Entocort® Enema for Ulcerative Colitis

This rectal corticosteroid is used for distal ulcerative colitis. It targets inflammation close to the source with local action. You can review options, compare pricing, and see ways to pay without insurance with US shipping from Canada.

What Entocort Is and How It Works

Entocort® enema contains budesonide, a glucocorticoid designed for local effect in the rectum and lower sigmoid colon. As a topical corticosteroid, it quiets inflammatory pathways in the mucosa. That local focus limits systemic exposure compared with many oral steroids. This helps reduce rectal bleeding, urgency, and tenesmus in distal disease.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This budesonide rectal enema is formulated to be retained after administration. Budesonide undergoes extensive first-pass metabolism, which may further minimize whole-body steroid exposure. Official labeling and your prescriber’s guidance should direct all use.

Who It’s For

The treatment is indicated for mild to moderate distal ulcerative colitis, including proctitis and proctosigmoiditis. Patients with disease limited to the rectum and nearby sigmoid segment may benefit from targeted rectal therapy. Some may use it alone, or alongside aminosalicylates when appropriate.

People with known hypersensitivity to budesonide should not use it. Those with active systemic infections, untreated fungal, tuberculosis, or certain viral infections require careful evaluation. Use caution with significant liver impairment or if long-term systemic steroid use has occurred. Children and pregnant or breastfeeding individuals should consult a healthcare professional, as suitability depends on individual risk and benefit. This guidance is general and does not replace the official label.

Some patients instead use an aminosalicylate, or reserve rectal steroids for flares. If a different inflammatory bowel condition is suspected, diagnosis should be confirmed before therapy is started. For broader context on treatment classes, see Ulcerative Colitis and the Gastrointestinal category.

Dosage and Usage

Follow the prescribed schedule on your label. Rectal budesonide is commonly given once daily, often at bedtime, to support retention. Do not change dose or frequency without talking to a clinician. If directions differ from the general points below, always follow your specific instructions.

• Preparation: Shake the bottle gently if directed. Wash hands before and after use.
• Position: Lie on left side with right knee flexed, or as instructed by your clinician.
• Insertion: Remove cap, lubricate the applicator if provided, and insert the tip gently.
• Administration: Squeeze steadily to instill the liquid. Avoid force if pain occurs.
• Retention: Remain lying for several minutes. Retain the enema as long as possible.

If your regimen includes other rectal medicines, your prescriber may sequence them to optimize contact time. Do not share applicators. If irritation persists, contact the prescriber who manages your inflammatory bowel disease. For practical background on comparable rectal therapies, you can review Pentasa Medication and comparisons such as Asacol Vs Pentasa and Asacol Vs Lialda.

Strengths and Forms

Availability can vary by market. A commonly published presentation is budesonide enema 2 mg per unit for rectal use. Packs may include multiple single-use bottles and applicators. Check your label for the exact presentation provided.

Missed Dose and Timing

If a dose is missed and it is close to the next scheduled time, skip the missed dose. Do not double up. Resume the regular schedule at the next dosing time. If frequent misses occur, ask your prescriber about timing strategies to support retention and adherence.

Storage and Travel Basics

Store upright and keep the carton closed to protect from light, as directed by the label. Typical guidance is to keep at controlled room temperature and avoid freezing. Keep out of reach of children and pets. Do not use if the seal is broken or the liquid is discolored.

For travel, pack doses in original packaging with the prescription label. Keep a copy of your prescription and the prescriber’s contact information. During flights, place medicines in carry-on bags to avoid extreme temperatures. Your order is handled with care; temperature-controlled handling when required supports product integrity in transit. If your trip spans several weeks, plan refills ahead so you have sufficient supply.

Benefits

This medicine delivers steroid therapy directly to inflamed rectal tissue. Local delivery may reduce systemic steroid exposure compared with many oral options. Patients often find the regimen convenient at bedtime, which can support retention time. Symptom relief may include reduced rectal bleeding, less urgency, and improved stool frequency in distal disease.

