Leqvio® Injection for High Cholesterol

Leqvio® is a prescription injection used with statins to reduce LDL cholesterol in adults. This page explains how it works, who it suits, and how you can access lower Canadian options with US delivery from Canada, even if you pay without insurance. You will also find safety basics and practical tips for ordering, storage, and travel.

What Leqvio Is and How It Works

Leqvio is the brand name for inclisiran, a small interfering RNA therapy that helps the liver clear more LDL cholesterol from the bloodstream. As an Inclisiran injection, it reduces PCSK9 production in liver cells. With less PCSK9 circulating, LDL receptors can recycle more effectively, which can lower LDL-C when used alongside diet and statin therapy.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine is typically administered by a healthcare professional. It targets the PCSK9 pathway differently from monoclonal antibodies, using RNA interference inside hepatocytes. That intracellular action supports sustained LDL-C lowering when the maintenance schedule is followed. Always review the official label for full details on use and safety.

You can also explore related condition pages to see broader care topics, including High Cholesterol and Mixed Dyslipidemia, plus cardiovascular options in our Cardiovascular category.

Who It’s For

Leqvio indications include use as an adjunct to diet and maximally tolerated statin therapy to reduce LDL-C in adults with primary hyperlipidemia, including those with established atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia. It may be considered when LDL-C remains above goal despite statins and lifestyle changes, or when additional LDL-C reduction is desired.

People with known hypersensitivity to inclisiran or any component should not receive it. Those who are pregnant, planning pregnancy, or breastfeeding should discuss risks and benefits with a healthcare professional, as human data are limited. Individuals with severe hepatic impairment or advanced kidney disease require careful evaluation by a prescriber.

Your clinician may also discuss background options such as fibrates like Lipidil Supra, or statins including Pravastatin Sodium and Rosuvastatin Calcium, depending on your current plan and treatment goals.

Dosage and Usage

The usual schedule starts with a first dose, then a second dose 3 months later, followed by maintenance every 6 months thereafter. Inclisiran injections are administered subcutaneously, typically by a clinician, in the abdomen, thigh, or upper arm. It is used in combination with ongoing statin therapy and diet measures unless a prescriber has directed otherwise.

On the day of your appointment, wear clothing that allows easy access to the injection site. Let your prescriber know about any recent infections, planned procedures, or changes in your medicines. Continue statins as directed unless your clinician advises a change. This page does not replace the official label, which should guide decisions when uncertain.

Strengths and Forms

This therapy is supplied as a single-dose prefilled syringe for subcutaneous injection. A commonly available presentation is 284 mg/1.5 mL. Availability may vary by market and by pharmacy. Talk with your prescriber about the presentation that matches your prescription and care setting. As a Leqvio medication, it is typically clinic-administered rather than self-injected at home.

Missed Dose and Timing

If a scheduled dose is missed, contact your healthcare professional to reschedule as soon as practical. After the missed dose is given, the next maintenance dose is generally set 6 months from the date of the last injection. Timing guidance is qualitative here; follow the official label and your prescriber’s plan for exact scheduling.

Storage and Travel Basics

Storage recommendations are based on the official label. Prefilled syringes are usually kept refrigerated in the original carton until use and protected from light. Do not freeze. If your clinic asks you to bring the syringe, transport it according to their instructions and keep it in the carton until administration. Avoid vigorous shaking and extreme temperatures during travel. As a general safeguard, we support temperature-controlled handling when required.

For trips, carry your prescription and clinic appointment details. Use a travel case if instructed by your clinic. Do not remove the needle cap. Keep medicines out of reach of children. If you experience delays, contact the clinic for guidance.

Pen Handling and Sharps Disposal

This treatment is supplied in a prefilled syringe, not a pen device. In most cases, a clinician administers the dose and manages sharps disposal on site. If you ever receive different instructions, follow your prescriber’s technique guidance and local regulations for sharps disposal. Never recap used needles or discard syringes in household trash.

Benefits

As a PCSK9-targeting therapy delivered by a clinician, the treatment may support substantial LDL-C reductions when combined with statins and diet. The dosing schedule can aid adherence after the initial phase, with twice-yearly maintenance visits. Patients who struggle with frequent self-injections may appreciate the clinic-based schedule.

