Mayzent® Tablets for Multiple Sclerosis

Mayzent® is siponimod, an oral therapy for relapsing forms of multiple sclerosis. This page explains how it works, who it may suit, and how to access it with US delivery from Canada. Details on Mayzent without insurance support planning and discussions with a prescriber.

What Mayzent Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing. Siponimod tablets are sphingosine 1-phosphate (S1P) receptor modulators. The treatment reduces the movement of certain white blood cells out of lymph nodes. By limiting those cells from entering the central nervous system, it can reduce relapses and new MRI lesions in relapsing multiple sclerosis.

This medicine is approved for relapsing forms of MS, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. Before starting, a CYP2C9 genotype test is required to guide maintenance dosing. An eye exam is often recommended to check macular health, and an electrocardiogram may be considered in those with certain heart conditions. Clinicians usually confirm varicella zoster immunity and update non-live vaccines as needed.

Who It’s For

This therapy is intended for adults with relapsing forms of MS, including those with active secondary progressive disease. Mayzent MS treatment may not be appropriate for people with CYP2C9*3/*3 genotype. It can be unsuitable in certain cardiac rhythm disorders without a pacemaker, recent heart attack or stroke, or unstable angina. People with a history of uveitis or diabetes may have a higher risk of macular edema and need closer monitoring.

Those with active infections should wait until recovery. Discuss pregnancy plans with a prescriber, as this treatment can harm a fetus. For broader context on the condition, see our category page for Multiple Sclerosis or browse Neurology medicines.

Dosage and Usage

Therapy starts with a short, one-time dose-escalation period. The starter schedule gradually increases to a once-daily maintenance dose. The maintenance level depends on the CYP2C9 genotype that is checked before therapy. Take the tablets at the same time each day, with or without food. Swallow whole with water; do not crush, break, or chew. If you are switching from another disease-modifying therapy, your prescriber will determine the appropriate timing and any washout needs.

Some patients with preexisting cardiac conditions or who take heart rate–lowering drugs may need first-dose observation. Your care team will advise whether in-clinic monitoring is appropriate. Always follow the official prescribing information for exact schedules and precautions.

Strengths and Forms

Siponimod 2 mg tablets are used as part of maintenance treatment. The product is available as film‑coated tablets in multiple strengths, commonly including 0.25 mg, 1 mg, and 2 mg, and as a starter pack for the initial dose escalation. Availability can vary by pack size and country of origin.

Missed Dose and Timing

Mayzent medication has specific guidance if doses are missed during the starter period or after you reach maintenance. During the initial escalation days, missing doses often means restarting the titration. After maintenance is established, longer interruptions may also require retitration. The exact rules differ by how many consecutive doses are missed and when. Consult the official label or your prescriber for instructions that fit your situation.

Storage and Travel Basics

Store the tablets at room temperature and keep them in the original packaging to protect from moisture. Keep out of reach of children and pets. For travel, carry the medicine in your hand luggage with the pharmacy label visible. Pack extra for delays and avoid extreme heat or cold. For cross-border trips, a copy of your prescription can help with security checks. Our partners use temperature-controlled handling when required. Dispose of unused or expired tablets according to local guidance.

Benefits

This treatment offers a once-daily oral option for relapsing MS. It can lower relapse frequency and reduce new inflammatory activity seen on MRI. People with active secondary progressive disease may also see slowed progression. Siponimod MS medication can be used long term when tolerated and effective. Compared with injectables or infusions, tablets may feel simpler for some routines. For brain health perspectives, explore World Brain Day A Commitment and World Brain Day 2023 Prioritizing.

