Genvoya Tablets (150/150/200/10 mg)

Genvoya is a prescription, once-daily, single-tablet HIV-1 regimen that combines four antiretroviral medicines in one pill. It is used as part of long-term treatment to help control the virus, not to cure HIV. This page summarizes dosing basics, interactions, side effects, and practical handling so it’s easier to read the label and discuss care with a clinician.

BorderFreeHealth is a referral platform that helps coordinate access to prescription medicines for cash-pay patients, including those without insurance. Ships from Canada to US for eligible prescriptions through our partner network. Information below is general and should be checked against the official prescribing information.

What Genvoya Is and How It Works

This medicine is a fixed-dose combination (four drugs in one tablet). It is considered an antiretroviral therapy (ART) regimen that targets HIV replication at more than one step. Two components are nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), one is an integrase strand transfer inhibitor (INSTI), and one is a pharmacokinetic enhancer (a “booster” that raises levels of another drug).

Dispensing is coordinated through licensed Canadian partner pharmacies.

The INSTI portion blocks integrase, an enzyme HIV uses to insert viral genetic material into human DNA. The NRTI components slow reverse transcriptase, another enzyme HIV needs to copy itself. The booster does not treat HIV directly; instead, it can increase the amount of the INSTI in the blood by slowing its breakdown. Because the product is a complete regimen, it is not typically combined with other HIV medicines unless a specialist specifically directs that plan.

Who It’s For

This treatment is indicated for HIV-1 infection in certain adults and some adolescents, depending on the label criteria. Clinicians consider prior treatment history, resistance test results when available, kidney function, liver health, and other medicines before selecting a complete regimen. For broader context, the HIV Condition Hub is a browsable collection of related topics and categories.

It may not be appropriate for everyone. People with significant kidney impairment may need a different option, because some components are cleared through the kidneys. Screening for hepatitis B virus (HBV) is also important because two ingredients have activity against HBV; stopping those drugs can be associated with HBV worsening in people who have both infections. A prescriber will also review pregnancy considerations, age/weight criteria for adolescents, and whether any contraindicated medications are being used.

Some people also want to understand testing and monitoring steps that happen before starting or changing ART. The article Types Of HIV Tests offers a plain-language overview of common lab tests used in care.

Dosage and Usage

For most patients on label, Genvoya is taken once daily with food. Taking it with a meal helps the body absorb key components more reliably. Tablets are swallowed whole; they are not intended to be split or crushed unless a clinician specifically confirms an alternative approach based on authoritative guidance.

Why it matters: Consistent daily dosing helps prevent resistance and preserves future treatment options.

If a dose is missed, the product labeling provides practical missed-dose instructions based on how much time has passed. In general, doubling up is avoided, and timing matters when other interacting products are involved. If vomiting occurs soon after a dose, directions differ from a late missed dose, so it is worth checking the official labeling and documenting the timing for the next clinical visit.

Strengths and Forms

Genvoya tablets are a fixed-dose combination supplied as an oral tablet. The commonly referenced strength is 150/150/200/10 mg (listed on packaging as the amount of each component per tablet). Because it is a complete regimen, there is no separate “titration pack” for building up doses; the prescriber selects it based on eligibility criteria and the patient’s medication profile.

Many pharmacies dispense this medicine in a 30-tablet count, but packaging can vary by market and distributor. When transferring care or changing pharmacies, it helps to confirm the exact product name and strength on the prescription to avoid mix-ups with other combination HIV tablets that may look similar.

Storage and Travel Basics

Store the tablets at controlled room temperature and protect them from excess moisture. Many manufacturers recommend keeping the medicine in its original container with the desiccant (drying agent) if included, and keeping the lid tightly closed. Avoid storing in bathrooms, cars, or other areas with frequent temperature swings.

For travel, carry the medication in hand luggage so it stays within a reasonable temperature range. Keeping a copy of the prescription label or a medication list can help during security screening and when seeking urgent care away from home. If the container is bulky, ask the dispensing pharmacy whether a smaller, properly labeled travel container is appropriate.

Quick tip: Pack a few extra doses in case of travel delays.

Side Effects and Safety

Like many antiretroviral regimens, Genvoya can cause side effects, and most are manageable with monitoring and good communication. Commonly reported effects may include nausea, diarrhea, headache, fatigue, or trouble sleeping. Some people notice skin changes such as rash; a rash can be mild, but any widespread rash, blistering, fever, or swelling should be treated as urgent and evaluated promptly.

