Braftovi® Capsules for BRAF-Mutant Melanoma and mCRC

Braftovi is an oral targeted therapy used in certain cancers with BRAF V600 mutations. It is taken as capsules, often combined with other medicines based on the condition. This page explains how it works, who may benefit, dosing basics, and safe use so you can make informed choices.

What Braftovi Is and How It Works

Braftovi® is the brand name for encorafenib, a BRAF kinase inhibitor. It helps block abnormal signaling in tumors with BRAF V600 mutations. For melanoma, it is used with a MEK inhibitor. For colorectal cancer, it is used with an EGFR inhibitor. Many patients look for US shipping from Canada and wonder about Braftovi price without insurance; we outline access options below. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Mechanistically, Braftovi inhibits mutated BRAF to reduce MAPK pathway signaling. This can slow tumor growth. When combined with other agents, the treatment targets multiple steps in the pathway. If you see references to Braftovi mechanism of action, they describe this pathway effect in line with the product label.

Because response and tolerability vary, your clinician will select combinations and monitor you. Use this information as a guide and rely on the official labeling for complete directions.

Who It’s For

This medicine is indicated for adults with unresectable or metastatic melanoma harboring BRAF V600E or V600K mutations, in combination with a MEK inhibitor. It is also indicated for adults with BRAF V600E-mutant metastatic colorectal cancer, in combination with an EGFR inhibitor, typically after prior therapy.

Use is limited to tumors confirmed to have an appropriate BRAF mutation. It is not for wild-type BRAF tumors. People with significant cardiac, hepatic, or ocular conditions may require closer monitoring or may not be candidates. Encorafenib Pfizer references relate to manufacturer information rather than suitability. Always review the official label and consult your healthcare professional.

Dosage and Usage

Your prescriber determines the schedule based on indication and combination partner. Typical label-directed regimens include:

• Melanoma: Encorafenib 450 mg by mouth once daily with a MEK inhibitor (binimetinib) twice daily.
• Metastatic colorectal cancer: Encorafenib 300 mg by mouth once daily with an EGFR inhibitor (cetuximab).

Swallow capsules whole with water. Take with or without food, at about the same time each day. If vomiting occurs after a dose, do not take an extra dose. Follow dose holds or reductions if your prescriber advises them for side effects.

If you see mention of Braftovi 75 mg dose online, that refers to capsule strength, not the daily total; the total daily amount comes from a combination of capsules per schedule above. Always follow the official labeling and your clinician’s directions.

Strengths and Forms

Encorafenib is supplied as hard gelatin capsules in commonly available strengths:

• 50 mg capsules
• 75 mg capsules

Availability may vary by pharmacy and country. Listings may mention Encorafenib 75mg capsules to indicate the higher capsule size often used to reach the daily amount with fewer capsules.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember unless it is close to the time of your next scheduled dose. If it is near the next dose, skip the missed dose and resume your usual schedule. Do not take two doses at once. If you vomit after taking a dose, do not retake it; wait until the next scheduled time. When uncertain, defer to the official label or contact your prescriber’s office for instructions.

Storage and Travel Basics

Store capsules at room temperature in the original container, tightly closed, and protected from moisture. Keep out of reach of children and pets. Do not use if the seal is broken or capsules are damaged.

When traveling, keep this medicine in your carry-on, along with a copy of your prescription. Use a small pill organizer only if it preserves dryness and labeling. Avoid excessive heat, freezing, or prolonged sun exposure. If your trip involves time zone changes, keep daily dosing intervals consistent. As with any oncology therapy, bring contact details for your cancer care team.

Benefits

Targeted therapies like this treatment may simplify daily routines compared with clinic-based infusions. Once-daily dosing can support adherence. Using a BRAF inhibitor with complementary agents may address resistance pathways. Many patients appreciate oral administration at home, while remaining connected to their oncology team for labs, skin checks, and imaging. Mentions of Braftovi encorafenib 75mg typically reflect formulation details used to achieve label-recommended amounts.

Side Effects and Safety

Common side effects can include fatigue, nausea, diarrhea, abdominal discomfort, joint or muscle pain, rash, dry skin, and hair changes. Photosensitivity and redness can occur, so use protective clothing and broad-spectrum sunscreen as recommended by your care team.

