Sotyktu® Tablets for Plaque Psoriasis

Sotyktu is a prescription tablet for adults with plaque psoriasis. It targets immune signaling linked to skin inflammation. You can order with US delivery from Canada. This page explains what it is, how it is used, and how to access it without insurance.

What Sotyktu Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Sotyktu® contains deucravacitinib, an oral selective TYK2 inhibitor. By modulating TYK2 within the JAK family, it can reduce signaling from cytokines such as interleukin‑23, interleukin‑12, and type I interferons that drive plaque formation. It is taken once daily and is designed for long‑term management when systemic therapy is appropriate.

Deucravacitinib 6 mg tablets are the approved strength for adults. The treatment is not a steroid and is not a biologic injection. It acts inside immune cells and has a distinct mechanism compared with traditional systemic medicines.

Before starting, your clinician may check for infections, including tuberculosis. They may also review your vaccines and medical history to confirm suitability.

Learn more about the condition itself in our Plaque Psoriasis category, and explore broader skin care options under Dermatology.

Who It’s For

This medicine is indicated for adults with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy. It may be considered when topical agents are not enough or when an oral option is preferred over injections.

Avoid starting during an active serious infection. Discuss any history of recurrent herpes, chronic infections, or tuberculosis exposure. It is not recommended in severe hepatic impairment. Use in pregnancy or while breastfeeding requires a careful risk‑benefit discussion with your prescriber.

For community support and education, see World Psoriasis Day 2025 and Psoriasis Awareness Month.

Dosage and Usage

The typical Sotyktu dosage is one 6 mg tablet by mouth once daily. Take it at the same time each day, with or without food. Swallow the tablet whole. Do not crush or split unless your clinician instructs otherwise.

Choose a time you can maintain consistently, such as breakfast or bedtime. If you take other medicines, separate routine administration steps to keep habits simple. Keep a dosing log or set a reminder on your phone to support adherence.

Your prescriber may request baseline screening for tuberculosis and review your vaccination status before initiation. They may periodically check liver enzymes or lipids per the official prescribing information.

Strengths and Forms

This therapy is supplied as oral tablets. The commonly available strength is 6 mg for adults. Availability can vary by partner pharmacy, packaging, and country of origin. Please note that the strength reference may differ in appearance by manufacturer lot, but the active ingredient and dose remain standardized.

Selection and stock may change, and your prescriber’s directions should always guide your order.

Missed Dose and Timing

If you miss a dose, take it when you remember on the same day. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once. Keeping the tablet in a visible place and using reminders can help reduce missed doses.

Storage and Travel Basics

Store tablets at room temperature in the original container. Keep the bottle tightly closed, protected from moisture, and out of reach of children and pets. Do not use past the labeled expiration date. Avoid storing in bathrooms or cars where heat and humidity can fluctuate.

When traveling, pack enough for your trip plus a few extra days in case of delays. Carry it in your hand luggage with a copy of your prescription. Keep the label visible to simplify security checks. If crossing borders, follow local rules for personal medication transport.

Benefits

This treatment is taken orally once daily, which many find convenient compared with injections or frequent clinic visits. It targets a defined immune pathway linked with plaque formation. The approach may reduce plaque thickness, scaling, and redness over time when taken as directed.

The class has no routine injection‑site concerns and can fit into regular routines. Your clinician can decide whether it suits your goals and health profile.

Side Effects and Safety

Common Sotyktu side effects can include upper respiratory tract infections, sore throat, headaches, acne, mouth ulcers, and cold sores. Some people report stomach discomfort or cough. Skin infections such as folliculitis can occur.

Serious risks are less common but can include serious infections, reactivation of tuberculosis, shingles, and certain malignancies. Increases in liver enzymes or lipids may appear on blood tests. Stop the medicine and seek urgent care if you develop signs of severe infection, shortness of breath, chest pain, or allergic reactions like swelling of the face, lips, or tongue.

Your clinician can explain which symptoms require immediate attention and whether additional monitoring is appropriate for you.

Drug Interactions and Cautions

Avoid live vaccines during treatment and shortly before starting. Tell your clinician about all medicines and supplements, including over‑the‑counter products and herbal remedies. Combining with other potent immunosuppressants may raise infection risk.

Certain strong enzyme inducers may lower exposure and reduce effectiveness; consult the Sotyktu label for specific agents and guidance. Do not initiate during an active serious infection, and screen for tuberculosis where indicated. If you have chronic liver disease, discuss risks and monitoring before starting.

What to Expect Over Time

Response varies. Some people may notice gradual improvement in plaques with steady daily use. Your clinician may evaluate your skin and symptoms after a period on therapy and adjust your care plan if needed. Keep taking the tablet as prescribed unless your prescriber tells you to stop.

Healthy routines help. Use a gentle cleanser, moisturize regularly, and follow any topical regimen your clinician recommends. Report new or worsening infections, and keep scheduled lab checks if they are ordered.

Compare With Alternatives

Two approved options commonly considered for adults with plaque psoriasis include:

• Otezla — an oral PDE4 inhibitor taken twice daily. It has a different mechanism and side effect profile. It may be chosen for patients seeking an oral non‑immunosuppressive option based on clinician judgment.
• Taltz — a subcutaneous IL‑17A inhibitor given by injection on a set schedule. It is a biologic and can be considered when an injectable approach is appropriate.

Your prescriber can help you decide among oral and injectable choices after reviewing your history and treatment goals.

Pricing and Access

Transparent access matters. We display current options so you can review the Deucravacitinib price and compare to typical U.S. cash‑pay. Orders are filled by licensed partners and Canada sourcing is shown where applicable. Fulfilment Ships from Canada to US. We use encrypted checkout to protect your information.

Savings CTA: See how Canadian pricing may lower your out‑of‑pocket costs versus typical retail. Pricing CTA: Check availability and current pricing before you place your order.

Category browsing can also help you compare options across Dermatology or explore therapies within Plaque Psoriasis.

Availability and Substitutions

Supply can vary. If this item is temporarily unavailable, your prescriber may recommend an alternative systemic therapy or a bridging plan until stock returns. We cannot guarantee restock dates, but our team can help you review comparable options your clinician has approved.

Patient Suitability and Cost-Saving Tips

This therapy suits adults who need systemic management of plaque psoriasis and prefer a once‑daily oral option. It may not suit those with severe hepatic impairment, active serious infections, or uncontrolled chronic infections. People with a history of recurrent shingles or tuberculosis need individualized risk discussion and screening.

Cost‑saving ideas include asking your clinician about multi‑month prescriptions to reduce per‑fill fees, setting refill reminders so you order before you run low, and combining eligible items in one shipment when practical. If you are paying without insurance, compare Canadian pricing with your local quotes to understand potential savings. Always follow your prescriber’s directions.

Questions to Ask Your Clinician

• Is an oral TYK2 inhibitor appropriate for my psoriasis severity?
• How do my other conditions affect the safety profile?
• What labs or screening do I need before and during therapy?
• Which vaccines should I update before starting?
• How should I handle minor infections while on treatment?
• What signs mean I should stop and call you right away?
• How long should we wait before assessing my response?

Authoritative Sources

Ready when your clinician has prescribed it? Order online for prompt, express shipping with temperature-controlled handling when required.

Disclaimer: This page is informational and does not replace professional medical advice. Always follow your prescriber’s guidance and the official labeling.