Side Effects and Safety

• Headache or dizziness
• High blood pressure
• Diarrhea or nausea
• Abnormal liver tests
• Respiratory symptoms such as cough
• Back pain
• Bradycardia around treatment initiation
• Swelling of hands, ankles, or feet

Serious risks can include infections, macular edema (vision changes), severe bradyarrhythmia or conduction abnormalities, posterior reversible encephalopathy syndrome, liver injury, seizures, and rare cases of progressive multifocal leukoencephalopathy. The treatment may increase skin cancer risk, so skin checks are advisable. Live vaccines should be avoided during therapy and for a time after stopping. Effective contraception is recommended during treatment and for at least 10 days after the last dose. Seek urgent care for severe chest pain, fainting, sudden vision loss, or signs of severe infection.

Drug Interactions and Cautions

Siponimod is metabolized by CYP2C9 and CYP3A4. Certain combinations of strong or moderate inhibitors or inducers can significantly alter exposure, and may be contraindicated based on genotype. Drugs that slow the heart, such as certain beta blockers, non‑dihydropyridine calcium channel blockers, or antiarrhythmics, require careful assessment. Combining with other immunosuppressants can increase infection risks. Avoid live attenuated vaccines during treatment and for a period afterward. Always review your medication list, including over‑the‑counter products and herbal supplements, with a prescriber.

What to Expect Over Time

During the starter period, some people notice a lower heart rate. This typically stabilizes as the dose reaches maintenance. Over months, the goal is fewer relapses and less new MRI activity. Regular blood tests, eye checks, and blood pressure monitoring help track safety. If the therapy is stopped for several days, retitration may be needed before restarting. Consistent daily dosing, reminders, and aligning doses with daily routines support adherence.

Compare With Alternatives

Oral S1P modulators such as Gilenya are alternatives within the same class, though dosing and monitoring differ by product. B‑cell therapies like Kesimpta are injection options that target a different mechanism. Prescribers consider disease activity, comorbidities, imaging, and lifestyle preferences when choosing among these therapies.

Pricing and Access

Looking up the Mayzent price helps compare Canadian options with typical U.S. cash‑pay levels. Ordering through Border Free Health provides access to licensed partners, with fulfilment that Ships from Canada to US. See national-origin details under Canada. To check live availability and current pricing, add the item to your cart and follow secure prompts. For extra ways to save, review seasonal Promotions. Checkout is encrypted to protect your information.

Savings CTA: Compare Canadian pricing and see potential cash‑pay differences before requesting fulfilment. Pricing CTA: View today’s pricing in your cart and proceed when ready.

Availability and Substitutions

Stock levels can vary by pack size and strength. If a specific presentation is unavailable, a prescriber may recommend another appropriate option in the same class or a different mechanism. Decisions depend on clinical history and monitoring needs. Our Multiple Sclerosis collection highlights other therapies that clinicians often consider.

Patient Suitability and Cost-Saving Tips

Candidates include adults with relapsing forms of MS who can complete CYP2C9 genotyping and routine safety checks. People with certain heart rhythm disorders, recent major cardiovascular events, or a contraindicated genotype should avoid treatment. To manage costs, consider multi‑month supplies, set refill reminders, and coordinate lab visits to minimize extra trips. Discuss assistance programs with your prescriber’s office. Shoppers comparing Siponimod Canadian pricing often review per‑tablet values as well as total course costs. One more note: many compare options without insurance and then choose multi‑month refills to reduce fees per fill.

Questions to Ask Your Clinician

• Starter plan details: What baseline tests and first‑dose steps are recommended?
• Safety monitoring: How often should labs, blood pressure checks, and eye exams occur?
• Vaccinations: Which non‑live vaccines are advised before starting therapy?
• Contraception: What precautions are needed during treatment and after stopping?
• Interactions: Which current medicines raise concerns with this therapy?
• Relapse plan: How should potential relapses be handled while on treatment?
• Transitioning: If stopping, what is the plan to prevent disease rebound?

Authoritative Sources

Novartis Mayzent (US site)FDA DailyMed: Mayzent Prescribing InformationHealth Canada Drug Product Database: Siponimod

Ready to order with prompt, express shipping and US shipping from Canada? Add to cart, upload your prescription, and our team will coordinate fulfilment. This information is educational and does not replace professional medical advice.