Omvoh® Injection for Ulcerative Colitis

Omvoh Injection is a prescription biologic for adults with moderate to severe ulcerative colitis. It helps calm gut inflammation by targeting a specific immune pathway. This page explains how it works, how it is given, and how you can arrange US delivery from Canada, including options if you pay without insurance.

What Omvoh Is and How It Works

Omvoh® contains mirikizumab-mrkz, a monoclonal antibody that binds the p19 subunit of interleukin-23 (IL‑23). By reducing IL‑23 signaling, inflammation in the colon may decrease over time. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This therapy is approved for adults with moderately to severely active ulcerative colitis who meet label criteria. Mirikizumab injection is started with an induction phase under clinical supervision, followed by at-home maintenance injections. Treatment decisions, including starting or continuing therapy, should follow the official prescribing information and your prescriber’s guidance.

The medicine is not a steroid. It belongs to the IL‑23 inhibitor class, used in inflammatory conditions. It is designed for long-term control rather than rapid symptom rescue.

Who It’s For

This treatment is indicated for adults with moderately to severely active ulcerative colitis when a prescriber determines it is appropriate. People with a history of serious or opportunistic infections, active tuberculosis, or known hypersensitivity to components may need to avoid it. Your healthcare professional may screen for TB and review vaccination status before starting.

Use caution if you have chronic or recurrent infections, significant liver concerns, or a weakened immune system. Discuss pregnancy, plans to become pregnant, or breastfeeding with your prescriber. Live vaccines are generally avoided during therapy; non-live vaccines may be considered as advised by your clinician.

Dosage and Usage

Therapy typically begins with an induction phase administered by a healthcare professional. The induction step is given by intravenous infusion at scheduled intervals. After induction, patients move to subcutaneous maintenance dosing at home on a regular four-week schedule, if they are responding and the prescriber recommends continuing.

Omvoh IV infusion for induction is performed in a clinic or infusion center. Maintenance usually uses an on-body device, prefilled syringe, or prefilled pen. Do not change your dose or timing without your prescriber’s direction. If the plan changes, follow the label and your clinician’s instructions.

General administration tips for at-home injections: allow the pen to reach room temperature out of the refrigerator, rotate injection sites, and inject in the abdomen, thigh, or upper arm area if instructed. Avoid tender, bruised, or scarred skin. Do not shake devices. If you receive any training materials, review them carefully before your first self-injection.

Strengths and Forms

Availability may vary by fulfillment pharmacy. Common presentations include:

• Prefilled pen for subcutaneous use
• Prefilled syringe for subcutaneous use
• Vial for intravenous infusion during induction

The maintenance devices are typically labeled at Mirikizumab 100 mg/mL. Always check your carton, device, and label instructions for the exact presentation provided to you.

Missed Dose and Timing

If you miss a maintenance dose, administer it as soon as you can. Then continue with the regular schedule from the new date, unless your prescriber gives different instructions. Do not take two doses at once. If you are unsure what to do, contact your clinician or review the official label.

Storage and Travel Basics

Keep pens and syringes in the original carton in the refrigerator. Protect from light. Do not freeze. Do not shake. If a device has been frozen or left outside the recommended conditions, follow the package instructions and contact your pharmacy or prescriber for guidance.

For travel, store devices in an insulated container with cool packs if advised. Keep medicines in your carry-on when flying. Bring your prescription label and a copy of instructions in case security or customs staff request documentation. You can store your supply discreetly at your destination; avoid direct heat and prolonged sunlight exposure.

Pen Handling and Sharps Disposal

Read the device’s step-by-step instructions before use. Wash hands, choose a clean site, and let the alcohol swab dry fully. Press the pen as instructed and hold for the full time until the viewing window indicates completion. If you are using a syringe, follow the labeled technique for skin pinch and angle.

Do not reuse needles or devices. Place used pens, needles, and syringes in an FDA-cleared sharps container immediately after use. When full, follow local rules for disposal. Your healthcare professional or pharmacy can help identify community disposal programs.

