Janumet XR® Tablets for Type 2 Diabetes

This combination medicine lowers blood sugar in adults with type 2 diabetes. It brings two proven approaches together in one daily tablet. This page explains how it works, who it suits, and how you can get it through our service.

We provide access with US delivery from Canada, including options for those paying without insurance.

What Janumet XR Is and How It Works

Janumet XR® combines sitagliptin, a DPP-4 inhibitor, and metformin, a biguanide. Together, they help the body release more insulin when needed and reduce glucose made by the liver. The XR design slowly releases the ingredients to support steady control. Learn more about the condition at Type 2 Diabetes and see a helpful overview in Janumet Blood Sugar.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

As sitagliptin boosts incretin hormones, it can help your pancreas respond after meals. Metformin decreases hepatic glucose output and can improve insulin sensitivity. This paired mechanism may support A1C reduction when diet and activity alone are not enough.

If you read about Glucophage Vs Metformin, you will see how the biguanide component fits into therapy. The combination simplifies scheduling by using once-daily dosing in an extended-release form.

Many people tolerate this class well. Some may notice stomach symptoms at first. Taking the tablet with a meal often helps.

For search clarity, the generic class name appears as an exact phrase here once: sitagliptin metformin HCl XR tablets. This refers to the components and release profile used in this medicine.

Who It’s For

This treatment is indicated for adults with type 2 diabetes, as an add-on to diet and exercise. It is not for type 1 diabetes or diabetic ketoacidosis. People with significantly reduced kidney function should avoid metformin-containing products. Those with liver disease or alcohol misuse may face higher lactic acidosis risk and should discuss safer options.

If you have a history of pancreatitis, tell your clinician before starting this therapy. Report severe abdominal pain, especially if it radiates to the back. Individual suitability depends on medical history, lab values, and current medicines.

Dosage and Usage

Use this medicine exactly as directed by your prescriber. Most adults take it once daily with a meal, commonly the evening meal. Swallow tablets whole. Do not crush, split, or chew, as that can change the extended-release profile.

Starting doses are usually based on prior metformin tolerance and kidney function. Your prescriber may adjust the dose to help reach individualized goals. If you see a tablet shell in your stool, that is expected with XR technology.

Keep regular follow-ups for A1C, kidney function, and B12 levels when advised. For more support items, see Diabetes Care.

Strengths and Forms

This medicine is supplied as extended-release tablets in several combination strengths. Common presentations include 50/500 mg, 50/1000 mg, and 100/1000 mg. Availability can vary by partner pharmacy and manufacturer lot.

For clarity in product searches, one commonly referenced pairing is sitagliptin metformin XR 50/1000 mg. Your exact strength is determined by your prescriber.

Missed Dose and Timing

If you miss a dose, take it when you remember with food. If it is close to your next scheduled dose, skip the missed dose and return to your routine. Do not take two doses at once. Try using a daily reminder to keep doses consistent.

Storage and Travel Basics

Store the tablets at room temperature in a dry place. Keep the bottle tightly closed and away from moisture and heat. Use the original container with the child-resistant cap. Do not use past the expiration date.

When traveling, pack your medicine in carry-on luggage. Bring a copy of your prescription and a medication list. Keep tablets out of direct sunlight in a secure bag. If crossing borders, allow extra screening time and keep labels visible for security checks.

Benefits

This dual-agent approach can reduce pill burden compared with taking two separate medicines. The extended-release design may improve comfort for those sensitive to metformin’s gastrointestinal effects. Once-daily use can support adherence, which is important for steady control.

Because the two components target different pathways, the combination may help address fasting and post-meal glucose patterns as part of a broader plan with nutrition and activity.

Side Effects and Safety

• Stomach upset or diarrhea
• Nausea or decreased appetite
• Headache
• Upper respiratory symptoms

Serious effects are uncommon but need prompt attention. Metformin can rarely cause lactic acidosis, especially with significant kidney or liver disease, dehydration, or heavy alcohol use. Sitagliptin has been associated with pancreatitis and hypersensitivity reactions. If you have severe abdominal pain, shortness of breath, extreme fatigue, or a rash with swelling, seek urgent care.

Low blood sugar is unlikely when used alone, but the risk can increase when combined with insulin or a sulfonylurea. Your clinician may adjust those agents to reduce hypoglycemia risk.

Drug Interactions and Cautions

Tell your healthcare professional about all prescription, nonprescription, and herbal products you use. Important considerations may include:

• Iodinated contrast imaging procedures
• Alcohol intake and dehydration risks
• Drugs that affect kidney function
• Insulin and sulfonylureas that can lower glucose
• Carbonic anhydrase inhibitors

Discuss upcoming imaging studies, acute illness, or surgeries. Review sick-day rules to prevent dehydration, which can impact kidney function. For background reading, see Types Of Insulin and Insulin Resistance.

What to Expect Over Time

With consistent use, many people see gradual improvements in fasting and post-meal readings as part of a broader plan. A1C changes are assessed over months, since red blood cells turn over slowly. Routine labs guide decisions about dose, adherence, and whether another class should be added.

Keep a simple log of daily doses and any side effects. If stomach upset occurs early, taking the tablet with the largest meal can help. Review progress at follow-up visits and ask about nutrition, activity, and sleep strategies that complement therapy. For broader context, visit Diabetes Drugs List.

Compare With Alternatives

Other options for type 2 diabetes include single-agent DPP-4 inhibitors and different combination tablets. If your prescriber prefers separate components, you might discuss sitagliptin as a standalone DPP-4 inhibitor, or a sulfonylurea such as glimepiride, depending on goals and tolerance.

We offer related options, including Janumet and Sitagliptin. Your prescriber will decide which approach aligns with your medical history and lab targets.

Pricing and Access

We list current options so you can compare Janumet XR price across available pack sizes. Cash-pay customers can view Canadian-origin products clearly labeled. We support fulfillment that Ships from Canada to US, and we show key details up front so you can plan purchases without insurance.

You can check our latest offers on Promotions. Country sourcing information appears on product pages and attribute filters such as Canada.

Availability and Substitutions

Stock can vary by strength and manufacturer. If an item is temporarily unavailable, your prescriber may recommend a comparable alternative or separate components. Some orders may be sourced internationally according to your prescription and regulations. For search clarity, we note that some customers look for Janumet XR from Canada. You can also explore potential alternatives sourced from India when appropriate.

Patient Suitability and Cost-Saving Tips

Candidates often include adults whose A1C remains above goal on lifestyle measures or metformin alone. Those with eGFR below label thresholds, active liver disease, or a history of pancreatitis may need a different plan. Discuss your full medication list and alcohol intake to reduce risks.

To manage costs, consider multi-month fills if your prescriber agrees. Setting refill reminders can prevent gaps in therapy. Many patients search to buy sitagliptin metformin XR as a way to compare options across dose strengths. Reviewing sourcing and pack sizes can help you find a schedule that fits your budget and travel plans.

Questions to Ask Your Clinician

• Is this combination right for my A1C goals?
• How should I time doses with meals?
• What lab tests will we monitor over time?
• What signs suggest pancreatitis or lactic acidosis?
• Could any of my other medicines interact?
• When would we add or switch to another class?

Authoritative Sources

Manufacturer: Merck

FDA Prescribing Information

Health Canada Drug Product Database

Ready when you are: place your prescription request and order Janumet XR online with prompt, express shipping and US shipping from Canada, with temperature-controlled handling when required. This information is educational and not a substitute for professional medical advice; always follow your prescriber’s directions.