NexGard Combo® Topical Solution for Cats

Treat fleas, ticks, mites, and worms in cats with a single monthly application. This page explains how this medicine works, who it suits, and how to use it safely, with US delivery from Canada. You can check out as a cash-pay customer without insurance.

What NexGard Combo Is and How It Works

NexGard Combo® is a prescription spot-on solution for cats and kittens. It combines esafoxolaner, eprinomectin, and praziquantel for broad-spectrum parasite control. It kills adult fleas and certain ticks, prevents heartworm disease, treats ear mites, and targets common intestinal worms, including roundworms, hookworms, and tapeworms.

NexGard Combo for Cats works through contact with the skin and distributes across the coat. Esafoxolaner, an isoxazoline, disrupts nerve signals in fleas and ticks. Eprinomectin acts on heartworm larvae and other nematodes. Praziquantel affects tapeworms’ protective surfaces. Together, this treatment helps protect cats in one monthly dose.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

For flea-heavy environments, pair parasite control with home cleaning. See tips and context in our article Flea Tick And Worm. For condition background, review our Fleas page.

Who It’s For

This medicine is for cats and kittens when your prescriber recommends protection against fleas, ticks, ear mites, heartworm, and intestinal worms. Most labels allow use from 8 weeks of age and a minimum weight threshold. Safety in breeding, pregnant, or lactating cats may not be established; ask your veterinarian.

NexGard Combo Spot-On for Cats should be used with caution in cats with seizure history or neurologic disorders. Isoxazoline-class products can, in rare cases, be associated with tremors or seizures. Do not use in sick or underweight animals unless a veterinarian directs it.

Dosage and Usage

Apply the full pipette to intact skin once every month. Part the hair at the base of the skull until skin is visible, and empty the entire contents directly on the skin. Avoid contact with the application site until dry. Do not allow oral ingestion. Do not bathe or shampoo the cat for a short period after use per the label; if bathing is needed, discuss timing with your veterinarian.

Use weight-based pipettes as directed on the carton. Administer on the same date each month to maintain coverage, especially for heartworm prevention. If your household includes other pets, separate them until the site is dry to prevent grooming of the area. Keep children away from the site until it is dry.

Package sizes vary by market. Multi-month cartons are common, and some owners prefer to keep a calendar reminder for each month’s dose. Ask your prescriber about year-round protection in heartworm areas.

Strengths and Forms

This treatment is supplied as single-use spot-on pipettes in weight bands for cats. Common presentations include pipettes for small cats (for example, 0.8–2.5 kg) and medium cats (for example, 2.5–7.5 kg). Availability can vary by region and time.

For certain cats, your prescriber may recommend the NexGard Combo 2.5-7.5 kg pipette when the body weight fits that range. Always match the weight band on the carton to your cat’s current weight.

Missed Dose and Timing

If you miss a monthly dose, apply it when remembered and resume the regular monthly schedule. Do not apply more than one full pipette within a month unless your veterinarian advises it. Keeping a phone reminder or a written note can help prevent gaps that may reduce protection.

Storage and Travel Basics

Store pipettes in the original foil until use. Keep in a dry place at room temperature and out of direct sunlight. Do not puncture or open a pipette until you are ready to use it. Keep away from heat sources and open flames.

When traveling, pack the next dose in its sealed pouch with the carton section that shows the prescription label. Place it in a zip bag to prevent leaks. Keep out of reach of children and other pets. If flying, carry it in your hand luggage to avoid extreme temperatures. For parasite risk by destination, review local guidance or ask your veterinarian.

Benefits

This broad-spectrum therapy helps protect cats against multiple parasites with one monthly application. It controls fleas and ticks on the cat and helps prevent heartworm disease when used as directed. It also treats ear mites and common intestinal worms, including tapeworms, which reduces the need for multiple separate products.

Single-dose monthly use improves consistency. It can be helpful for cats that resist tablets. Many owners find the single pipette approach easier to schedule alongside routine care visits and reminders.

