Lupin-Tiotropium

Uses of Lupin-Tiotropium

Tiotropium bromide inhalation powder is an anticholinergic indicated for the long-term, once-daily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), and for reducing COPD exacerbations.

Precautions and Warnings

Immediate Hypersensitivity Reactions: Immediate hypersensitivity reactions, including urticaria, angioedema (including swelling of the lips, tongue, or throat), rash, bronchospasm, anaphylaxis, or itching, may occur after administration of tiotropium bromide inhalation powder. If such a reaction occurs, therapy with tiotropium bromide inhalation powder should be stopped at once and alternative treatments should be considered. Given the similar structural formula of atropine to tiotropium, patients with a history of hypersensitivity reactions to atropine or its derivatives should be closely monitored for similar hypersensitivity reactions to tiotropium bromide inhalation powder. In addition, tiotropium bromide inhalation powder should be used with caution in patients with severe hypersensitivity to milk proteins.

Paradoxical Bronchospasm: Inhaled medicines, including tiotropium bromide inhalation powder, may cause paradoxical bronchospasm. If this occurs, it should be treated immediately with an inhaled short- acting beta2-agonist such as albuterol. Treatment with tiotropium bromide inhalation powder should be stopped and other treatments considered.

Worsening of Narrow-Angle Glaucoma: Tiotropium bromide inhalation powder should be used with caution in patients with narrow-angle glaucoma. Prescribers and patients should be alert for signs and symptoms of acute narrow-angle glaucoma (e.g., eye pain or discomfort, blurred vision, visual halos or colored images in association with red eyes from conjunctival congestion and corneal edema). Instruct patients to consult a physician immediately should any of these signs or symptoms develop.

 Worsening of Urinary Retention: Tiotropium bromide inhalation powder should be used with caution in patients with urinary retention. Prescribers and patients should be alert for signs and symptoms of urinary retention (e.g., difficulty passing urine, painful urination), especially in patients with prostatic hyperplasia or bladder-neck obstruction. Instruct patients to consult a physician immediately should any of these signs or symptoms develop.

Side Effects

Common Side Effects:

• Arm, back, or jaw pain
• chest pain or discomfort
• chest tightness or heaviness
• fast or irregular heartbeat
• nausea
• sweating
• trouble breathing