Durolane® Injection for Knee Osteoarthritis

Durolane® is a hyaluronic acid joint injection used for knee osteoarthritis pain relief. You can access Canadian pricing with US delivery from Canada through Border Free Health. You may also compare options if paying without insurance.

What Durolane Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine contains non-animal stabilized hyaluronic acid, a lubricant found naturally in synovial fluid. In osteoarthritis, joint fluid can thin, reducing shock absorption and smooth movement. A Osteoarthritis injection restores viscosity in the joint space, helping the knee move more comfortably. The material acts like a cushion and lubricant, which may ease pain during daily activities.

The Durolane injection is administered by a trained healthcare professional into the knee joint. It is a single-use, prefilled syringe intended for intra-articular use only. This therapy is not self-injected at home. Your prescriber will decide if one or both knees are appropriate for treatment based on your symptoms and exam.

Who It’s For

Durolane for knee osteoarthritis is indicated for adults with pain due to degenerative changes in the knee. It may be considered when oral pain relievers, topical agents, or physical therapy are not enough. People with active skin infections, joint infections, or significant inflammation at the injection site should not receive a shot until those issues resolve.

Avoid this treatment if you have known sensitivity to hyaluronic acid products or any syringe components. Tell your clinician if you are pregnant, breastfeeding, on blood thinners, or have bleeding disorders; your prescriber will weigh potential risks and benefits. It is not intended for children.

For broader reading on arthritis care, you may find these helpful: Celebrex And Arthritis and Metformin For Osteoarthritis.

Dosage and Usage

This therapy is given as a single intra-articular injection by a clinician in a medical setting. The knee is prepared with antiseptic, and a needle is placed into the joint space using standard sterile technique. Any fluid may be removed before the product is injected, per the prescriber’s judgment. The hyaluronic acid injection is then delivered slowly into the joint.

After your appointment, follow your clinician’s activity guidance. Many prescribers recommend avoiding strenuous or high-impact exercise for a short period. Gentle walking is often acceptable, but your healthcare professional will provide specific instructions. Do not attempt to reuse the syringe; it is single-use only and is disposed of safely at the clinic.

If symptoms return later, your clinician may discuss whether another injection is appropriate. Decisions about repeat treatment are individualized and should follow the official product instructions for use and your prescriber’s advice.

Strengths and Forms

The product is supplied as a sterile, prefilled 3 mL syringe for single use. A commonly listed presentation is Durolane 60mg/3mL sodium hyaluronate. Availability may vary by country and by pharmacy partner.

Missed Dose and Timing

If you miss a scheduled clinic visit, contact your provider to reschedule. Do not self-inject or attempt to store an opened syringe for later use. Timing of future injections is determined by your prescriber based on clinical response and the official instructions for use.

Storage and Travel Basics

If your clinic asks you to bring the syringe to your appointment, keep the carton intact and follow the storage guidance on the package insert. Protect it from freezing and excessive heat, and keep it out of direct sunlight. Store out of reach of children and pets. Do not use if the packaging is damaged or if the product is past its labeled expiry date.

When traveling to a visit, carry the syringe in its original carton and keep it with you rather than in checked baggage. If your airline requires documentation, bring your prescription or appointment note. Do not attempt to attach needles or open the packaging before your prescriber’s instructions at the clinic.

Benefits

This treatment supplements the joint with a viscous lubricant that may reduce friction and improve comfort. Many patients appreciate the single-visit approach compared with multi-injection series used by some alternatives. The injection is localized to the knee, which helps limit systemic exposure typical of certain oral pain relievers. This can be helpful for people who cannot tolerate higher doses of nonsteroidal anti-inflammatory drugs.

Side Effects and Safety

• Injection site pain or tenderness
• Temporary swelling or joint effusion
• Warmth, redness, or mild bruising around the knee
• Joint stiffness or a feeling of fullness

Serious effects are uncommon but can include infection, allergic reaction, or severe inflammation. Seek urgent care for fever, severe pain, rapidly increasing swelling, or warmth and redness that spreads. This product is for intra-articular use only; it must not be injected into blood vessels or tissues outside the joint. Tell your clinician about any prior reactions to hyaluronic acid products.

Drug Interactions and Cautions

Provide a complete medication list to your prescriber, including anticoagulants, antiplatelet agents, immunosuppressants, and herbal supplements. Your clinician will consider bleeding risk, infection risk, and any recent procedures around the knee. Do not receive the injection into a joint with an active infection or if there are skin diseases or wounds at the intended site. Follow antiseptic instructions given by the medical team to reduce the chance of infection.

Some device instructions advise avoiding contact with certain disinfectants in the syringe area. Your provider will manage product preparation using approved materials and technique.

What to Expect Over Time

Relief typically develops gradually after the visit. People often notice changes during regular activities such as walking, climbing stairs, or standing from a seated position. Keeping a brief symptom diary can help you and your clinician judge progress. If comfort improves, your prescriber may recommend complementing the injection with exercise therapy, weight management, or braces as appropriate. If pain recurs later, discuss whether another injection fits your plan.

Compare With Alternatives

Several approaches can help knee osteoarthritis. Oral prescription NSAIDs are common choices when tolerated. For example, Celecoxib is a COX-2 selective NSAID, and Meloxicam is a long-acting option used widely in arthritis care. These medicines work through systemic anti-inflammatory effects, while viscosupplementation targets the joint locally. Your clinician will weigh your health history, current medicines, and goals when considering these alternatives.

For additional reading, see Meloxicam 15 Mg and How Long Celebrex Works.

Pricing and Access

The Durolane price varies by supplier and market conditions. With our Canadian partners, you can view transparent cash-pay options and compare with local clinics. We offer Canadian pricing with fulfillment that Ships from Canada to US. If you are deal-seeking, check our Promotions page for current offers. Checkout is encrypted for your privacy. If you are paying without insurance, you can still review choices and plan with your prescriber before purchasing.

To see other pain-care options, explore Pain Inflammation and learn about coverage differences by country of origin such as Canada.

Availability and Substitutions

Supply can vary. If the product is temporarily unavailable, your prescriber may recommend a different viscosupplement or a separate class such as an oral NSAID. The choice depends on your symptoms, knee imaging, other conditions, and prior responses. We do not promise restock dates. Your clinician’s guidance should drive any substitution.

Patient Suitability and Cost-Saving Tips

Good candidates typically have knee osteoarthritis confirmed by clinical evaluation and imaging when needed. People who cannot tolerate certain oral medicines sometimes prefer localized injections. Those with joint or skin infections at the site should wait until fully treated. Tell your clinician about bleeding tendencies, recent procedures, or allergies before scheduling.

To manage the Durolane cost, consider these practical steps:

• Multi-month planning: discuss if scheduling future visits makes sense for you
• Bundle errands: align appointments to reduce time and travel expenses
• Set reminders: use calendar alerts for clinic visits and follow-ups
• Ask your prescriber: clarify expected quantity and timing to avoid extra trips
• Compare approaches: review oral and topical alternatives for budget fit

Questions to Ask Your Clinician

• Is a single injection appropriate for my knee findings?
• How will you guide activity and exercise after the visit?
• What signs would suggest I should call the clinic promptly?
• Could oral NSAIDs or braces complement this therapy for me?
• Are there reasons I should avoid an injection right now?
• What is your approach if symptoms return later?

Authoritative Sources

Manufacturer IFU

FDA Summary

Health Canada Listing

Ready to proceed? Start your order with prompt, express shipping and temperature-controlled handling when required. This page is informational and does not replace your clinician’s advice; always follow the official instructions for use.