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Mesacol® OD Tablets for Ulcerative Colitis
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Mesacol OD is a delayed-release mesalamine tablet used for ulcerative colitis. It helps reduce inflammation in the colon and supports remission maintenance. This page explains how the treatment works, who it may suit, and how you can manage access and costs, including Mesacol OD price without insurance.
What Mesacol Is and How It Works
This medicine is an oral 5‑aminosalicylic acid therapy for mild to moderate disease, with US delivery from Canada. Mesacol® OD uses a delayed-release matrix designed to deliver mesalamine throughout the colon. It acts locally in the intestinal lining, reducing inflammatory mediators that contribute to symptoms like urgency, bleeding, and abdominal pain. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.
It is typically used for induction of remission and for maintenance in appropriate patients. The tablet should release drug in the colon rather than the stomach, which is why swallowing it whole matters. For the condition overview and management basics, see Ulcerative Colitis.
Who It’s For
This treatment is intended for adults diagnosed with ulcerative colitis who need an oral aminosalicylate. Some adolescents may also use mesalamine at a prescriber’s discretion. It is not for patients with known hypersensitivity to salicylates or mesalamine. People with significant kidney or liver disease, or a history of myocarditis, pericarditis, or pancreatitis, should discuss risks carefully with a clinician.
If you are exploring other digestive therapies, browse our Gastrointestinal options for context and related products.
Dosage and Usage
Follow your prescriber’s directions exactly and review the official label. Many patients take this medicine once daily with a meal. Swallow tablets whole; do not split, crush, or chew. Taking doses at the same time each day can support consistent symptom control. Drink water regularly during the day unless advised otherwise by your healthcare professional.
Do not change your regimen on your own. If symptoms persist or worsen, contact your prescriber. If switching from another mesalamine product, note that formulations and release profiles differ; rely on medical guidance for transitions. For educational comparisons across brands, you can read Asacol Vs Lialda and Asacol Vs Pentasa.
Strengths and Forms
The product is supplied as oral delayed-release tablets. Commonly referenced presentations include Mesalamine 1.2 g ER tablets. Availability, pack sizes, and manufacturers may vary by sourcing pharmacy.
Missed Dose and Timing
If you miss a dose, take it when you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at once. If repeated doses are missed, speak with your clinician to keep your plan on track.
Storage and Travel Basics
Store tablets at room temperature in a dry place, away from bathroom humidity. Keep the bottle tightly closed and out of reach of children and pets. Do not transfer doses into unlabeled containers. When traveling, keep this medicine in your hand luggage with a copy of your prescription and your prescriber’s contact details. Our partners use temperature-controlled handling when required, and your order arrives in discreet packaging.
Plan ahead for refills before trips and time zone changes. If monitoring supplies, a weekly check can prevent gaps. For background on other mesalamine products, see Delzicol Vs Asacol. Mesacol OD ships to US.
Benefits
As an oral 5‑ASA, this treatment can support remission induction and help maintain symptom control in mild to moderate disease. Once-daily dosing simplifies routines for many patients. Local action in the colon means limited systemic absorption compared with some other classes. This medicine may also be combined with rectal therapies during flares if a prescriber recommends that approach.
Side Effects and Safety
- Headache
- Nausea or vomiting
- Abdominal pain
- Diarrhea or gas
- Fatigue
- Rash or itching
Serious reactions are uncommon but can include kidney problems, liver issues, blood disorders, myocarditis or pericarditis, pancreatitis, severe skin reactions, or hypersensitivity. Stop the medicine and seek medical care right away if you develop chest pain, shortness of breath, dark urine, severe abdominal pain, unusual bleeding, or signs of allergy. Tell your prescriber about prior salicylate reactions or aspirin sensitivity.
Drug Interactions and Cautions
Tell your clinician about all medicines, vitamins, and herbs. Notable interactions can occur with azathioprine or 6‑mercaptopurine, which may increase the risk of blood cell changes; careful lab monitoring may be needed. Use caution with nephrotoxic agents and NSAIDs due to kidney risk. Some antacids or acid suppressors can alter gastrointestinal pH, which may affect release characteristics; your prescriber can advise on timing if needed. Report any history of kidney or liver disease before starting therapy.
What to Expect Over Time
Inflammation control is gradual. Some patients notice changes in urgency or bleeding as adherence continues, but individual responses vary. Keep taking the tablets exactly as directed even if symptoms improve. Periodic check-ins and lab monitoring help ensure the therapy stays appropriate. If you experience new or worsening symptoms, notify your healthcare professional promptly.
Compare With Alternatives
Other options may be considered depending on disease severity and location. For rectal involvement, topical steroids can be added; see Uceris® Rectal Foam. In certain cases, an oral controlled‑release steroid may be used short‑term for flares; see Budez® Cr 3mg India. Classic mesalamine capsules or conventional tablets are another avenue and may suit different dosing strategies under prescriber guidance.