• Skin changes: rashes, acneiform eruptions, or dryness
• Gastrointestinal: nausea, vomiting, diarrhea, or abdominal pain
• Musculoskeletal: joint pain, muscle aches
• General: fatigue, headache

Serious risks can include new skin cancers, bleeding, liver effects, eye problems including retinal issues, QT prolongation, and embryo-fetal toxicity. Combination partners add their own safety profiles, such as ocular effects with MEK inhibitors or rash with EGFR inhibitors. Seek urgent care for vision changes, chest pain, signs of severe bleeding, or severe skin reactions. Your healthcare professional may order periodic labs and skin examinations.

Drug Interactions and Cautions

Encorafenib is metabolized primarily by CYP3A4. Strong CYP3A4 inhibitors can raise levels, and strong inducers can lower exposure. Examples include certain antifungals, macrolide antibiotics, some anti-seizure medicines, rifampin, and St. John’s wort. Avoid grapefruit products. Use caution with other drugs that prolong the QT interval. Tell your prescriber about all medicines, vitamins, and herbal products you use.

People with liver impairment may require adjustments per label guidance. Effective contraception is recommended during treatment and for a period after the last dose, per the official label.

What to Expect Over Time

Your team will track response with exams, imaging, and lab tests. Skin checks are common during and after treatment. Some side effects may improve with dose holds or supportive care. Results vary by cancer type, mutation status, prior therapy, and combination partner. Keep a dosing diary, report new symptoms early, and bring all medicines to visits so your clinician can review for interactions.

Compare With Alternatives

Therapy is individualized. For BRAF-mutant melanoma, MEK inhibitor combinations such as Mekinist with a BRAF inhibitor may be considered in certain settings. For previously treated metastatic colorectal cancer, multi-target oral options like Stivarga can be used in different clinical scenarios. Discuss goals, prior treatments, and mutation results with your oncology team before changing therapy.

Pricing and Access

We list transparent options so you can compare Braftovi price and review coverage discussions with your care team. Our team highlights Canadian pricing and helps coordinate US delivery from Canada when you submit your prescription. If you are comparing Encorafenib price across sources, align capsule strengths and total daily amounts for an apples-to-apples view.

Ask about pharmacy coordination through your clinic. If you are looking for savings, you can review current promotions on our site’s Promotions page. Checkout uses encrypted processes to protect your information.

Availability and Substitutions

Supply can vary by strength and partner pharmacy. If a specific strength is unavailable, your prescriber may recommend another strength combination to reach the prescribed total or a clinically appropriate alternative. Patients seeking to Order Braftovi online should upload a valid prescription so our team can verify details with your prescriber before dispensing.

Patient Suitability and Cost-Saving Tips

Good candidates typically have the required BRAF mutation and can adhere to daily dosing and monitoring. Those with significant heart rhythm concerns, active ocular disease, or moderate to severe liver impairment may need tailored plans or different options, per label guidance.

• Multi-month fills: reduce refill trips and help maintain continuity.
• Calendar reminders: support steady, same-time daily dosing.
• Travel planning: pack extra doses and documentation.
• Coordination: align refills with lab and imaging schedules.

Patients comparing options for Encorafenib self pay can ask their prescriber about capsule combinations that minimize waste. Discuss financial navigation resources through your clinic and confirm any monitoring costs in advance to avoid surprises.

Questions to Ask Your Clinician

• Is my tumor confirmed to have a BRAF V600 mutation?
• Which combination partner is recommended for my situation and why?
• How will we monitor for skin, heart, liver, and eye side effects?
• What signs mean I should call the clinic right away?
• How might other medicines or supplements interact with this therapy?
• If I need a dose hold, how will we restart safely?
• What is the plan if my disease progresses on this regimen?

Authoritative Sources

Manufacturer: BRAFTOVI patient site

FDA Prescribing Information

Health Canada Drug Product Database

Related Reading and Categories

For condition-focused guidance, explore our Melanoma and Colorectal Cancer pages. You can also browse Cancer Medicines or see items with Canada Origin. Learn more in our article Braftovi Cancer Therapy and our overview Colorectal Cancer Overview. For screening context, see Screening Awareness.

Ready to continue? You can upload your prescription and place your order with prompt, express shipping. This content is informational and does not replace the official label or your clinician’s advice.