Ibrance

Uses of Ibrance

Ibrance is used to treat advanced-stage or metastatic, hormone receptor-positive, HER2-negative breast cancer in women or men: in combination with a type of hormonal therapy called an aromatase inhibitor for cancer that hasn’t been treated with hormonal therapy before; Arimidex (chemical name: anastrozole), Aromasin (chemical name: exemestane), and Femara (chemical name: letrozole) are aromatase inhibitors. in combination with the hormonal therapy Faslodex (chemical name: fulvestrant) for cancer that has grown after being treated with hormonal therapy. Pre-menopausal and peri-menopausal women who take Ibrance also should be treated with a medicine to suppress ovarian function.

Precautions and Warnings

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Ibrance is right for you.

In particular, make sure that you discuss any of the following.

Tell your healthcare provider if you have any of the following.

• Have a fever, chills, or any other signs of an infection
• Liver problems
• Kidney problems

Ibrance may cause harm to an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. You must not be pregnant before starting Ibrance. If you can become pregnant, use effective birth control during treatment with Ibrance and for 3 weeks after your last dose. If you are a male who has a female partner that can become pregnant, use effective birth control during treatment with Ibrance and for at least 3 months after your last dose.

Ibrance may cause fertility problems in people who were assigned male at birth. Talk with your healthcare provider if this is a concern for you.

Do not undergo treatment with Ibrance while you are breastfeeding and for 3 weeks after your last dose. It is not known if Ibrance passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.

Ibrance may interact with other medicines and supplements. Before taking Ibrance, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Dosage

Your doctor will recommend the dosage of Ibrance that’s right for you. Below are commonly used dosages, but always take the dosage your doctor prescribes.

Regardless of whether your doctor prescribes Ibrance in tablet or capsule form, you’ll take your Ibrance dose at the same time each day for 21 days. During this period, the recommended dosage of Ibrance is 125 mg taken once daily. Then you’ll stop taking the drug for 7 days.

You’ll continue taking Ibrance in this 28-day pattern, called a cycle, according to your doctor’s instructions.

As part of your treatment, you’ll take Ibrance along with hormone therapy. Your doctor will give you dosage instructions for the type of hormone therapy they recommend for your condition.

Side Effects

Common side effects:

• Blood disorders
• Infections
• Tiredness
• Nausea and vomiting
• Mouth sores
• Hair loss
• Diarrhea
• Rash
• Decreased appetite
• Weakness
• Fever