If training materials for an Omvoh prefilled syringe or pen are provided, review them and ask your clinician to observe your first at-home dose if possible.

Benefits

This treatment targets a defined immune pathway implicated in ulcerative colitis. It can be used for patients who need an option beyond steroids or conventional agents. At-home maintenance dosing every four weeks may fit a routine once training is complete. Many patients value reduced steroid exposure and a non-oral route that bypasses daily pills.

Side Effects and Safety

• Upper respiratory tract infections
• Headache
• Injection site reactions
• Joint pain
• Rash
• Nausea

Serious risks may include severe infections, hypersensitivity reactions, or infusion-related reactions during induction. Your prescriber may screen for tuberculosis before starting and monitor for signs of infection during treatment. Seek urgent care for symptoms of a serious allergic reaction such as trouble breathing, swelling, or widespread hives.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements you take. Using other biologics or potent immunosuppressants at the same time can increase infection risk. Avoid live vaccines while on therapy. Non-live vaccines may be given if recommended. Report new or worsening infections, fever, weight loss, or night sweats promptly. If you have chronic hepatitis or other significant liver issues, your prescriber may monitor more closely.

What to Expect Over Time

Most patients start with supervised induction, then continue with scheduled maintenance injections. Your clinician will assess symptoms, lab results, and, when appropriate, endoscopic findings to gauge response. Adherence to the timing plan helps maintain benefits. Discuss goals and track changes with a symptom diary. If response plateaus or declines, your prescriber may reassess the plan for you.

During maintenance, some people notice steadier control between doses. An Omvoh maintenance injection every four weeks may simplify routines compared to more frequent dosing schedules from other options. Set reminders so you do not miss planned doses.

Compare With Alternatives

Several approved options are available for moderate to severe ulcerative colitis. A well-known alternative is Stelara, which blocks IL‑12/23. An oral small-molecule option is Tofacitinib XR, a JAK inhibitor. Anti‑TNF agents like Humira are also used in this condition. Your prescriber will consider prior therapies, comorbidities, and monitoring needs when choosing a treatment plan.

Pricing and Access

We offer transparent Canadian options with fulfillment that Ships from Canada to US. If you are comparing plans, look at device type and supply quantity as well as the dispensing pharmacy’s fees. For those evaluating cash-pay approaches, review Prescription Drugs Cost for context on patient expenses.

Ask our team to check Omvoh Canadian pricing and current supply forms before you place your order. For occasional savings opportunities, see our Promotions. Checkout is protected with encrypted processes.

Availability and Substitutions

Supply can vary by device and form. If a specific presentation is not available, your prescriber may recommend an alternative that fits your treatment goals. We cannot guarantee restock dates. Contact support to confirm current options before you arrange payment or travel plans.

Patient Suitability and Cost-Saving Tips

Candidates are adults who meet label criteria and have been evaluated for infections and vaccine status. People with active serious infections, uncontrolled TB, or previous severe hypersensitivity to this therapy should not use it. If you have a complex medical history, your clinician may coordinate care with a gastroenterologist.

To save on overall costs, discuss multi-month supplies with your prescriber if appropriate. Coordinating refills ahead of time can reduce urgent fees. Use calendar reminders for your four-week schedule. Keep documentation in case airlines or border agents request proof of medical need during trips.

Questions to Ask Your Clinician

• Induction plan: Where and how will I receive the first infusions?
• Maintenance device: Pen, on-body injector, or syringe—what do you recommend?
• Monitoring: What labs or check-ins will we use to track response?
• Vaccines: Which vaccines should I get before starting, and which should I avoid?
• Infections: What symptoms should prompt me to call the office?
• Travel: How should I pack and store doses during flights or long drives?

Authoritative Sources

Explore related topics and therapies: learn more about Ulcerative Colitis, compare 5‑ASA options in Asacol Vs Pentasa and Delzicol Vs Asacol, and see items sourced from Canada.

Ready to proceed? You can upload your prescription and place an order with prompt, express shipping and US shipping from Canada. This content is educational and does not replace the advice of your healthcare professional.