. If you and your clinician consider switching, two options we offer are Sprycel® and Scemblix®. Each has distinct dosing, food guidance, and interaction profiles. Selection depends on disease phase, prior therapies, mutation profile, comorbidities, and tolerability history. Your prescriber will tailor therapy to your clinical picture.

Pricing and Access

Canadian pharmacy sourcing can help reduce the Bosulif price compared with many local cash-pay rates. We show transparent options and provide a secure, encrypted checkout. You can review availability, submit your prescription, and confirm details with our team. We support US shipping from Canada to your address after verification. If you watch for seasonal offers, see our current Promotions. For additional context on oncology options and access, explore Cancer and our origin detail at Canada.

Availability and Substitutions

Supply can vary. If your prescribed strength or pack is not available, a prescriber may recommend an alternative medicine or a temporary change aligned with the label. We cannot promise restock dates. Your care team decides on any substitutions based on clinical need and safety.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with Ph+ CML who can adhere to daily oral dosing and complete regular monitoring. It may not be appropriate for those with significant hepatic impairment, uncontrolled diarrhea, or interacting drugs that cannot be modified. To manage costs, ask your prescriber about multi-month fills and synchronized refills. Setting reminders helps prevent gaps in therapy. If you change addresses or travel, confirm storage plans and refill timing in advance.

Questions to Ask Your Clinician

• Is this TKI appropriate for my CML phase and mutation profile?
• What baseline and follow-up labs will you order and how often?
• How should I manage diarrhea, nausea, or rash if they occur?
• Which medicines or supplements should I stop or space apart?
• What food or beverage restrictions apply to my regimen?
• How will you evaluate response and decide on adjustments?
• What is the plan if I miss doses during travel or illness?

Authoritative Sources

Ready when your prescriber is? Buy Bosulif online with prompt, express shipping and Ships from Canada to US. This content is for general information and does not replace your clinician’s advice.