Komboglyze® Tablets for Type 2 Diabetes

This prescription tablet combines saxagliptin with metformin for adults with type 2 diabetes. It helps improve glycemic control alongside diet and physical activity. This page explains safe use, access, and ways to compare options.

What Komboglyze Is and How It Works

Komboglyze® pairs saxagliptin, a DPP-4 inhibitor, with metformin, a biguanide. You can review access options, including choices without insurance, with US delivery from Canada. Together, these agents reduce hepatic glucose production and help increase incretin activity, which supports glucose‑dependent insulin release.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

The DPP‑4 inhibitor component may help lower post‑meal glucose by preserving incretin hormones. The metformin component can decrease liver glucose output and improve insulin sensitivity. When used with diet and activity, the combination can support A1C reduction over time.

Who It’s For

This therapy is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. It may be suitable for those not at goal on metformin alone or on a DPP‑4 inhibitor plus metformin separately. Avoid use in type 1 diabetes or for diabetic ketoacidosis.

Do not use if you are allergic to Komboglyze ingredients. People with significant kidney disease, unstable heart failure, or a history of lactic acidosis should discuss risks with a healthcare professional. If you are pregnant or breastfeeding, seek guidance before starting. For broader background, see our overview of Type 2 Diabetes.

Dosage and Usage

Follow the approved label and your prescriber’s directions. Typically, tablets are taken with meals to limit stomach upset. Swallow tablets whole with water. Dosing is individualized based on current metformin exposure and the saxagliptin component prescribed. Do not exceed the maximum recommended daily amounts on the official label.

Your clinician may adjust the saxagliptin metformin dosage based on kidney function, tolerability, and glucose targets. If you are transitioning from separate tablets, your prescriber may select an equivalent total daily dose. Report any persistent stomach upset, unusual fatigue, or new symptoms promptly.

Strengths and Forms

Available presentations vary by market and stock. The following are commonly published Komboglyze dosage forms for immediate‑release tablets. Availability on our site may differ:

• 2.5 mg saxagliptin with 500 mg metformin
• 2.5 mg saxagliptin with 850 mg metformin
• 2.5 mg saxagliptin with 1000 mg metformin
• 5 mg saxagliptin with 500 mg metformin
• 5 mg saxagliptin with 850 mg metformin
• 5 mg saxagliptin with 1000 mg metformin

Packaging and tablet markings vary by manufacturer and country of origin.

Missed Dose and Timing

If you miss a dose, take it when remembered with food unless it is almost time for the next scheduled dose. If it is near the next dose, skip the missed dose and resume your regular schedule. Do not double up to make up a missed tablet. If vomiting occurs after a dose, follow your clinician’s advice before taking an extra tablet.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from moisture and direct heat. Keep the bottle tightly closed and out of reach of children. Do not use tablets that are damaged or expired. When you travel, carry the medicine in your hand luggage with a copy of your prescription and your prescriber’s contact information.

For trips, pack an extra small supply and a list of your medicines. Use a daily reminder to keep doses consistent across time zones. Our partners use temperature-controlled handling when required. If you are also using insulin, review practical basics in our article on Insulin Resistance.

Benefits

This combination may reduce tablet burden by pairing two agents in one pill. It can address both fasting and post‑meal glucose patterns when used as directed. As part of therapy, saxagliptin metformin may support A1C improvement over months of consistent use. Taking the medicine with food often improves stomach comfort.

The class pairing may be suitable for those not at goal on metformin alone. Many patients appreciate a simplified schedule under one prescription, which can help adherence.

Side Effects and Safety

• Digestive upset, such as nausea, diarrhea, or stomach discomfort
• Headache or mild dizziness
• Upper respiratory symptoms or nasopharyngitis
• Decreased appetite or metallic taste

Serious but uncommon risks include lactic acidosis with metformin, pancreatitis, allergic reactions, and worsening heart failure with DPP‑4 inhibitors in susceptible patients. Stop the medicine and seek medical care if you develop severe abdominal pain, trouble breathing, swelling of the face or throat, or signs of dehydration. Hypoglycemia can occur when combined with insulin or sulfonylureas; monitor for shakiness, sweating, or confusion.

Drug Interactions and Cautions

Tell your prescriber about all medicines you take. Strong CYP3A4/5 inhibitors or inducers can affect saxagliptin exposure. Diuretics, ACE inhibitors, and ARBs may alter kidney function; monitoring may be needed. Excess alcohol increases lactic acidosis risk and should be limited. Temporarily stop metformin for iodinated contrast procedures as directed on the label. If you also use insulin or a sulfonylurea, your team may consider hypoglycemia precautions.

What to Expect Over Time

Glucose readings may trend down with steady use, meal planning, and activity. Many people notice fewer post‑meal spikes over time. Your clinician may check A1C after a few months to evaluate response. Take the treatment consistently, keep a log of readings, and communicate any side effects. For general guidance on long‑term management and lifestyle change, see our article Diabetes Be Reversed.

Compare With Alternatives

Extended‑release versions exist in some markets; for example, Komboglyze XR may be considered when an extended‑release metformin backbone is appropriate per label. As single‑agent options, a DPP‑4 inhibitor such as Sitagliptin can be used with separate metformin when suitable. We also carry Sitagliptin Malate, which some prescribers use alongside metformin when combination tablets are not available or not preferred.

Pricing and Access

We list transparent options based on Komboglyze Canadian pricing. Many patients pay out of pocket and compare cash‑pay choices before ordering. You can check current availability and place your order with US shipping from Canada. For occasional coupons, visit our Promotions page.

To review other diabetes items you might need, explore our Diabetes Care section.

Availability and Substitutions

Supply can vary by strength and pack size. If a specific tablet is unavailable, your prescriber may recommend a comparable alternative or separate components. We cannot guarantee restock dates. Check back for updates or talk with your clinician about interim options.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults with type 2 diabetes who need dual therapy and tolerate metformin. It may not fit those with advanced kidney disease, active liver issues, or a history of pancreatitis, unless a clinician advises otherwise. If you have heart failure symptoms, discuss risks and benefits in detail.

To manage costs, consider multi‑month fills when appropriate, which can reduce per‑tablet expense and reduce refill trips. Use refill reminders to avoid gaps in therapy. Combining home glucose logs with follow‑up visits helps your clinician optimize your regimen and minimize unnecessary changes.

Questions to Ask Your Clinician

• Starting plan: How should I take the first week of tablets?
• Kidney checks: How often will my kidney function be monitored?
• GI comfort: What should I do if stomach upset persists?
• Low sugar risk: How do I prevent hypoglycemia with insulin or a sulfonylurea?
• Imaging safety: When should I pause metformin for contrast studies?
• Activity plan: Which diet and exercise goals pair best with this therapy?

Authoritative Sources

AstraZeneca Product Information

DailyMed: Saxagliptin/Metformin

Health Canada Drug Product Database

Ready to proceed at BorderFreeHealth? Place your order today for US delivery with prompt, express shipping. This information is not a substitute for professional medical advice; always follow your prescriber and the approved label.