Atropine Sulfate Injection

Atropine Sulfate is an anticholinergic agent used to treat bradycardia (slow heart rate), reduce saliva and secretions during surgery, and serve as an antidote for certain poisonings (e.g., organophosphates or nerve agents). It works by blocking the action of acetylcholine on muscarinic receptors, helping to increase heart rate and decrease bodily secretions. This pre-filled syringe formulation is designed for rapid and accurate administration in emergency or surgical settings.

Benefits

• Quickly increases heart rate in bradycardia or cardiac arrest
• Reduces saliva and respiratory secretions before anaesthesia
• Acts as a life-saving antidote for organophosphate and nerve agent poisoning
• Fast-acting injectable form for emergency use
• Convenient pre-filled syringe allows for accurate dosing

Dosage

• Bradycardia (adult): 0.5 mg IV every 3–5 minutes as needed; maximum total dose 3 mg
• Bradycardia (paediatric): 0.02 mg/kg IV; minimum dose 0.1 mg, maximum single dose varies by weight
• Pre-anaesthesia secretion reduction: 0.4–0.6 mg IV/IM/SC 30–60 minutes before surgery
• Poisoning (organophosphate/nerve agent): Initial dose 1–2 mg IV; may repeat every 5–10 minutes until muscarinic symptoms are controlled
• Dosage must be adjusted based on age, weight, and clinical situation
• Administration must be done by trained healthcare professionals

Warnings and Precautions

• Use with caution in patients with glaucoma, urinary retention, or obstructive gastrointestinal conditions
• May cause or worsen tachycardia (fast heart rate)
• Can cause central nervous system effects such as confusion or restlessness, especially in the elderly
• Not recommended for chronic use; intended for acute/emergency situations
• May interact with other anticholinergic or heart-related medications
• In poisoning cases, large or repeated doses may be required under close monitoring

Usage Instructions

• For intravenous (IV), intramuscular (IM), or subcutaneous (SC) injection
• Administer only under medical supervision
• Pre-filled syringes are for single-use only
• Discard any unused portion after opening
• Do not use if solution is discoloured or contains particles

Storage Information

• Store at controlled room temperature between 15°C and 30°C (59°F and 86°F)
• Protect from light
• Do not freeze
• Keep in original packaging until use
• Keep out of reach of children

Common Side Effects

• Dry mouth
• Blurred vision or dilated pupils
• Urinary retention
• Constipation
• Increased heart rate
• Confusion or agitation (especially in higher doses or elderly patients)
• More serious effects may include arrhythmias, respiratory distress, or severe allergic reactions