Selegiline Tablets for Parkinson's Disease

This medicine is an MAO-B inhibitor used with levodopa for Parkinson’s disease. It helps reduce “wearing off” and supports steadier motor control. You can compare options and plan ordering details with US delivery from Canada, including typical costs for selegiline without insurance.

What Selegiline Is and How It Works

Selegiline is a selective monoamine oxidase type B inhibitor at standard oral doses. It helps slow the breakdown of dopamine in the brain. This action can smooth fluctuations when used with levodopa in Parkinson’s disease. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

At recommended doses, it generally maintains MAO-B selectivity, which limits dietary tyramine concerns. At higher exposures or certain interactions, selectivity can decrease. The treatment may increase dyskinesia in some patients when levodopa levels rise. Your clinician may monitor symptoms and adjust your overall regimen if needed. Some countries know this active ingredient by older names such as l-deprenyl or deprenyl, and products labeled as l deprenyl tablets represent the same molecule.

For broader context on related conditions and therapies, see our Neurology category and the Parkinsons Disease hub.

Who It’s For

This medicine is indicated as an adjunct to levodopa/carbidopa for Parkinson’s disease. It can help reduce off-time and improve daily function. People with hypersensitivity to components should avoid it. Those taking other monoamine oxidase inhibitors, meperidine, tramadol, methadone, or certain antidepressants should not combine them due to serious interaction risks. The oral form discussed here refers to selegiline hydrochloride tablets.

Caution is advised if you have severe liver disease, uncontrolled hypertension, or a history of mania or psychosis. Tell your clinician about all medicines, vitamins, and herbal products you take.

Dosage and Usage

Follow your prescription exactly. The typical labeled schedule for tablets is 5 mg twice daily, usually taken at breakfast and lunch, together with levodopa/carbidopa. Taking the second dose at lunchtime may help reduce insomnia. Do not exceed the prescribed daily amount. If your prescriber has chosen a different plan, follow their instructions. For reference, the tablet strength often dispensed is the selegiline 5 mg tablet.

Swallow tablets with water. You can take them with or without food. Try to take doses at consistent times each day. Do not split or crush unless your pharmacist confirms it is appropriate for your specific product. Avoid evening doses to reduce sleep disturbance.

If dose changes are considered, your prescriber will guide them based on response and tolerability. Self-adjusting is not recommended. For general info on care continuity, you may find Online Prescriptions helpful.

Strengths and Forms

Common tablet strengths include 5 mg and 10 mg. Availability can vary by manufacturer and country of origin. Names differ by market, and some regions reference brands historically associated with this ingredient, including Eldepryl 10 mg. Dissolving oral forms and transdermal systems exist for other labeled uses, but availability is product- and market-specific. Stock status may differ over time.

Missed Dose and Timing

If you miss a dose, take it when remembered unless it is close to the next dose. If it is near the next dose, skip the missed dose and resume your regular schedule. Do not double up. Keeping doses earlier in the day can help limit insomnia. Use a reminder on your phone or a pill organizer to maintain a steady routine.

Storage and Travel Basics

Store tablets at room temperature in the original container with the desiccant if provided. Protect from moisture and light. Keep out of reach of children and pets. Do not store in a bathroom cabinet where humidity is high. When traveling, keep the labeled prescription bottle in your carry-on and bring a copy of your prescription. If crossing borders, allow extra time for screening and keep medicines in original packaging.

Use child-resistant closures and secure storage at home. If your clinician changes your therapy, ask how to dispose of unused tablets safely according to local guidance.

Benefits

As an add-on to levodopa/carbidopa, this medicine may reduce off-time and smooth motor fluctuations. Earlier-in-the-day dosing can lessen sleep disruption for many patients. Tablet dosing offers a familiar route of administration and can simplify routines. The treatment is part of an established class with well-described labeling and interaction guidance.

