Prezcobix® Tablets for HIV-1

Prezcobix® is a prescription combination tablet for HIV-1. It pairs darunavir with cobicistat to help maintain therapeutic levels as part of a complete regimen. You can access options with US shipping from Canada, and this page explains access for Prezcobix without insurance.

What Prezcobix Is and How It Works

This medicine combines a protease inhibitor with a pharmacokinetic enhancer. Darunavir blocks the HIV-1 protease enzyme, which the virus needs to mature. Cobicistat slows the breakdown of darunavir, increasing blood levels so the treatment can work at a consistent level. Together, the pair is used with other antiretroviral medicines to build a complete regimen. That is what prezcobix used for in labeling and clinical practice.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Use must follow the official prescribing information. This therapy is not a cure. It can help reduce viral load and support immune function when taken exactly as directed and combined with other active agents.

Learn more about the condition in our overview of HIV and see related treatment options in Antivirals.

Who It’s For

This treatment is indicated, in combination with other antiretrovirals, for adults and adolescents who meet weight criteria and have HIV-1. It may be suitable for people initiating therapy or switching regimens when their virus is expected to be susceptible to the protease inhibitor. Those with known darunavir resistance-associated mutations may require different options.

Avoid use if you take certain interacting medicines that are contraindicated with strong CYP3A inhibitors. People with severe liver impairment should generally not use this product. Discuss sulfonamide allergy history with a prescriber, as darunavir contains a sulfonamide moiety. For childbearing potential, review reliable contraception because interactions may affect hormonal methods.

For plain-language background on other regimens, see our Biktarvy HIV Treatment guide.

Dosage and Usage

The standard schedule is one tablet taken once daily with food, together with other antiretroviral agents chosen by your prescriber. Swallow whole with a beverage. Taking it with a meal helps absorption and may reduce stomach upset. Do not take more than the recommended dose. If there is uncertainty about timing, defer to the official label and your healthcare professional.

Do not use with other products that contain cobicistat or ritonavir, or with any other darunavir-containing medicine. If your regimen includes tenofovir disoproxil fumarate, your prescriber may monitor kidney function more closely. Stay consistent with daily timing to maintain steady drug exposure. Keep a medication list with you, and coordinate all new prescriptions with your care team to avoid interactions.

Strengths and Forms

This product is supplied as film‑coated tablets. A commonly available presentation is darunavir cobicistat 800/150 mg tablets. Availability can vary by partner pharmacy and market. Packaging details and tablet appearance may differ by batch. Your dispensing label shows the exact strength and quantity supplied.

Missed Dose and Timing

If you miss a dose and remember within a reasonable window, take it with food as soon as you can. If it is close to the next scheduled dose, skip the missed dose and resume your normal schedule. Do not take two doses at once. If vomiting occurs shortly after a dose, guidance can vary; consult the official patient information or your prescriber for what to do in that situation.

Storage and Travel Basics

Store tablets at room temperature in the original container with the desiccant, and keep the cap closed. Protect from moisture and keep out of reach of children and pets. For travel, carry the labeled container in your hand luggage along with a copy of your prescription. Allow extra time at security checkpoints, and keep a small buffer supply in case of delays. If crossing time zones, pick a convenient local time and maintain once‑daily spacing.

Benefits

As part of a complete regimen, this protease inhibitor combination may help lower viral load and increase CD4 counts. Once‑daily dosing can be convenient for some patients. Food dosing may improve stomach comfort for individuals sensitive to medicines on an empty stomach. Using a pharmacokinetic booster supports consistent exposure, which can help maintain treatment effect when used as directed.

Side Effects and Safety

• Diarrhea or loose stools
• Nausea or vomiting
• Headache
• Rash
• Abdominal pain
• Tiredness

Serious risks can include severe skin reactions, liver problems, and allergic reactions. Kidney function changes can occur, and creatinine may rise from cobicistat’s effect on tubular secretion. Immune reconstitution syndrome has been reported with antiretroviral therapy. Seek urgent care for symptoms such as widespread rash, yellowing skin or eyes, dark urine, severe abdominal pain, or shortness of breath. Review the full safety profile in the official labeling before use.

Drug Interactions and Cautions

Because the booster is a strong CYP3A inhibitor, it has many clinically important interactions. Contraindicated examples include rifampin, carbamazepine, phenobarbital, phenytoin, St. John’s wort, triazolam, oral midazolam, lomitapide, and certain ergot derivatives. Lovastatin and simvastatin are contraindicated; other statins require caution and the lowest necessary dose. Certain antiarrhythmics, anticoagulants, anticonvulsants, and PDE‑5 inhibitors may require careful review.

Hormonal contraceptives containing ethinyl estradiol can be affected; use an effective alternative method. Tell your prescriber about all prescription, OTC, and herbal products. Do not start or stop any medicine without medical guidance while on this regimen.

What to Expect Over Time

With steady daily dosing, many patients see viral load decline as part of combination therapy. Your prescriber will assess lab results, adherence, and tolerability to guide ongoing care. If side effects occur, options may include supportive measures or adjusting companion agents. Keeping a daily routine, using a pill organizer, and aligning doses with meals can support consistent use. For broader education on screening and care, explore HIV Tests and community awareness such as HIV Testing Day.

Compare With Alternatives

Some patients may use an NNRTI‑based regimen such as Pifeltro® with companion agents, depending on their resistance profile and clinical goals. Others may use integrase inhibitor–based combinations. Your prescriber weighs drug interactions, prior therapy, and lab data to select a regimen. To browse similar classes, see our Antivirals section.

Pricing and Access

We display transparent options reflecting Canadian pharmacy networks, with US delivery from Canada. If you are comparing the Prezcobix price, review the product page for current figures and availability. For component‑based purchases, some patients also compare darunavir cobicistat price to understand their choices. Checkout uses encrypted checkout, and taxes or dispensing fees may vary by partner.

Looking for deals? See any current site offers on our Promotions page. For documentation of origin, see Canada.

Availability and Substitutions

Supply can vary. If an item is unavailable, a prescriber may recommend an alternative protease inhibitor–based regimen or a different class that fits your history. People sometimes compare options if they plan to buy darunavir cobicistat as separate components; your care team should guide that decision.

Patient Suitability and Cost-Saving Tips

This therapy may fit adults and adolescents meeting weight criteria with susceptible virus and without contraindicated interactions. It may not fit those with severe hepatic impairment or certain comedications. To reduce overall costs, consider multi‑month refills if your prescriber agrees. Use reminders or calendar alerts to stay on schedule. Keep your medication list current and bring it to appointments so your clinician can prevent unnecessary switches or duplicate therapies.

Questions to Ask Your Clinician

• Regimen fit: Is this combination appropriate for my resistance profile?
• Companion agents: Which other medicines should accompany this therapy?
• Interactions: Do any of my current drugs or supplements conflict?
• Monitoring plan: Which labs and follow‑up visits will I need?
• Side effects: What symptoms should prompt a call or visit?
• Family planning: What contraception or pregnancy precautions apply?
• Adherence support: What daily routine or tools do you recommend?

Authoritative Sources

FDA DailyMed

Health Canada DPD

Manufacturer Prescribing Information

Ready to get started? You can place your order and choose prompt, express shipping that Ships from Canada to US. This information is educational and not a substitute for medical advice from your healthcare professional.