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Darzalex (daratumumab) is a monoclonal antibody used to treat multiple myeloma, a type of blood cancer. It works by targeting CD38, a protein on cancer cells, helping the immune system destroy them.
Benefits
• Effective in treating multiple myeloma
• Can be used alone or in combination with other therapies
• Delays cancer progression
• May help extend survival
Dosage
• Initial dose is 16 mg/kg once weekly for several weeks
• Then reduced to every two weeks, then monthly
• Given by intravenous infusion or subcutaneous injection
• Dosage depends on body weight and treatment stage
Warnings and Precautions
• May cause infusion-related reactions
• Monitor blood counts regularly
• Use caution in people with respiratory issues
• Blood type tests may be affected during treatment
Usage Instructions
• Administered in a clinical setting by a healthcare provider
• Premedications like steroids and antihistamines are often given
• Stay under observation during and after infusion
• Report breathing difficulties or chest tightness immediately
Storage Information
• Stored in the clinic per refrigeration guidelines
• Do not self-store or self-administer
• Keep out of direct sunlight
• Must be handled by professionals
Common Side Effects
• Infusion reactions
• Fatigue
• Cough
• Low blood cell counts
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Do I need to stop treatment if I have an infusion reaction?
Not always. Many reactions can be managed with medications and slowing the infusion rate. Future doses may be adjusted.
Can Darzalex be taken at home?
No, it must be administered by healthcare professionals in a controlled setting. Monitoring is essential during infusion.
Does Darzalex interfere with blood tests?
Yes, it can affect blood typing and screening. Inform labs and healthcare providers before transfusions or surgery.
How long is Darzalex treatment?
Duration varies. Treatment can continue for months or even years depending on your response and tolerance.
Can Darzalex be combined with chemotherapy?
Yes, it’s often used alongside other medications like lenalidomide or dexamethasone to enhance its effect.
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