Side Effects and Safety

• Common effects: nausea, dry mouth, dizziness
• Sleep issues: insomnia or vivid dreams
• Neurologic: headache, confusion, agitation
• Cardiovascular: orthostatic dizziness or changes in blood pressure
• Movement: increased dyskinesia when used with levodopa

Serious reactions can include hypertensive events with contraindicated drugs or excess tyramine exposure at higher systemic activity, and serotonin syndrome with interacting antidepressants or certain opioids. Hallucinations or behavioral changes may occur, particularly in older adults or those with underlying risk. Seek urgent care for severe headache, chest pain, palpitations, high fever, or sudden changes in mental status.

Drug Interactions and Cautions

Do not combine with other MAO inhibitors, or with meperidine, tramadol, methadone, linezolid, or methylene blue. Combining with SSRIs, SNRIs, tricyclics, or other serotonergic agents raises the risk of serotonin syndrome. Allow appropriate washout intervals when switching therapies as directed by a clinician.

Use caution with dextromethorphan, sympathomimetics, and many cold remedies. Review all over-the-counter products with your pharmacist. Alcohol may worsen dizziness or drowsiness. Tyramine-rich foods are generally less concerning at recommended oral doses, but follow your prescriber’s dietary advice. For background on SSRI risks, see Zoloft Side Effects.

What to Expect Over Time

Many people notice gradually steadier motor periods when the medicine is added to levodopa. Some may need adjustments to their overall regimen to balance benefits and dyskinesia. Sleep patterns can improve by keeping doses earlier in the day. If you experience new or worsening symptoms, contact your clinician promptly. Historical brand references such as Eldepryl 5 mg may appear on older resources; the active ingredient remains the same.

Adherence helps sustain benefits. Consider a weekly check-in to track off-time, sleep quality, and any side effects. Record changes you notice and share them at follow-up visits.

Compare With Alternatives

Rasagiline is another MAO-B inhibitor option. Some patients start with Azilect for once-daily dosing. Others adjust their levodopa regimen; your prescriber may consider combinations like Levodopa Carbidopa depending on goals and tolerability. Choice depends on clinical history and response.

Pricing and Access

You can review Canadian pricing with US shipping from Canada and compare fill options. Check today’s selegiline price and see how multi-bottle fills may lower per-unit costs. For patients paying cash, look at the estimated “selegiline out of pocket” and any available savings. We also reference “selegiline Canadian pricing” where applicable. If you use discount offers, see our current Promotions. Checkout is secured with encrypted processing.

If you need help estimating your total, contact support before you place an order. We’ll outline steps to upload your prescription and confirm details.

Availability and Substitutions

Supply can vary by manufacturer. If a specific tablet strength or pack size is unavailable, a prescriber may recommend a therapeutically appropriate alternative. We cannot guarantee restock dates. Your clinician or pharmacist can discuss equivalent options under the same class.

Patient Suitability and Cost-Saving Tips

This therapy suits adults with Parkinson’s disease who need adjunct support with levodopa. It may not be appropriate for those with contraindicated drug regimens or certain psychiatric histories. Always review your full medicine list with a clinician.

• Multi-month fills: fewer refills and potential savings
• Aligned refills: sync dates with levodopa renewals
• Travel-ready: keep documentation in your carry-on
• Reminders: set phone alerts for morning and noon dosing
• Follow-up: note off-time and side effects for visits

For broader brain health insights, see Brain Health. Country-of-origin details for stocked lots appear on product pages, including items sourced from Canada.

Questions to Ask Your Clinician

• Goals: which symptoms should improve with this add-on?
• Timing: how should I time doses with levodopa?
• Safety: which cold or cough products should I avoid?
• Interactions: what washout periods apply if I need an antidepressant?
• Sleep: how can I reduce insomnia risk with earlier dosing?
• Monitoring: which signs mean I should call promptly?

Authoritative Sources

FDA DailyMed: Selegiline Tablets

Health Canada Drug Product Database

FDA Labeling: Eldepryl (reference)

Ready to get started? Place your order with prompt, express shipping that Ships from Canada to US, with temperature-controlled handling when required. This content is for general information and does not replace your clinician’s guidance or the official label.