Nobivac® Canine Lepto 4 Vaccine for Dogs

Nobivac Canine Lepto 4 is a veterinary vaccine that helps protect dogs from leptospirosis caused by four common serovars. It is used as part of a routine prevention plan for at-risk pets. This page explains indications, schedules, handling, and how to order with US shipping from Canada, including options for those paying without insurance.

What Nobivac Lepto 4 Is and How It Works

Nobivac® Canine Lepto 4 is an inactivated (killed) bacterin vaccine formulated to help protect healthy dogs against leptospirosis due to Canicola, Grippotyphosa, Icterohaemorrhagiae, and Pomona serovars. After the primary series, the immune system produces antibodies that may reduce the risk of illness if the dog is exposed. This Canine Lepto 4 vaccine is typically given by subcutaneous injection, as directed on the official label.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

The treatment fits into standard canine vaccination schedules. It may be administered alone or during visits when other core vaccines are due, following veterinary guidance. Always review the product insert for full indications, handling, and precautions.

Who It’s For

This leptospirosis 4-way dog vaccine is indicated for healthy dogs as young as eight weeks of age, according to many product labels. It is commonly recommended for dogs that go outdoors, contact standing water, encounter wildlife, or live in regions where leptospirosis is documented. Dogs in urban areas can be exposed through rodents or contaminated water, so risk assessment is not limited to rural settings.

Dogs that are moderately or severely ill should not be vaccinated until they recover. Use caution in pregnant or breeding animals unless the label specifically permits use. Discuss history of vaccine reactions with a veterinarian before administering any dose. See our condition overview for background on exposure and transmission in dogs: Leptospirosis.

Dosage and Usage

Follow the label for dose and schedule. A typical primary series uses a 1 mL dose given subcutaneously, followed by a second dose 2 to 4 weeks later. Annual revaccination is commonly recommended thereafter. Shake well before use, and administer with a sterile needle and syringe for each animal. Do not mix this medicine with other products in the same syringe unless the label allows it.

Many practices pair the lepto series with core vaccines, spacing appointments to support an appropriate response. The Nobivac Lepto 4 1 dose format fits routine appointments for single patients. Keep accurate vaccination records, including manufacturer, lot number, and date, to support travel and boarding requirements.

Strengths and Forms

Availability can include single-dose packs and multi-dose vials. Clinics often choose unit doses for individual dogs and larger vials for higher-volume settings. Check current stock before placing an order, as pack sizes may vary by batch and fulfillment partner.

Common presentations include a single 1 mL dose and a Nobivac Lepto 4 10 dose vial used in clinic settings. Some suppliers also carry bulk multipacks for professional use. Selection may vary by season and region.

Missed Dose and Timing

If the second dose in the primary series is delayed, consult the overseeing veterinarian for next steps. Many labels advise completing the two-dose series with the same product when feasible. If a substantial interval has passed, the prescriber may recommend restarting the series to ensure coverage. For annual boosters, plan ahead to keep revaccination on schedule.

When multiple vaccines are due, clinicians may space injections to minimize the chance of overlapping reactions. The Nobivac Lepto 4 single dose format can simplify scheduling for individual patients.

Storage and Travel Basics

Store the vaccine refrigerated as directed on the label. Do not freeze. Protect from light. Use within the specified time after opening multi-dose vials. Transport with appropriate refrigeration to maintain product integrity. For clinics that receive shipments, follow documented receiving procedures and record storage temperatures if required by local policy.

When ordering through BorderFreeHealth, cold-chain handling is prioritized for biologics. References to Nobivac Lepto 4 refrigerated shipping reflect the need to keep the vaccine at label-recommended temperatures through fulfilment. If you must travel with doses, use insulated carriers and consult the label before transport. Keep out of reach of children and animals. As a general site practice, temperature-controlled handling when required is supported.

Benefits

As part of the leptospirosis prevention plan, this medicine helps protect against four serovars associated with clinical disease. Using a killed bacterin can be appropriate for dogs at risk of exposure from water sources, rodents, or wildlife. The treatment fits standard appointment workflows, with a primary series followed by yearly revaccination in many programs.

