Cabometyx® Tablets for Kidney Cancer

Cabometyx is a prescription tablet for certain advanced cancers. It is used mainly for kidney cancer, and in some cases liver or thyroid cancer. This page explains how it works, key safety points, and how you can order with US delivery from Canada, even if you are paying without insurance.

What Cabometyx Is and How It Works

Cabometyx® contains cabozantinib, a targeted cancer therapy called a tyrosine kinase inhibitor. It blocks multiple pathways, including MET, VEGFR, and AXL, which can help slow tumor growth and spread. The label describes the Cabozantinib mechanism of action as multi-kinase inhibition affecting tumor cells and tumor blood vessels.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine is approved for adults with advanced renal cell carcinoma. It is also used for hepatocellular carcinoma after certain prior treatments, and for some differentiated thyroid cancers that no longer respond to radioactive iodine. The tablets are not the same as cabozantinib capsules; they are not interchangeable.

You take this treatment by mouth, usually once daily, on an empty stomach. Swallow tablets whole with water. Do not crush or chew them. Your clinician will determine the most appropriate plan based on your diagnosis and prior therapies.

Who It’s For

This treatment is for adults with advanced kidney cancer. Some people may receive it alone, and others may receive it with an immunotherapy. It can also be used for liver cancer after prior therapy, and for certain radioiodine-refractory thyroid cancers.

If your condition involves the kidneys, you can explore our Kidney Cancer options. For liver disease, see Liver Cancer. For thyroid disease, review Thyroid Cancer.

People who should avoid this medicine include those with severe liver problems, certain bleeding risks, or recent serious wounds or surgery, per label guidance. It may harm an unborn baby; effective contraception is recommended during therapy and for a period after the final dose. Do not breastfeed during therapy and for a time after the last dose as advised by the label.

Dosage and Usage

Cabozantinib dosing follows the approved label for each indication. Many adults take one dose by mouth each day, without food. When given with certain immunotherapy agents, the daily amount is often lower than monotherapy. Your prescriber will choose a plan, and may adjust for side effects or liver function.

Take it on an empty stomach. Avoid food for at least 1 hour before and 2 hours after each dose. Avoid grapefruit products, which can change cabozantinib levels in the body. Do not replace a dose if you vomit; take the next dose at the usual time. Your care team may pause treatment for planned surgery and restart after adequate wound healing.

Some indications commonly use 60 mg once daily, while combination regimens may use less. Always follow your clinician’s instructions and the official label.

Strengths and Forms

Tablets are film-coated and color-coded by strength. Availability can vary based on stock and market authorization. Your clinician will select a strength that matches your treatment plan.

• Cabometyx tablets 20 mg
• 40 mg tablet
• 60 mg tablet

Not all strengths may be available at every partner pharmacy. Your prescriber may adjust the dose over time for safety and tolerability.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember unless it is close to the next scheduled dose. When it is almost time for your next dose, skip the missed dose. Do not take two doses at once. If you vomit after a dose, do not take an extra dose; take the next dose at the regular time. Keep your daily schedule consistent to support steady exposure.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from excess heat and moisture. Keep the bottle tightly closed and out of reach of children and pets. Do not store in a bathroom. When traveling, keep the medicine in the original labeled container, and carry a copy of your prescription. Use carry-on baggage to protect the tablets from loss or extreme temperatures. If your itinerary crosses time zones, keep the dosing interval roughly consistent and ask your clinician for help planning a schedule.

Benefits

This therapy can slow disease progression in approved indications. It may shrink some tumors or keep them from growing, depending on the cancer type and prior treatments. It is taken by mouth, which can be more convenient than some clinic-administered therapies. Many people use it as a single-agent option, and some use it alongside an immunotherapy, based on current approvals.

To learn more about evidence and uses, see our overview in Treatment Benefits. For a broader view of oncology options, browse our Cancer category.