Pricing and Access
Border Free Health lists current Canadian pricing with transparent details. You can review options, start your order, and upload your prescription online. US shipping from Canada is available to your address after your prescription is verified. For cost planning, see our article on Without Insurance Costs. Order Mesacol OD online. If you are searching for seasonal deals, you may check Promotions.
Availability and Substitutions
Supply can vary by manufacturer and country of origin. If a specific pack or brand is unavailable, your prescriber may recommend a therapeutically appropriate alternative. Some pharmacies source from India; you can explore items tagged by origin here: India. Mesacol OD generic equivalent may be dispensed if authorized and appropriate for your prescription.
Patient Suitability and Cost-Saving Tips
This therapy may suit adults with mild to moderate ulcerative colitis who benefit from a once‑daily 5‑ASA. It may not suit people with severe renal impairment, active liver disease, or salicylate allergy. Discuss pregnancy, breastfeeding, and plans for conception with your prescriber before starting. Keep routine labs as directed to monitor kidney function. Buy mesalamine 1.2 g.
To manage out‑of‑pocket costs, consider multi‑month fills when your prescriber agrees. Align refills with clinic visits so labs and authorizations stay current. Set phone reminders for daily dosing and reorders. Compare package sizes for the best overall pricing per day of therapy.
Questions to Ask Your Clinician
- Is a once‑daily mesalamine appropriate for my current disease activity?
- Should I combine oral therapy with a rectal formulation during flares?
- What lab tests and monitoring schedule do you recommend for kidney health?
- How long should I continue maintenance if I remain in remission?
- Which warning symptoms mean I should stop the medicine and call you?
- Could other conditions or medicines affect how this therapy works for me?
Authoritative Sources
Health Canada Drug Product Database
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What is Mesacol OD used for?
Mesacol OD is an extended-release form of mesalamine used to treat and prevent relapses in ulcerative colitis. It allows for once-daily dosing, improving patient adherence and providing continuous anti-inflammatory action throughout the colon.
How is Mesacol OD different from regular Mesacol?
The OD (once-daily) formulation is designed to release mesalamine gradually over time, offering consistent therapeutic levels. This makes it more convenient and potentially more effective in maintaining remission.
How should Mesacol OD be taken?
It should be taken once daily, preferably at the same time each day. The tablet should not be crushed or chewed, as this would interfere with its extended-release properties.
Are side effects similar to Mesacol?
Yes, side effects such as headache, nausea, and abdominal pain are similar to those of regular Mesacol. Monitoring kidney function is important during long-term therapy.
Can Mesacol OD be used during flare-ups?
Yes, it is effective during both active phases and maintenance of remission. Your doctor will determine the correct dosage based on disease severity and treatment goals.
What is the difference between OD tablets and other mesalamine forms?
OD tablets are designed for delayed release so the active ingredient reaches the colon over time. Other mesalamine products use different coatings or release technologies, and some require multiple daily doses. Because formulations are not interchangeable, your prescriber will choose a version that fits your disease location, dosing preference, and response history. Always follow the specific directions on your label.
How should I take this medicine to get the best effect?
Take it exactly as prescribed, usually at the same time each day and with food if directed. Swallow tablets whole to preserve the delayed‑release coating. Do not crush or chew. If you miss a dose, take it when you remember unless it is close to the next dose. Consistent routines, hydration, and regular follow‑ups can help support treatment goals.
Can I use it with probiotics, vitamins, or antacids?
Tell your healthcare professional about all supplements and over‑the‑counter products. Some antacids and acid suppressors may change stomach pH and could affect release characteristics in certain formulations. Interactions are also possible with other medicines, so your prescriber may advise timing adjustments. Keep a complete medication list and share it during visits to avoid conflicts.
What monitoring is typically needed with mesalamine therapy?
Clinicians often check kidney function before starting and periodically during treatment. You should also report any new chest pain, shortness of breath, severe abdominal pain, rash, or unusual bleeding. Monitoring frequency depends on your history, concurrent medicines, and overall health. Follow your clinician’s guidance and the official product label for testing intervals and safety warnings.
Is alcohol allowed while taking this therapy?
Alcohol can irritate the gastrointestinal tract and may worsen symptoms for some people with colitis. While there is no specific contraindication noted for all patients, moderation and caution are sensible. Discuss your drinking habits with your prescriber, especially if you have liver concerns or take other medicines that affect the liver or stomach lining.
What if symptoms flare while I am on maintenance dosing?
Flares can still occur. Contact your prescriber if bleeding, urgency, or pain increases. Your plan may need short‑term adjustments, such as adding a rectal therapy or reassessing your regimen. Do not change doses on your own. Keep notes on symptoms and triggers, as that information can help your clinician tailor your treatment strategy.
Can I take it during pregnancy or breastfeeding?
Many clinicians consider mesalamine when benefits outweigh risks, but decisions are individualized. Share pregnancy plans and breastfeeding status with your prescriber before starting or continuing therapy. They will review your history, disease control, and available safety data to select the most appropriate option and monitoring plan for you.
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