Clinic-friendly packaging supports both individual and multi-patient needs. Clear scheduling and record-keeping help maintain coverage. When paired thoughtfully with other canine vaccines, the overall plan can reduce gaps and avoid unnecessary extra visits.

Side Effects and Safety

• Injection site soreness or mild swelling
• Transient fever, lethargy, or decreased appetite
• Brief discomfort at the time of injection

Serious allergic reactions can occur rarely with any vaccine. Signs can include facial swelling, hives, vomiting, diarrhea, or collapse. Immediate veterinary care is required if a severe reaction is suspected. Use caution in dogs with a history of hypersensitivity. Do not use in sick animals unless advised by a veterinarian. Read the label for species, age, and use limitations, and report adverse events through appropriate channels.

Drug Interactions and Cautions

Avoid mixing with other vaccines or medications in the same syringe unless the label specifically permits it. Immunosuppressive therapies may reduce the response to vaccination. Use aseptic technique and a new sterile needle and syringe for each dog. Dispose of sharps safely following local regulations. Do not use if the product has been frozen or shows signs of compromise.

Keep a clear schedule for the primary series and annual revaccinations. If the animal is on antibiotics or other treatments, the prescriber can advise on timing relative to vaccination. See our pet category for general products that may be used alongside vaccines when clinically appropriate: Pet Medications.

What to Expect Over Time

After the initial series, many dogs transition to yearly boosters. Mild, short-lived reactions are the most common experiences and typically resolve without specific care. The preventive plan is most effective when timed appropriately and maintained consistently.

Travel, boarding, and grooming facilities may require proof of vaccination. Maintain organized records so the information is available when needed. If a visit is missed, reschedule promptly to keep the plan on track.

Compare With Alternatives

Clinics often evaluate different canine vaccine combinations to streamline schedules. For core antigens, some practices use a DAPPv option alongside a separate lepto series. See alternatives we stock, such as Canine 1 Dappv for core coverage, or Puppy DPV for young dogs starting their series. Selection depends on age, risk factors, and clinic protocol.

Pricing and Access

Canadian sourcing can help clinics manage budgets for routine biologics. We provide transparent listings so you can review options before checkout. For practices comparing packages, multi-dose vials may offer operational value. This leptospirosis dog vaccine 4 serovar is offered with clear product details to support informed purchasing.

See current options and availability online with US delivery from Canada. If you plan promotions or seasonal clinics, check our site for periodic offers: Promotions. For background on related therapies that may appear in canine care plans, you can also review our educational guides such as Doxycycline For Dogs and What Is Clavamox.

Availability and Substitutions

Stock may vary by season. If a preferred pack size is unavailable, a prescriber may recommend an equivalent schedule with a different presentation. We will display current availability on the product page. For broader sourcing options, see our country-of-origin attribute page: Canada.

Patient Suitability and Cost-Saving Tips

Healthy dogs in areas with documented leptospirosis risk are common candidates. Dogs with prior vaccine reactions require individual assessment. Sick animals should generally wait until recovery before vaccination. Breeding status, age, and concurrent therapies can influence decisions, as outlined on the label and by the prescriber.

To manage clinic workflows and budgets, consider ordering multi-dose vials for high-volume days, and unit doses for sporadic appointments. Build reminders to schedule second doses and annual revaccinations. Combine appointments thoughtfully to reduce extra visits while maintaining immunization timing.

Questions to Ask Your Clinician

• Is my dog at risk for leptospirosis exposure where we live?
• When should we begin the primary two-dose series?
• Can we give this alongside core vaccines, or space them out?
• What mild reactions should I monitor after the injection?
• How do we handle a delayed second dose or booster?
• Which pack size works best for our clinic schedule?
• What records are required for boarding or travel?

Authoritative Sources

Merck Animal Health

USDA Center for Veterinary Biologics

Health Canada Drug Product Database

Ready to proceed? Start checkout for prompt, express shipping and clinic-friendly pack options. Content on this page is educational and not a substitute for professional veterinary advice. Always follow the product label and the prescriber’s instructions.