Side Effects and Safety

• Application site issues: temporary hair changes, redness, or mild irritation
• Digestive signs: vomiting, soft stool, decreased appetite
• Behavioral changes: lethargy or restlessness in some cats

Serious but uncommon reactions may include tremors, ataxia, or seizures, with or without prior history. If your cat shows concerning neurologic signs, contact a veterinarian promptly. Prevent grooming of the application site until dry. If vomiting persists, your veterinarian may suggest supportive care; medicines such as Cerenia are sometimes used for vomiting in cats when clinically appropriate.

Drug Interactions and Cautions

Tell your veterinarian about all medicines and supplements your cat receives. Use caution with other topical or systemic parasite products, unless your prescriber recommends a specific combination. Take care with concurrent therapies that can affect the nervous system. Avoid use in animals with known hypersensitivity to isoxazolines or other listed ingredients.

Do not apply to broken skin. Prevent contact with the eyes and mouth. Wash your hands after applying. If there is household flea allergy dermatitis or skin infection from scratching, your clinician may treat secondary issues, potentially with antibiotics like Clavamox, when appropriate.

What to Expect Over Time

After application, the treatment spreads across the skin and coat. Flea control typically improves within the first days, and monthly dosing helps break the life cycle. For heartworm prevention, staying on a consistent monthly schedule is essential throughout risk seasons. You may not see visible worms; prevention works quietly in the background.

Most cats tolerate the product well. Some may experience mild, short-lived side effects at the site or transient digestive upset. If issues recur or persist, speak with your veterinarian about next steps or alternative approaches.

Compare With Alternatives

Some cat owners consider separate products for different parasites instead of a single broad-spectrum therapy. A veterinarian-guided dewormer like the option discussed in Drontal For Cats can target intestinal worms only. For rapid flea kill, see our article on one-time options in Capstar Flea Treatment. For broader background on infestation risks, visit our Heartworm page.

Pricing and Access

We provide Canadian-sourced cartons with transparent pricing and a secure checkout. You can browse NexGard Combo Online and compare options suited to your cat’s weight band. If you are looking for a deal, check for a NexGard Combo Discount when available.

US costs may differ from Canadian rates. Your order includes clear fulfillment steps and status updates. We also offer category browsing for quick comparisons across Pet Medications. Savings can vary by pack size and prescription details. For occasional offers, see our Promotions page. Fulfilment is handled by licensed partners, and checkout uses encrypted processing. Delivery typically Ships from Canada to US.

Availability and Substitutions

Stock can vary by weight band and pack size. If your preferred carton is unavailable, your prescriber may recommend an alternative parasite plan. Some owners choose practical sizes such as a NexGard Combo 3 Pack for initial use or a longer supply for convenience. Follow your veterinarian’s advice if a substitution is suggested.

Patient Suitability and Cost-Saving Tips

This treatment suits many indoor and outdoor cats when a veterinarian confirms the need. It may not suit cats with certain neurologic histories or those that are pregnant or nursing unless specifically advised. For multi-cat households, apply to each cat based on individual weight, not shared dosing.

To save on overall costs, consider multi-month cartons when it fits your plan. Set refill reminders a week before the next monthly dose to avoid gaps. If total parasite risk is seasonal in your area, ask your clinician whether year-round prevention is appropriate. When ready, you can Order NexGard Combo through Borderfreehealth after your prescription is verified.

Questions to Ask Your Clinician

• Weight band choice: which pipette size matches my cat today?
• Parasite risks: is year-round prevention recommended where we live?
• Bathing and grooming: how long should I wait after application?
• Side effects: what signs are urgent and which can be monitored?
• Other products: should I avoid combining with specific flea or worm treatments?

Authoritative Sources

European Medicines Agency EPAR

Health Canada Drug Product Database

Boehringer Ingelheim Animal Health

Ready to proceed with Borderfreehealth? Start your secure checkout for prompt, express shipping with US shipping from Canada. This information is educational and not a substitute for veterinary advice; always follow your prescriber’s directions.