Myleran® Tablets for Chronic Myeloid Leukemia

What Myleran Is and How It Works

Myleran® is the brand name for busulfan, an oral chemotherapy in the alkylating agent class. It helps control abnormal white blood cell growth in chronic myeloid leukemia (CML). This page explains what it does, who it may suit, and how you can manage treatment details with confidence and US delivery from Canada, including options if you are paying without insurance.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine works by forming cross-links with DNA in rapidly dividing cells. That action can slow or stop the growth of leukemia cells. The treatment is often used when targeted therapies are not appropriate or have lost effect, or when a prescriber directs a specific care plan. The generic name is busulfan. Always follow your clinician’s instructions and the official label.

To learn more about related conditions, you can browse our Leukemia and Oncology categories, or visit the condition page for Chronic Myeloid Leukemia.

Who It’s For

This treatment is used for adults with CML under a prescriber’s supervision. It may be selected when other therapies are not suitable, no longer effective, or are not tolerated. Pediatric use requires specialist oversight.

It is not appropriate during pregnancy. People trying to conceive should discuss risks and timing. Those with severe bone marrow suppression, active uncontrolled infections, or significant liver or lung disease need careful evaluation before starting. Your healthcare professional will assess medical history, current medicines, and lab results.

Dosage and Usage

Busulfan dosing varies and is individualized based on blood counts and clinical response. Doses and schedules are adjusted by the prescriber to target therapeutic goals while minimizing toxicity. Do not change your dose unless your clinician tells you to do so.

General use tips:

• Follow the exact schedule on the label.
• Swallow tablets with water and take consistently as directed.
• Wash hands after handling; caregivers may use gloves when appropriate.
• Keep a dosing diary and record any symptoms.

Clinicians monitor complete blood counts and other labs at regular intervals. If counts drop too low or side effects appear, your care team may pause or modify therapy. When uncertain, defer to the official label and your prescriber’s advice. For education, many patients search for guidance on Busulfan dosing, but individual management should remain clinician-directed.

For broader background on targeted CML therapies, see our articles What Is Nilotinib, Exploring Dasatinib Mechanism, and How Bosulif Treats Cml.

Strengths and Forms

The brand has been available as the Myleran 2 mg tablet. Generic busulfan tablets are marketed in some regions. Presentation and manufacturer can vary by country and by supplier. Availability may change over time and by jurisdiction.

Ask your prescriber and pharmacist which presentation matches your prescription. If the exact brand is not available, your pharmacist can coordinate with your clinician on appropriate options.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is close to the next scheduled time. If it is almost time for the next dose, skip the missed dose. Do not double doses. If vomiting occurs shortly after a dose, contact your prescriber for specific guidance. Repeated missed doses should be discussed with your care team, as consistency helps with safe monitoring.

Storage and Travel Basics

Store tablets at room temperature per the label, away from excess moisture and heat. Keep them in the original container with the label intact and out of reach of children and pets. Do not store in the bathroom. When traveling, carry your medicine in a hand luggage compartment. Keep a copy of your prescription and your prescriber’s contact information. Use a secure pill container with a child-resistant closure.

Follow local guidance for transporting chemotherapy. If you are using multiple medicines, separate them to avoid mix-ups. Pharmacy packaging can support temperature-controlled handling when required. Check the label and your pharmacist’s instructions if you are unsure about specific storage limits.

Benefits

This therapy can help reduce elevated white blood cell counts in CML. It may shrink an enlarged spleen and improve related symptoms as directed by your prescriber. Oral dosing can be convenient for some people compared with hospital-based infusions. The medicine has a long clinical history, which informs monitoring strategies and supportive care.

Individual outcomes vary. Your care team will track blood counts and adjust the plan to balance benefit and safety. Supportive medicines may be used to address nausea or other effects when appropriate.

Side Effects and Safety

Like all chemotherapy, this treatment can cause side effects. Discuss the plan for monitoring and supportive care before starting. To learn about Myleran side effects in depth, refer to the official label and speak with your clinician.

