Sprycel

Sprycel is a targeted oral medication used to treat certain types of leukemia, including Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) and acute lymphoblastic leukemia (Ph+ ALL). It works by blocking BCR-ABL and other kinases involved in the growth of cancer cells, helping to slow or stop their spread.

Benefits

• Effectively targets BCR-ABL, the abnormal protein driving leukemia in Ph+ CML and Ph+ ALL.
• Often used when patients are resistant or intolerant to other leukemia treatments.
• Helps achieve or maintain remission in both newly diagnosed and previously treated patients.
• Oral tablet offers a convenient at-home treatment option.
• Can be used in both adults and children with appropriate medical supervision.

Dosage

• For adults with chronic phase CML, the usual dose is 100 mg once daily.
• For accelerated or blast phase CML, or Ph+ ALL, the dose is typically 140 mg once daily.
• Pediatric doses are based on body size and medical guidelines.
• Tablets should be taken at the same time each day, with or without food.
• Swallow whole — do not crush, split, or chew the tablets.

Warnings and Precautions

• May cause fluid retention, including around the lungs or heart — monitor for symptoms like shortness of breath or swelling.
• Can lower blood cell counts — regular blood tests are necessary.
• Risk of bleeding, particularly in patients with low platelet counts.
• May affect liver function — liver tests are recommended during treatment.
• Use caution in patients with heart, lung, or liver conditions.
• Not recommended during pregnancy or breastfeeding.

Usage Instructions

• Take exactly as prescribed, once daily at the same time.
• Swallow the tablet whole with a glass of water.
• Do not take antacids or medications that reduce stomach acid within 2 hours before or after taking Sprycel.
• If a dose is missed, take it as soon as remembered unless it’s close to the next dose. Do not double up.
• Follow your doctor’s advice regarding monitoring and follow-up tests.

Storage Information

• Store at room temperature (20°C to 25°C).
• Keep the medication in its original packaging.
• Protect from moisture and heat.
• Store out of reach of children and pets.

Common Side Effects

Mild to moderate effects: low blood cell counts, headache, diarrhea, fatigue, nausea, rash, muscle or bone pain, or swelling in the hands and feet.
Serious (seek medical attention): chest pain, severe shortness of breath, unusual bleeding or bruising, fever or chills, or symptoms of fluid buildup around the lungs or heart.