Prescriptions are confirmed with the original prescriber before the pharmacy fills.

More serious risks can involve kidney function, liver problems, and changes in the immune system as viral control improves (immune reconstitution inflammatory syndrome, meaning the immune system “wakes up” and reacts to hidden infections). Lab monitoring often includes kidney markers and liver enzymes, especially when other conditions or medications add risk. People with HIV and HBV co-infection need careful planning before stopping any regimen containing HBV-active components, because HBV symptoms can worsen after discontinuation.

Weight change is discussed frequently in HIV care. Weight loss is not a typical goal of ART, and unexpected weight changes should be assessed for broader causes such as diet changes, other medications, thyroid disease, or uncontrolled infection.

Drug Interactions and Cautions

This regimen has clinically important interactions because one component affects liver enzymes and transporters that control how many drugs are metabolized. Some medications are contraindicated (should not be used together) due to the risk of dangerous levels, loss of HIV control, or serious side effects. Examples may include certain seizure medicines, rifamycin antibiotics, specific heart rhythm drugs, and herbal products such as St. John’s wort. Always cross-check a full medication list, including over-the-counter products and recreational substances.

Vitamins, minerals, and antacids

People often ask about genvoya interactions with vitamins and mineral supplements. Products that contain polyvalent cations (such as aluminum, magnesium, calcium, or iron) can reduce absorption of some integrase inhibitors. Antacids, multivitamins, and buffered supplements are common sources. The label may recommend separating dosing by a specific number of hours for certain antacids; spacing guidance can differ by product type. It is helpful to write down brand names and amounts so a pharmacist can check the most accurate separation plan.

Alcohol does not directly interact with the antiviral mechanism, but heavy use can worsen liver disease and reduce medication adherence. Grapefruit interactions are not the main concern here; the bigger issues are enzyme-inducing drugs that can lower levels of key components and strong inhibitors that can raise other drugs to unsafe levels.

For more background on HIV medication choices over time, see Evolving HIV Treatment Landscape. For questions about emergency prevention rather than ongoing treatment, the article Biktarvy As PEP Guide provides general context to discuss with a clinician.

Compare With Alternatives

When clinicians compare complete HIV regimens, they often look at prior resistance, kidney and bone health, hepatitis B status, pregnancy considerations, drug–drug interactions, and how forgiving a regimen is to missed doses. Integrase inhibitor–based single-tablet options are common, but there are also regimens built on boosted protease inhibitors or non-nucleoside reverse transcriptase inhibitors (NNRTIs). Each approach has tradeoffs, and the “best” option depends on the full clinical picture.

Genvoya is one complete regimen; it is not interchangeable with other combinations without prescriber review. Some people also take antivirals for other infections, which should not be considered substitutes for HIV treatment. Examples of other antivirals listed on the site include Vemlidy (used for chronic hepatitis B) and Vosevi (used for hepatitis C), which have different indications and interaction profiles.

Browsing the Antivirals Category can help locate related therapies by condition and class, then confirm specifics with the prescribing clinician.

Pricing and Access

Genvoya pricing can vary based on pharmacy source, prescription details, and whether coverage is available. Some patients use insurance benefits, while others rely on cash-pay arrangements, including situations without insurance. If assistance programs are being explored, it helps to gather income documentation, a current medication list, and the prescribing clinic’s contact details so eligibility questions can be handled efficiently.

Border Free Health supports cross-border access pathways using cash-pay when coverage is limited.

Refills require an active prescription and may require periodic follow-up visits and lab work, depending on the clinician’s care plan. For site-related options that may affect out-of-pocket spending, see Payment Support Options. For customers receiving US shipping from Canada, it is also important to plan ahead for continuity, since clinic renewals and pharmacy verification can take coordination.

Medication access works best when the pharmacy has the most up-to-date prescriber information, including fax numbers and clinic addresses. If a prescriber changes, updating records early can prevent refill delays caused by incomplete verification details.

Authoritative Sources

For the most accurate, up-to-date details on indications, contraindications, and interaction lists, consult official references. These sources are especially helpful when reviewing complex medication profiles or when switching from another HIV regimen.

• FDA overview and labeling details: Drugs@FDA Application Overview
• NIH patient-friendly drug information: ClinicalInfo HIV Drug Record

If placing an order through the site, select prompt, express shipping at checkout when available.

This content is for informational purposes only and is not a substitute for professional medical advice.