• Lowered blood counts, including neutropenia and thrombocytopenia
• Nausea, vomiting, poor appetite, or weight changes
• Mouth soreness or ulcers
• Diarrhea or constipation
• Skin darkening or rash
• Fatigue or dizziness

Serious risks may include severe bone marrow suppression, infections, lung toxicity (busulfan-related pneumonitis), liver problems including veno-occlusive disease, seizures at high exposures, infertility, and potential harm to a developing fetus. Your clinician may prescribe seizure prophylaxis in some settings. Report fever, bleeding, shortness of breath, or right upper abdominal pain urgently. Regular lab monitoring is essential throughout therapy.

Drug Interactions and Cautions

Certain medicines and supplements can change busulfan exposure. Review every product you use with your prescriber and pharmacist.

• Azole antifungals and metronidazole may increase busulfan levels
• Acetaminophen can reduce glutathione and affect clearance
• Phenytoin and other enzyme inducers may alter metabolism
• Live vaccines should generally be avoided during active chemotherapy

Alcohol use, smoking, and herbal products can add risks. Inform your care team about all over-the-counter products. For quick reference on Busulfan interactions, consult the official labeling and ask your healthcare professional for personalized guidance.

What to Expect Over Time

Blood counts are checked regularly. Your prescriber may adjust dosing or pause therapy based on results and tolerability. Some people may notice symptom improvement gradually as counts normalize. Others require careful dose modifications to limit side effects. It is common to use supportive care such as anti-nausea medicines. Keep all laboratory appointments and promptly report new symptoms. Do not alter the schedule outside your care team’s instructions.

Many patients benefit from written plans that include who to call, when to repeat labs, and how to manage missed doses or new symptoms. Bringing a treatment journal to visits can help track changes and questions.

Compare With Alternatives

Busulfan is an alkylating agent. Many people with CML start with tyrosine kinase inhibitors (TKIs), such as imatinib or dasatinib, depending on clinical factors. If a TKI is appropriate for you, your prescriber will help select one based on your history and lab results.

Two commonly used TKIs available on our site include Gleevec and Sprycel. Your clinician will weigh benefits, risks, and tolerability. Each option has distinct monitoring needs and potential interactions. If a TKI is not suitable, your care team may discuss busulfan tablets or other regimens.

Pricing and Access

You can review availability and consider ways to save compared with typical U.S. cash-pay rates. Many patients ask about Busulfan tablets price and how dispensing works. We support secure checkout and coordination with your prescriber for verification. If you are comparing options, you can also Order Myleran online once your prescription is confirmed.

We source Canadian pharmacy pricing with US delivery from Canada. To explore seasonal offers, visit our Promotions page. For condition-focused browsing, see our Hematology and Cancer categories, or check origin details under Canada.

Availability and Substitutions

Stock can vary. If a specific brand is not available, your pharmacist may coordinate with your prescriber about an appropriate generic busulfan tablet or an alternative plan. Substitutions are made only with prescriber approval. We do not list restock dates; please check back or consult your care team for suitable interim options.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with CML who need an oral option outside first-line TKIs or who require a tailored regimen. It may not be appropriate for those with uncontrolled infections, severe marrow suppression, or certain organ impairments without specialist oversight. Contraception is advised during treatment and for a period after, as directed by your clinician.

• Multi-month supplies: ask about longer fills if stable
• Refill reminders: set calendar alerts before you run low
• Care coordination: align lab dates with refill timing
• One pharmacy: keep records consistent to avoid mix-ups

Discuss supportive care, travel plans, and work schedules with your team to help maintain adherence and safety.

Questions to Ask Your Clinician

• What goals are you targeting with this therapy, and how will we measure progress?
• How often will I need blood tests, and which results trigger dose changes?
• Which side effects should prompt immediate calls or urgent care?
• What precautions should I take at home to reduce infection risk?
• Are there interactions with my current medicines or supplements?
• What are the reproductive and fertility considerations for me or my partner?

Authoritative Sources

For full details, review official labeling and regulatory resources:

• FDA DailyMed: Busulfan Tablets
• Health Canada DPD
• FDA DailyMed Home

Ready to proceed? You can start your order with prompt, express shipping and US delivery from Canada after your prescription is verified. This page is informational and not a substitute for medical advice.