Cresemba® Capsules for Aspergillosis and Mucormycosis

Cresemba® is a prescription antifungal for invasive aspergillosis and mucormycosis. This page explains how the treatment works, dosing basics, safety, and how to request US delivery from Canada, plus options for those paying without insurance.

What Cresemba Is and How It Works

Cresemba is the prodrug of isavuconazole, a triazole antifungal that inhibits fungal cell membrane synthesis. It’s used for invasive mold disease, including Aspergillosis and Mucormycosis in adults. The medicine disrupts ergosterol production, weakening the fungal cell membrane so growth slows or stops.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

The class has broad activity against Aspergillus species and Mucorales. It can be started intravenously, then continued orally when appropriate. Label information guides therapy selection and duration for each infection.

Common clinical references describe Isavuconazonium sulfate uses for invasive mucormycosis and aspergillosis when susceptible organisms are suspected or confirmed.

Who It’s For

This treatment is for adults diagnosed with invasive aspergillosis or mucormycosis, based on clinical, radiologic, and microbiology findings. It may be considered when first-line azoles are unsuitable, or when step-down from hospital therapy is appropriate.

People with familial short QT syndrome should avoid it. Serious liver disease, known hypersensitivity to azoles, or strong CYP3A4 drug interactions may also preclude use. The term Isavuconazonium appears in prescribing resources describing eligibility and cautions with this antifungal prodrug.

Dosage and Usage

Follow the approved label and your clinician’s instructions. Therapy usually begins with a loading phase, followed by once-daily maintenance. Oral capsules are swallowed whole and can be taken with or without food. Do not open, crush, or chew capsules.

Intravenous therapy is an option in hospital settings, then transition to oral capsules when stable. The therapy schedule and total duration depend on the site of infection, response, tolerability, and immune status. Labeling describes how Isavuconazonium sulfate is dosed for invasive mold infections.

Regular follow-up is important. Your healthcare professional may monitor liver enzymes and evaluate clinical response at intervals.

Strengths and Forms

Common presentations include:

• Capsules: 186 mg isavuconazonium sulfate per capsule (equivalent to 100 mg isavuconazole).
• Intravenous powder for solution: 372 mg vial, used in hospital settings under clinical supervision.

Availability may vary by country and by pharmacy. Some patients begin with IV treatment and later switch to capsules when appropriate.

Missed Dose and Timing

If you miss a capsule dose, take it when you remember unless it is close to your next scheduled dose. If it is almost time for the next dose, skip the missed dose. Do not take two doses at the same time. Try to take the capsule around the same time each day to support consistent levels.

Storage and Travel Basics

Store capsules at room temperature in their original container, away from excess moisture. Keep out of reach of children and pets. For travel, carry the medicine in your hand luggage with the prescription label, and bring a copy of your prescription or clinic letter if possible. Do not repack capsules into unmarked containers. If you are traveling across time zones, keep a simple schedule and set reminders to maintain daily dosing.

For IV therapy, hospitals manage storage and preparation. If your care involves step-down to capsules, your clinician will coordinate the transition.

Benefits

This therapy offers both IV and oral options, which can support continuity of care from hospital to home. Maintenance is taken once daily after the loading phase, which can aid adherence. The antifungal activity covers many invasive molds when organisms are susceptible, allowing a single agent to be used across different care settings.

Side Effects and Safety

• Digestive: nausea, vomiting, diarrhea, abdominal pain.
• Liver: increased enzymes, possible hepatitis signs.
• General: headache, fatigue, cough, shortness of breath.
• Laboratory: low potassium, edema, or other electrolyte changes.
• Infusion-related: during IV use, reactions may occur.

Serious risks are uncommon but can include severe liver injury, serious skin reactions, allergic reactions, or cardiac effects. This medicine can shorten the QT interval; avoid it with familial short QT syndrome. Seek medical help for jaundice, severe rash, trouble breathing, or chest symptoms. Hypoglycemia warnings do not apply directly, but anyone on complex regimens should review overall risks with a prescriber.

Drug Interactions and Cautions

Strong CYP3A4 inducers (for example, rifampin, carbamazepine, St. John’s wort) can lower levels and are typically contraindicated. Strong CYP3A4 inhibitors (such as high-dose ritonavir or ketoconazole) can raise levels and are generally avoided.

Use caution with immunosuppressants metabolized by CYP3A4 (tacrolimus, sirolimus, cyclosporine), certain benzodiazepines, digoxin, and warfarin. Monitor liver function during therapy. Avoid use in familial short QT syndrome, and review other drugs that may shorten QT. Discuss pregnancy and lactation planning with your clinician before starting therapy.

For broader context on care pathways, you can review our Infectious Disease category.

What to Expect Over Time

Response depends on the site and severity of infection and on immune status. Some symptoms may begin to ease as the infection is controlled, but treatment can continue for weeks or longer. Your prescriber may order lab tests and imaging at intervals. Staying on schedule, reporting side effects promptly, and attending follow-ups can help the plan stay on track.

If you begin with hospital therapy, a step-down to oral capsules may be planned. Keep a daily reminder to support adherence during maintenance phases.

Compare With Alternatives

Other antifungals for invasive mold disease include voriconazole and posaconazole for aspergillosis, and amphotericin B products for mucormycosis, depending on susceptibility and tolerance. Selection depends on infection type, prior therapy, interactions, and organ function. Your prescriber will choose and adjust therapy using official labeling and current guidelines.

Pricing and Access

We offer transparent options so you can review current pharmacy pricing and request fulfilment that Ships from Canada to US with a valid prescription. Many patients ask about the Cresemba price without insurance. We show available cash-pay options when listed by our Canadian partners.

You can also compare the Isavuconazonium sulfate price shown on our site with what you see locally, keeping in mind that costs vary by supplier and pack size. For potential deals, check our Promotions page. Checkout is protected with encrypted checkout for your security.

Availability and Substitutions

Supply may vary by strength and pack. If the requested item is unavailable, your prescriber may recommend an appropriate alternative based on the infection and your medical history. We also carry related treatments for infectious diseases, such as Cephalexin and Ceftin Suspension, when antibiotics are indicated for bacterial infections.

Patient Suitability and Cost-Saving Tips

Adults with confirmed or strongly suspected invasive aspergillosis or mucormycosis may be candidates. People with familial short QT syndrome or severe uncontrolled liver disease are generally not candidates. Those on complex regimens should review all medicines with a prescriber to avoid interactions.

Ask your clinician whether a multi-month supply makes sense for your course of therapy. Setting calendar reminders helps keep daily dosing consistent. If travel is planned, prepare refills early and carry documents in hand luggage. Patients sometimes compare Isavuconazonium cost across pharmacies; review Canadian listings and your local options to understand the range.

Questions to Ask Your Clinician

• Diagnosis details: which organism is suspected or confirmed?
• Therapy plan: how long might treatment continue if I respond?
• Monitoring: what labs or imaging will you order and how often?
• Interactions: which medicines or supplements should I stop or avoid?
• Safety: what warning signs mean I should contact the clinic?
• Transition: when could I switch from IV to capsules, if applicable?

Authoritative Sources

Astellas Cresemba Prescribing Information

DailyMed: Cresemba

Health Canada DPD: Cresemba

For country-of-origin details on select listings, see Canada.

Ready to proceed? You can request this medicine with prompt, express shipping and US shipping from Canada after your prescription is verified. This page is informational and not medical advice; talk to your clinician for personal guidance.