Nordimet® Prefilled Pen for Rheumatoid Arthritis

Nordimet® is a once-weekly methotrexate pen for certain autoimmune conditions. This overview helps you understand safe use, dosing basics, and access with US delivery from Canada, including options without insurance. You can review key safety points before you order or travel.

What Nordimet Is and How It Works

Nordimet® delivers methotrexate in a single-use, subcutaneous prefilled pen. The active ingredient reduces immune activity that drives joint and skin inflammation. It interferes with folate-dependent pathways in rapidly dividing cells, which can calm overactive immune responses in rheumatoid arthritis and severe psoriasis. The pen is designed for steady weekly dosing under a prescriber’s guidance.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This Methotrexate prefilled pen allows at-home administration after training. It should be used exactly as directed on a once-weekly schedule. Regular monitoring is important to check blood counts, liver health, and kidney function, as outlined in the official labeling.

Who It’s For

This therapy is used for adults with active rheumatoid arthritis who have not responded adequately to initial treatments. It is also used in severe, recalcitrant psoriasis when other options are unsuitable or ineffective. In some cases, clinicians use it for polyarticular juvenile idiopathic arthritis; dosing and suitability depend on specialist guidance.

This Methotrexate injection pen should not be used during pregnancy or breastfeeding. It is not suitable for people with severe liver disease, significant alcohol use disorder, blood cell disorders, severe kidney impairment, active infections, immunodeficiency, or known hypersensitivity to methotrexate. Your healthcare professional will review your history and current medicines before prescribing.

Dosage and Usage

Use the Nordimet injection pen once weekly on the same day each week. Do not take it daily. Your prescriber will determine the starting dose and any adjustments. Many clinicians also recommend folate supplementation; follow your clinician’s instructions.

General administration tips:

• Pick a weekly day and set reminders
• Inject into abdomen or thigh, rotating sites
• Clean the skin and allow it to dry
• Use a new single-use pen for each dose
• Never split doses across days

If your instructions differ from these general points, follow the official label and your prescriber’s guidance.

Strengths and Forms

The pen is supplied as a single-use, subcutaneous device. Availability may vary by strength and pack size. Common options cover a range from lower weekly doses up to higher weekly doses used in some patients, in stepwise increments allowing careful titration. This format supports consistent weekly therapy and minimizes preparation steps.

Ask your prescriber which dose is appropriate for your condition and monitoring plan. Pharmacies may stock different presentations at different times. If a specific strength is not available, your prescriber may choose an alternative strength or an equivalent product.

Missed Dose and Timing

If you miss a weekly dose, contact your clinician for advice. As a general rule, do not double up the next dose. If the next scheduled day is close, many prescribers advise skipping the missed dose and returning to your usual day. Keep track with a calendar or app to maintain a steady weekly routine.

Storage and Travel Basics

Store the pen at typical room conditions as indicated on the package insert, and keep it in the original carton to protect from light. Do not freeze. Keep out of reach of children. When traveling, carry the pen in your hand luggage, along with your prescription or a travel letter if requested. Avoid excessive heat. A small insulated pouch can help maintain appropriate conditions during transit.

Used and unused pens should be kept away from pets and children. If you travel across time zones, choose a weekly day based on your home schedule or discuss adjustments with your prescriber. Dispose of used pens properly as sharps.

Pen Handling and Sharps Disposal

Read the device instructions each time before use, especially if you are new to the pen. Typical steps include removing the cap, placing the pen against the skin, and pressing and holding the activation button for the full duration indicated by the device. Keep the device steady until the indicator shows completion. Do not attempt to recap a used needle. Place the used pen in an FDA-cleared sharps container or a heavy-duty alternative per local guidance. Follow local rules for sharps disposal.

Benefits

This treatment supports once-weekly dosing, which many people find easier to remember than multiple daily tablets. The prefilled device removes the need to draw up medicine from a vial. The design aims to reduce preparation time and support consistent administration. At-home use, after training, can reduce clinic visits for injections and may fit a weekly self-care routine.

Side Effects and Safety

• Nausea or stomach upset
• Mouth sores
• Fatigue
• Headache or dizziness
• Elevated liver enzymes
• Skin rash or photosensitivity
• Hair thinning

Serious risks can include bone marrow suppression, severe infections, liver toxicity, lung inflammation, kidney problems, and severe skin reactions. Stop the medicine and seek urgent care if you develop signs of allergic reaction, severe shortness of breath, unusual bleeding or bruising, or jaundice. Alcohol increases liver risk. Routine lab monitoring helps detect problems early. Avoid live vaccines during therapy unless your clinician advises otherwise.