When used as prescribed, Entocort Enema can complement aminosalicylates or serve as a targeted option during flares. The treatment class is commonly part of a step-wise plan that adapts to disease extent and response. Your care team determines how it fits into your overall plan.

Side Effects and Safety

• Rectal discomfort or irritation
• Abdominal cramps or bloating
• Nausea or gas
• Headache or dizziness
• Throat irritation after administration

Systemic steroid effects are less common with rectal budesonide but can still occur. Serious effects may include allergic reactions, signs of adrenal suppression, worsening infection, or severe abdominal pain. Contact a clinician promptly if severe or unusual symptoms occur. Long-term or high-dose steroid exposure may affect bone health, eyes, mood, or glucose; your prescriber weighs these risks against benefits.

Drug Interactions and Cautions

Strong CYP3A4 inhibitors can raise budesonide concentrations. Examples include ketoconazole, itraconazole, clarithromycin, certain HIV medicines, and grapefruit juice. Additional immunosuppressants may increase infection risk. Consider potential interactions with anticoagulants, antidiabetic drugs, and other steroids.

Avoid live vaccines while using significant immunosuppressive therapy. Tell your prescriber about liver disease, glaucoma, cataracts, osteoporosis, or a history of steroid effects. If surgery or severe illness occurs, let healthcare professionals know that you use a corticosteroid, even rectally.

What to Expect Over Time

Rectal steroid therapy may calm rectal bleeding and urgency as inflammation subsides. The response pattern varies by extent of disease and adherence to the regimen. Some patients transition to maintenance options once symptoms improve. If results are limited, your prescriber may adjust the plan, add an aminosalicylate, or consider another local therapy. Adherence, correct technique, and retention time can influence effect.

Compare With Alternatives

Two common alternatives for distal disease include a budesonide foam and a mesalamine enema. Foam can be easier to retain for some patients, while mesalamine offers a non-steroid option.

• Uceris® Rectal Foam for localized budesonide delivery
• Pentasa® Enema for mesalamine-based therapy

Another option for select patients is a mesalamine suppository for very distal disease, such as Salofalk suppositories. For background on aminosalicylate choices, see Delzicol Vs Asacol.

Pricing and Access

We list current options so you can compare formulations and see availability. If you are looking to Buy budesonide enema, you can view the product page for details and place an order through our secure checkout. Canadian pricing with US delivery from Canada may offer meaningful savings for cash-pay buyers. For general cost education, see Drug Costs Without Insurance. Encrypted checkout protects your information throughout the process.

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Availability and Substitutions

Supply can vary by formulation and pack size. If your selected option is unavailable, a prescriber may recommend a suitable alternative in the same class or an aminosalicylate. When appropriate, a Generic budesonide enema may help lower out-of-pocket expenses. Any change requires a valid prescription and professional oversight.

Patient Suitability and Cost-Saving Tips

Good candidates typically have distal ulcerative colitis with symptoms near the rectum and lower sigmoid. Patients with widespread colitis might need additional therapies to reach higher segments. Those with active systemic infections or uncontrolled comorbidities may need different approaches. If sensitivities to corticosteroids exist, discuss options with the prescriber.

To manage costs, consider multi-month supplies when approved, which can reduce per-unit expenses. Set refill reminders so you do not run short during travel or flares. Ask whether a formulary alternative could meet your goals. If you have questions about Entocort Enema cost, compare pack sizes and consider whether a generic or different formulation fits your plan.

Questions to Ask Your Clinician

• Is a rectal steroid suitable for my disease location and severity?
• How long should this course last before reassessment?
• What technique tips can improve retention and comfort?
• Could I combine this with an aminosalicylate or switch later?
• Which interactions should I avoid during treatment?
• What signs mean I should contact the clinic promptly?
• How will follow-up and monitoring be managed?

Authoritative Sources

For official details, consult these resources:

• DailyMed: Budesonide Rectal Foam
• Health Canada Drug Product Database
• DailyMed: Budesonide

Ready to proceed? Place your order now for prompt, express shipping with temperature-controlled handling when required. Ships from Canada to US. This page is informational and does not replace your prescriber’s advice or the official label.