Amilzide® Tablets for Hypertension and Edema

Amilzide is a prescription water pill used to treat high blood pressure and swelling from fluid retention. It combines two diuretics that help your body remove extra salt and water while conserving potassium. We offer convenient US delivery from Canada, and many patients compare options when paying without insurance.

This page explains how the medicine works, who it may suit, common safety points, and practical tips for use and travel. It also covers strengths, interactions, storage, and ways you can manage refills and costs on BorderFreeHealth.

What Amilzide Is and How It Works

Amilzide® contains amiloride (a potassium-sparing diuretic) and hydrochlorothiazide (a thiazide diuretic). Together, they help lower blood pressure and reduce edema by increasing urine output. The combination is designed to reduce potassium loss seen with thiazides while maintaining blood-pressure control.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

You may see listings for Amilzide generic online. The active ingredients are amiloride and hydrochlorothiazide, which work by decreasing fluid volume and relaxing peripheral vessels over time. This medicine is taken by mouth and is generally used once daily, often in the morning.

Clinicians monitor electrolytes during therapy, especially potassium, sodium, and kidney function. The treatment may be used alone or with other blood-pressure therapies if additional control is needed.

Who It’s For

This combination is used in adults for hypertension and for edema due to heart, liver, or kidney conditions when a diuretic is indicated and potassium conservation is desired. It may be considered when low potassium occurred with a thiazide alone, or when there is a higher risk of hypokalemia.

People who should avoid this medicine include those with high potassium, severe kidney problems, inability to pass urine, or known allergy to amiloride, hydrochlorothiazide, or sulfonamide-derived drugs. Concomitant potassium supplements, salt substitutes containing potassium, or other potassium-sparing agents may raise potassium too high. Some markets label generics as Apo-Amilzide tablets, but suitability still depends on your clinical profile.

Use caution if you have gout, diabetes, lupus, liver disease, or a history of severe skin reactions to similar medicines. Sun sensitivity may increase; protective clothing and sunscreen are recommended.

Dosage and Usage

Follow your prescriber’s instructions and the official label. This medicine is typically taken once daily with food or milk to reduce stomach upset. Morning dosing may help limit nighttime urination. Swallow tablets with water and try to take the dose at the same time each day.

Do not change your dose without medical advice. Your healthcare professional may order periodic blood tests to check electrolytes and kidney function. Report muscle weakness, palpitations, or significant dizziness. Alcohol may enhance dizziness or lightheadedness, especially when starting therapy or increasing dose.

If you also take cholestyramine or colestipol, your prescriber may advise separating doses to avoid absorption issues. Defer to the approved product monograph if you are uncertain about timing with other medicines.

Strengths and Forms

Tablets are commonly available as a fixed-dose combination. In some regions this is referenced as Apo-Amilzide 5/50 mg. Availability can vary by market and manufacturer.

Typical presentation: 5 mg amiloride with 50 mg hydrochlorothiazide in a scored tablet. Check your dispensed package for exact markings and supplier details.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is almost time for the next dose. If it is close to the next scheduled time, skip the missed dose. Do not double up. To reduce sleep interruption, many people avoid late evening doses.

Storage and Travel Basics

Store tablets at room temperature, away from excess moisture, heat, and direct light. Keep the container closed tightly and out of reach of children and pets. Do not store in a bathroom where humidity fluctuates.

When traveling, keep medicine in original labeled packaging in your carry-on. Bring a copy of your prescription or a recent medication list. For longer trips, pack a small buffer supply as advised by your prescriber. If connecting across climates, a simple pill case inside your hand luggage usually protects tablets from temperature swings. As a general safeguard, we support encrypted checkout and clear order records for your travel documentation.

Benefits

This therapy can support blood-pressure reduction while conserving potassium compared with a thiazide alone. It can also help reduce swelling in conditions where a diuretic is appropriate. Once-daily dosing is convenient. Many people find the single-tablet approach simpler than taking two separate diuretics.

Because the combination is established in guidelines and labeling, clinicians can adjust other medicines around it. Routine labs help maintain safety while you continue lifestyle measures recommended for heart and kidney health.