Some patients and prescribers also use this option when LDL targets are not met on statins alone. The class acts inside the liver, which differentiates it from antibody therapies that bind PCSK9 in the bloodstream. These characteristics can help with Leqvio cholesterol management alongside lifestyle changes and careful monitoring.

For broader heart-health context, you can explore our article World Heart Day 2025.

Side Effects and Safety

• Injection-site reactions: redness, pain, swelling, or rash
• Joint or muscle aches
• Respiratory symptoms such as cough or bronchitis
• Urinary tract infection
• Diarrhea or nausea
• Pain in extremity or back

Serious reactions are uncommon but can include hypersensitivity. Seek urgent care for signs such as facial swelling, severe rash, or trouble breathing. Tell your clinician about liver or kidney concerns, recent illnesses, and all medicines and supplements you use. Because it is usually given with statins, report any unexplained muscle pain or weakness promptly. This overview does not list every possible effect; use the official label for complete information.

Drug Interactions and Cautions

Few drug-drug interactions are anticipated because inclisiran is not a CYP inhibitor or inducer. However, always provide your full medication list to your prescriber, including statins, fibrates, antiplatelets, anticoagulants, and herbal products. People with severe hepatic impairment or significant renal disease require individualized assessment. The manufacturer is Novartis, and official labeling guides use, monitoring, and safety considerations. Discuss pregnancy and breastfeeding plans with a healthcare professional before starting this therapy.

What to Expect Over Time

After the start and 3-month doses, maintenance typically proceeds every 6 months. Your healthcare professional may check fasting lipids to evaluate response and adjust your overall plan. Many people continue their background statin and heart-healthy habits. Staying on schedule, keeping appointments, and communicating side effects can help you and your prescriber track progress effectively. If goals are not met, your clinician may discuss adding, switching, or sequencing other lipid-lowering options.

Compare With Alternatives

Antibody therapies that also target PCSK9 can be appropriate alternatives for some patients. Options include Repatha and Praluent. These medicines work in the bloodstream to bind PCSK9, whereas inclisiran reduces PCSK9 production in the liver. Dosing schedules and administration settings differ, so discuss preferences, monitoring, and coverage with your prescriber.

Pricing and Access

We offer transparent listings so you can review the Inclisiran injection price and see current availability. Canadian pharmacy rates can support meaningful savings for many U.S. patients, with US shipping from Canada. To explore time-limited offers, visit our Promotions page.

Savings CTA: You can compare options, estimate cash-pay savings, and see how Canadian rates may fit your budget. Pricing CTA: When ready, add the item to your cart to view live pricing, then upload your prescription for verification.

Availability and Substitutions

Supply can vary by formulation and market conditions. If an item is unavailable, your prescriber may recommend a suitable alternative or adjust your plan. We do not guarantee restock dates, but our team updates availability as we receive new information.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults who need added LDL-C reduction beyond statins and diet and who prefer clinic-based dosing. It may not be appropriate for those with hypersensitivity to components or for certain patients with severe hepatic disease. If you and your prescriber choose this option, consider scheduling maintenance visits ahead to stay on track.

• Multi-month planning: align refill timing with your clinic visits
• Budgeting: review annual costs vs. monthly expenses
• Reminders: set calendar alerts for injections and labs
• Lifestyle: continue diet, exercise, and smoking cessation
• Care team: coordinate with your cardiology or primary care clinic

If your plan includes adjuncts, your clinician may consider combinations such as Caduet in appropriate cases. You can also learn about general buying considerations in our article Prescription Vs Otc. For product sourcing, see our Country Of Origin attribute to confirm Canadian supply expectations.

Questions to Ask Your Clinician

• Is this treatment right for my LDL-C goal and ASCVD risk?
• How will it fit with my current statin and other medicines?
• What side effects should I watch for after each visit?
• How often will you check my lipid panel and liver tests?
• If I miss an appointment, how should we reset the schedule?
• Are there alternatives if I do not meet goal on this plan?

Authoritative Sources

Novartis Leqvio Product PageFDA DailyMed: Inclisiran Prescribing InformationHealth Canada DPD: Inclisiran

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Disclaimer: This page is educational and does not replace medical advice. Use only as prescribed. Read the official label and consult your healthcare professional for guidance specific to you.