Januvia® Tablets for Type 2 Diabetes

Sitagliptin is a DPP-4 inhibitor taken by mouth to help manage type 2 diabetes. It supports better blood sugar control alongside diet and exercise. This page explains how it works, who it may suit, and how you can order with confidence.

What Januvia Is and How It Works

Januvia® contains sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases incretin activity to promote meal-time insulin release and to reduce glucagon when glucose is high. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing. For convenient access, this treatment Ships from Canada to US and can help if you pay without insurance. Sitagliptin tablets work as monotherapy or with other agents such as metformin or insulin when appropriate.

This medicine is taken once daily, with or without food. It does not replace lifestyle measures. You still need diet, activity, and regular follow-up. Learn more about the condition in our Type 2 Diabetes resource.

Who It’s For

This therapy is used to improve glycemic control in adults with type 2 diabetes mellitus as part of a comprehensive plan with diet and exercise. It is not for type 1 diabetes or diabetic ketoacidosis. People with a history of serious allergy to sitagliptin should not use it. Those with pancreatitis risk, kidney impairment, or blistering skin disorders should discuss suitability with a clinician. If you are pregnant or breastfeeding, your prescriber will weigh potential benefits and risks.

Dosage and Usage

Typical dosing follows the official label. Many adults take Sitagliptin 100 mg by mouth once daily. If you have reduced kidney function, prescribers may choose a lower strength. Do not change your dose without guidance. Take the tablet at roughly the same time each day. It can be taken with food or on an empty stomach. If used with insulin or a sulfonylurea, your clinician may monitor more closely for low blood sugar. Refer to the FDA or Health Canada label for complete dosing details.

Strengths and Forms

This treatment is available as film-coated oral tablets. Commonly published strengths include 25 mg, 50 mg, and 100 mg. Availability and manufacturers may vary over time. We carry multiple presentations to support prescriber-directed therapy.

• Sitagliptin 25 mg tablets
• 50 mg tablet option for dose adjustments
• 100 mg tablet for standard adult dosing when appropriate

Explore related options within our Diabetes Care category for accessories and glucose supplies.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. If it is close to your next scheduled dose, skip the missed one and resume your regular time. Do not take two doses at once.

Storage and Travel Basics

Store tablets at room temperature in the original container, protected from excess moisture and light. Keep out of reach of children and pets. When traveling, carry your medicine in your hand luggage, along with a copy of your prescription and a medication list. Use a daily reminder to help you take doses on time across time zones. Do not store tablets in a hot car or humid bathroom. If you have questions about documentation for air travel, your pharmacist can advise.

Benefits

This class may help lower A1C and fasting and post-meal glucose when taken consistently with diet and exercise. It is taken once daily, which can support adherence. When used alone, it has a low risk of hypoglycemia. It is generally weight neutral. It can be combined with metformin or insulin-based regimens when directed by a prescriber.

Side Effects and Safety

• Upper respiratory symptoms
• Headache or dizziness
• Stuffy or runny nose
• Stomach discomfort or diarrhea
• Joint or muscle aches

Serious, less common reactions can include pancreatitis, severe joint pain, bullous pemphigoid, kidney issues, or allergic reactions with rash, hives, or swelling. Seek urgent care if you have severe abdominal pain, signs of an allergic reaction, blistering skin lesions, or symptoms of very low blood sugar. Risk of hypoglycemia increases when used with insulin or sulfonylureas.

Drug Interactions and Cautions

Tell your prescriber about all medicines and supplements. Certain agents, like digoxin, may require monitoring. Combining with insulin or sulfonylureas can raise the chance of hypoglycemia. If you have a history of pancreatitis, significant kidney disease, or blistering skin conditions, discuss whether this therapy fits your plan. Alcohol can affect glucose control. Follow the official label and your clinician’s advice on monitoring and lab work.

What to Expect Over Time

With consistent daily use and lifestyle measures, many patients see steadier fasting and post-meal readings. Your clinician may check A1C periodically and adjust your overall plan. If added to existing therapy, it may take more than one refill cycle for your care team to assess the full effect. Keep a glucose log, and carry treatment for low blood sugar if advised. Continue routine checkups to review kidneys, skin, and any abdominal symptoms promptly.

Compare With Alternatives

Some patients use the brand reference product Januvia® when the prescriber prefers a brand. Others may be directed to a combination such as Janumet® if metformin is also required. Your clinician will tailor therapy based on glucose patterns, kidney function, and tolerance.

For an overview of therapies by class, see our Diabetes Drugs List and learn when insulin-based approaches are considered in Types Of Insulin.

Pricing and Access

We highlight Canadian pricing with transparent options for cash-pay customers. If you want to compare Sitagliptin price across strengths, you can browse sizes and manufacturers on this page. For those seeking Sitagliptin 100 mg price details, review the product selector and add the appropriate strength to your cart. US fulfillment is supported through verified Canadian partners, and this item Ships from Canada to US after the prescription is confirmed. For seasonal offers, check our Promotions. Checkout is supported by encrypted systems to protect your information.

Availability and Substitutions

Stock varies by manufacturer and strength. If a specific tablet is unavailable, your prescriber may recommend a suitable alternative or a different strength to meet your plan. Options may include the same active ingredient from another manufacturer or a fixed-dose combination when appropriate. If you prefer brand or generic, discuss equivalence with your clinician. We list country of origin on product pages; see Canada for reference. If you need a Sitagliptin generic option, we can help your prescriber select a therapeutically appropriate product.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults whose glucose remains above goal despite diet and exercise, particularly those needing an oral option. It may be less suitable for people with recurrent pancreatitis, severe kidney impairment without dose adjustment, or a history of hypersensitivity to sitagliptin. Always share your full medical history and medication list with your prescriber.

To manage costs, consider multi-month fills when your prescriber allows. Larger quantities can reduce per-tablet expenses and minimize refill fees. Use refill reminders so you do not miss doses. Review your reading trends at each visit to avoid unnecessary changes. Explore related supplies in Diabetes Care and condition resources under Type 2 Diabetes.

Questions to Ask Your Clinician

• Fit with plan: How does this tablet fit into my current regimen?
• Monitoring: How often should I check glucose and labs?
• Risks: What symptoms suggest pancreatitis or allergic reactions?
• Combinations: Should I adjust insulin or a sulfonylurea to reduce lows?
• Kidneys: What dose suits my kidney function?
• Goals: What A1C and glucose targets should I aim for?

Authoritative Sources

Manufacturer Prescribing InformationFDA DailyMed: SitagliptinHealth Canada Drug Product Database

Ready to get started? Add your strength, upload your prescription, and complete checkout for prompt, express shipping that Ships from Canada to US, with temperature-controlled handling when required. This information is educational and not a substitute for professional medical advice.