Drug Interactions and Cautions

Methotrexate may interact with several medicines. Notable examples include trimethoprim-sulfamethoxazole, certain penicillins, NSAIDs, proton pump inhibitors, and other agents that affect the bone marrow or the liver. Combining with other immunosuppressants can raise infection risk. Discuss all prescription medicines, over-the-counter drugs, vitamins, and herbal supplements with your healthcare professional. Limit or avoid alcohol. Review your vaccine plans with your prescriber.

What to Expect Over Time

It may take multiple weeks for joint or skin symptoms to improve. Staying on a consistent weekly schedule helps your clinician assess response and tolerability. Regular blood tests check blood counts, liver function, and kidney function. If you experience nausea, your prescriber may suggest timing strategies or other supportive steps; follow their guidance. Keep logging your doses and any symptoms so you can share a clear picture at follow-up visits.

Compare With Alternatives

Some patients start with or switch to biologic injections when appropriate. Two options we carry include Enbrel Pre Filled Syringe and Stelara Pre Filled Syringe. Selection depends on diagnosis, prior therapies, and monitoring plans. For educational reading on biologics, you can review our article What Is Enbrel Injection Benefits And Safety Guide.

Pricing and Access

We provide Canadian pharmacy options with transparent pricing for this therapy. You can review availability, see typical cash-pay savings, and compare plans if your clinician has prescribed this therapy. We offer US shipping from Canada to help you access treatment through our partner network.

If you are looking for Nordimet Canadian pricing, check the product page for current details and stock status. For coupon updates across therapies, see our Promotions page. Checkout uses encrypted processing to help protect your information.

For broader condition insights, explore our psoriasis community resource World Psoriasis Day 2025 Support Care Awareness, or learn about related dermatology options in Exploring Cosentyx Uses For Clearer Healthier Skin. To see items sourced from Canada, visit the category page Canada.

Availability and Substitutions

Supply can vary by strength. If a specific pen is not available, your prescriber may recommend an alternative formulation or timing until supply improves. If using a methotrexate pen from Canada previously, keep your dosing records handy so your clinician can coordinate substitutions without changes to your weekly schedule unless medically necessary.

Patient Suitability and Cost-Saving Tips

Good candidates are adults with confirmed diagnoses who can follow a weekly plan and attend regular monitoring. People with the contraindications listed above should avoid this therapy. If you are planning pregnancy, discuss a timeline and safe alternatives before starting. Keep alcohol to a minimum or avoid it to reduce liver risk.

Cost-saving ideas include asking your prescriber about multi-month fills when appropriate, setting refill reminders, and aligning lab visits with dispense cycles. If your insurer does not cover this therapy, compare cash pricing on our site with your local options. For those coordinating travel, consider consolidating refills to reduce trips and time away from work.

Questions to Ask Your Clinician

• Weekly plan: Which day and dose are right for me?
• Monitoring: How often will labs be checked?
• Folate: Should I take folic acid and when?
• Interactions: Which medicines or supplements should I avoid?
• Alcohol: What limits are safest for my liver?
• Vaccines: How should I handle upcoming immunizations?
• Family planning: What timing is advised before pregnancy?

Authoritative Sources

FDA Labeling (DailyMed/PI)Health Canada Drug Product DatabaseManufacturer Information

Drug Interactions and Cautions (Additional Notes)

This section reiterates that combining with trimethoprim-sulfamethoxazole can markedly increase bone marrow risk. Some penicillins, PPIs, and NSAIDs may affect levels or toxicity risk. Always consult your prescriber before starting or stopping any medicine.

Label-Aligned Reminders

Use the Nordimet methotrexate pen exactly once weekly unless your prescriber changes the plan. Keep the same weekday when possible. Do not self-adjust the dose. Report any signs of infection promptly. Protect from light and do not freeze.

For clarity, methotrexate pen US shipping details are shown on our checkout page, and prescription required and verified steps apply at processing.

Ready to get started? Add this medicine to your cart for prompt, express shipping. Ships from Canada to US. This content is educational and not a substitute for the official label or medical advice from your clinician.