Side Effects and Safety

• Increased urination
• Dizziness or lightheadedness
• Headache
• Nausea or stomach upset
• Muscle cramps or fatigue
• Rash or photosensitivity

Serious but less common risks include high potassium with heart rhythm changes, severe dehydration, low sodium, kidney issues, gout flare, or new eye pain suggesting angle-closure. Allergic reactions can occur. Seek urgent help for chest pain, fainting, severe weakness, or swelling of the face, lips, or tongue. The risk of low blood sugar may rise when used with insulin or sulfonylureas; clinicians often monitor closely in diabetes.

Drug Interactions and Cautions

Tell your prescriber about all medicines, vitamins, and supplements. Potassium supplements, potassium-sparing agents (for example, spironolactone), ACE inhibitors, ARBs, aliskiren, or salt substitutes may raise potassium. NSAIDs can blunt the diuretic effect and impact kidneys. Lithium levels can rise; monitoring is usually required if used together.

Other interactions may include digoxin, corticosteroids, amphotericin B, cholestyramine or colestipol, and certain diabetes medicines. Alcohol can increase dizziness. Your prescriber may adjust monitoring or suggest timing changes to minimize interactions.

What to Expect Over Time

Blood pressure effects may build gradually with steady use. Swelling from fluid retention can improve as the diuretic effect stabilizes. Your clinician may encourage home blood pressure checks and periodic labs to track response. If goals are not reached, therapy may be adjusted or combined with other classes.

Staying hydrated appropriately, moderating sodium intake, and consistent daily dosing can support effectiveness. Contact your healthcare professional if symptoms change or side effects persist.

Compare With Alternatives

Other options for blood-pressure control include single-pill combinations with different mechanisms. Some people may use an ACE inhibitor plus a thiazide, or a calcium-channel blocker when a diuretic is not suitable. Two medicines we carry that are often considered in similar care pathways are Lisinopril Hctz Type Z and Nifedipine Xr. Your prescriber can advise which class best fits your history and lab results.

Pricing and Access

You can review Cardiovascular options and see Canadian pricing alongside US delivery details. We offer transparent information so you can compare choices and talk with your prescriber. For cash-pay shoppers, you can evaluate your cash price and explore ways to bundle refills.

Orders are dispensed by licensed partners and Hypertension information on our site can help you prepare questions for your visit. The product Canada origin is shown when available, and items typically ship through our partner network. Ships from Canada to US fulfilment helps patients access therapies when local supply is limited. If you are searching for coupons, see our current Promotions.

Availability and Substitutions

Supply can vary. If a specific pack is unavailable, a prescriber may recommend a therapeutically equivalent generic, or an alternative diuretic plan. Label directions and safety monitoring remain the same regardless of brand supplier. We will contact you if your prescriber needs to approve a substitution.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults who need a diuretic and potassium conservation, especially after low potassium occurred with a thiazide alone. It may not suit those with high potassium, advanced kidney disease, or allergy to either component. People who pay out of pocket sometimes consider multi-month fills to reduce per-fill fees.

Ask about 60- or 90-day supplies if appropriate for your plan and monitoring schedule. Set refill reminders so you do not run out. Keep a copy of your prescription for travel and pharmacy coordination. For education on kidney health, see our article on CKD Treatment Approaches.

Questions to Ask Your Clinician

• Is a potassium-sparing diuretic appropriate for my history?
• How often should my electrolytes and kidneys be checked?
• What blood-pressure range should I target at home?
• Which medicines or supplements should I avoid?
• What signs of high or low potassium should I watch for?
• Could lifestyle changes allow a lower total diuretic dose?

Authoritative Sources

FDA DailyMed

Health Canada DPD

Captopril Uses and Bystolic Alternatives provide broader context for cardiovascular care.

Ready to proceed? You can order through BorderFreeHealth with prompt, express shipping and US shipping from Canada. This information is not a substitute for professional medical advice; always follow your prescriber’s guidance and the approved label.