Side Effects and Safety

• Diarrhea or constipation
• Tiredness and weakness
• Nausea or vomiting
• Decreased appetite and weight loss
• High blood pressure
• Mouth sores or sore throat
• Hoarseness
• Hand–foot skin reaction
• Abdominal pain

Cabozantinib side effects can also include serious risks. These may involve bleeding, blood clots, gastrointestinal perforations or fistulas, severe hypertension, wound healing problems, or rare brain events like PRES. Dental issues such as jaw bone problems have been reported with some anti-angiogenic therapies; tell your clinician if you have dental concerns. Seek urgent care for severe headache, chest pain, breathing trouble, heavy bleeding, or sudden neurologic changes. Regular lab monitoring may be needed for liver, kidney, and thyroid function.

Immunotherapy combinations are common in kidney cancer. For background on one checkpoint inhibitor used in this area, see Bavencio Avelumab.

Drug Interactions and Cautions

Strong CYP3A4 inhibitors and inducers can raise or lower cabozantinib exposure. Your prescriber may switch interacting medicines or change the plan. Avoid grapefruit and grapefruit juice. Use caution when combining with drugs that increase bleeding risk, such as anticoagulants or antiplatelets, unless your clinician advises otherwise. People with moderate liver impairment may need a lower dose; those with severe impairment should generally not use this medicine. Tell your team about upcoming dental work or surgery so timing can be managed to reduce wound-healing risks.

What to Expect Over Time

Some side effects appear early and can be manageable with supportive care or dose changes. Others may emerge after weeks of therapy. Your clinician will monitor your response and tolerability, and may adjust treatment if needed. Many people do not feel immediate changes in symptoms. Imaging and labs typically guide assessment over time. Keep a simple log of doses and any symptoms to help your care team make decisions.

Compare With Alternatives

Other approved oral options exist for renal and liver cancers. Axitinib is used for kidney cancer in several settings and may be combined with immunotherapy; see Inlyta. Regorafenib is used after prior treatments in certain cancers, including liver cancer; review Stivarga. Your prescriber can help determine whether a tyrosine kinase inhibitor or an immuno-oncology approach fits your history and goals.

Pricing and Access

We offer Canadian-sourced options with US shipping from Canada. Many patients look up Cabozantinib price to compare their cash-pay options. Your final amount depends on strength, quantity, and your prescriber’s directions. You can check currently available strengths on this page and request a quote for your specific plan.

If you are exploring discounts, see our Promotions. For transparency on origin, tap the attribute tag for Canada on relevant items. We use encrypted checkout to protect your information during payment. For background reading on targeted oncology therapies, see Afinitor Uses.

Availability and Substitutions

Supply may vary by strength and prescriber demand. Generic cabozantinib tablets availability differs by market; your clinician will decide if a substitution is appropriate. If the requested strength is unavailable, your prescriber may recommend an alternative therapy from the same class or a different class. We cannot comment on restock dates, but we can help coordinate with your prescriber if an alternative is needed.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with advanced kidney cancer who can take an oral regimen and follow lab monitoring. It may also be appropriate for some people with liver or thyroid cancers after prior therapies. People with uncontrolled blood pressure, recent major surgery, significant bleeding risks, or severe liver disease may not be candidates.

To help manage costs, ask your clinician if longer refill intervals fit your plan. Larger fills can reduce separate service fees and limit pharmacy trips. Set calendar reminders so you do not miss refills while traveling. Keep all lab and blood pressure checks on schedule, since early side effect management can reduce interruptions that jeopardize therapy continuity.

Questions to Ask Your Clinician

• Is this treatment my best first option or a later-line choice?
• Should I use it alone or with an immunotherapy?
• How will we monitor safety and response over time?
• What symptoms mean I should call your office right away?
• Are there medicines, foods, or supplements I must avoid?
• How should we plan around dental work or surgery?
• What is the plan if side effects require a pause or change?
• How long might I continue treatment if it is working?

Authoritative Sources

FDA DailyMed: CabozantinibHealth Canada DPD: Cabozantinib TabletsManufacturer: Ipsen Product Page

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