Orilissa® Tablets for Endometriosis Pain

Orilissa® is a prescription medicine used to help manage moderate to severe pain from endometriosis. It is taken by mouth and works by lowering ovarian hormone levels that drive symptoms. This page explains how the treatment works, who it may suit, and how you can order with US delivery from Canada, including options if paying without insurance.

What Orilissa Is and How It Works

This medicine is a gonadotropin-releasing hormone (GnRH) antagonist. It reduces luteinizing hormone and follicle-stimulating hormone, which lowers estrogen. As estrogen falls, pain linked to endometrial lesions may lessen. Elagolix is the active ingredient. Effects are dose- and time-dependent, so your prescriber selects a course based on symptoms and risk factors.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Because estrogen decreases during therapy, periods can change or stop. Bone mineral density can decline over time, so treatment duration is limited per labeling. Non-hormonal birth control is recommended during treatment and for one week after the final dose.

You can review the official label for complete details and warnings. If anything here seems unclear, follow your prescriber’s advice and the patient information leaflet supplied with your tablets.

Learn more about the condition at our Endometriosis page.

Who It’s For

This therapy is indicated for adults with moderate to severe endometriosis pain, including pelvic pain and pain with sex. It is not for use in pregnancy. People with known osteoporosis, severe liver disease, or a history of suicidal ideation may require different options. Those with moderate hepatic impairment may need shorter courses.

Non-hormonal contraception should be used. Combined estrogen-containing birth control can affect how this treatment works and is generally not recommended with it. Adolescents and postmenopausal individuals were not the primary studied groups.

For broader women’s health options, see our Womens Health category.

Dosage and Usage

The dosing schedule follows the official label and your prescriber’s directions. Typical courses include a once-daily option for a longer duration, and a higher twice-daily option for a shorter time when symptoms are more severe. Elagolix dosing may differ for patients with liver impairment or when certain interacting medicines are used.

Take tablets at the same time each day, with or without food. Swallow whole with water. Use effective non-hormonal birth control while taking this therapy and for one week after the final dose. If a clinician discusses lab tests or bone health monitoring, those checks help balance symptom relief and safety.

For labeled uses and safety, rely on the patient information leaflet and your prescriber.

Strengths and Forms

This treatment is supplied as film-coated oral tablets in two commonly available strengths. Availability can vary by partner pharmacy.

• Elagolix 150 mg tablets
• 200 mg tablets

Not all package sizes may be available at all times.

Missed Dose and Timing

If you miss a dose and remember on the same day, take it as soon as you remember. If you do not remember until the next day, skip the missed dose and take the next dose at the usual time. Do not take two doses at once to make up for a missed tablet.

Try setting a daily reminder or pairing dosing with a routine activity to support consistency.

Storage and Travel Basics

Store tablets at room temperature in the original container, away from moisture and light. Keep out of reach of children and pets. Do not store in a car or in direct sunlight. When traveling, carry your prescription-labeled container in your hand luggage. Bring a copy of your prescription or a photo of the label to help with security checks.

Pharmacies use temperature-controlled handling when required. For online orders, keep the package insert for reference while you are away from home.

Benefits

This therapy can reduce pelvic pain and pain during intercourse associated with endometriosis. Oral dosing avoids clinic visits for injections. Treatment durations are defined to manage risks while providing symptom relief. Different dosing options allow clinicians to tailor a plan to symptom pattern and tolerability.

Some people appreciate that periods may become lighter or stop during use. Others prefer predictable cycles; talk to your prescriber about what matters most to you, as choices can reflect your goals.

Side Effects and Safety

Common Orilissa side effects may include hot flashes, night sweats, headache, nausea, trouble sleeping, mood changes, and irregular or absent periods. These effects often relate to lower estrogen levels.

• Hot flashes or warmth
• Headache or fatigue
• Nausea or decreased appetite
• Difficulty sleeping
• Mood changes or irritability
• Changes in menstrual bleeding

Serious risks can include bone density loss, new or worsening depression, suicidal thoughts, liver enzyme increases, and allergic reactions. Contact a healthcare professional right away if you notice severe mood symptoms, yellowing of the skin or eyes, severe abdominal pain, or signs of an allergic reaction.

If you have a history of fractures, osteoporosis, or significant liver problems, discuss whether this therapy is a good fit. Clinicians may check bone health and liver tests as needed.

Drug Interactions and Cautions

Some medicines can change levels of this therapy. Strong OATP1B1 inhibitors such as cyclosporine or gemfibrozil can raise exposure and are generally contraindicated. Strong CYP3A inhibitors such as ketoconazole may increase levels; strong inducers such as rifampin can lower them after repeated use. St. John’s wort may also reduce effect.

Hormonal contraceptives containing estrogen can alter effectiveness. Use reliable non-hormonal contraception during treatment and for one week after stopping. If you take medicines with a narrow therapeutic index, ask your prescriber to review for interactions.

For education on related women’s therapies, see Imvexxy Uses and our brief overview, What Is Hirsutism.

What to Expect Over Time

Symptoms may begin to improve during the first several weeks, though the time course varies. Pain scores often change as hormone levels stabilize. Because bone mineral density can decline with ongoing use, duration is intentionally limited by dose selection. Your prescriber may reassess symptoms and risks during therapy to decide whether to continue or adjust the plan.

Periods may become infrequent or stop. Some people experience hot flashes or sleep changes that ease with time. If side effects persist, share details with your healthcare professional to consider supportive strategies.

Compare With Alternatives

Other options for endometriosis pain include progestin therapies and, in some cases, surgical approaches. In settings where it is used, Dienogest can be considered for symptom control under a prescriber’s guidance. Choice depends on symptom pattern, tolerance, bone health considerations, and future fertility goals.

If contraception is a priority during treatment planning, discuss methods suited to your needs; some combined hormonal products may not be appropriate alongside this therapy. One option to review with a clinician is Nextstellis, though compatibility must be assessed.

Pricing and Access

Canadian pharmacy pricing can help you compare options. To see the current Orilissa price, visit the product page and select your quantity. Live pricing reflects our partner pharmacy supply. For potential savings and any current offers, check our Promotions page. We also support US shipping from Canada with transparent checkout.

If you are paying cash, you can compare costs across fills to plan ahead. Some patients look for a manufacturer or pharmacy coupon; availability changes, and requirements vary by program. If you need help, you can contact support on the product page.

Availability and Substitutions

Supply can vary by dose and package size. If this medicine is temporarily unavailable, your prescriber may recommend an alternative that fits your history and goals. We do not promise restock dates, but the catalog updates as inventory changes.

For context on sourcing, you can browse items manufactured in Canada.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with endometriosis pain who do not have severe liver disease or established osteoporosis. It is not for pregnancy. If you have depression or mood concerns, mention them before starting. Anyone with a history of low-trauma fracture should discuss bone health.

• Multi-month planning: ask your prescriber if a longer fill makes sense.
• Set reminders: calendar alerts help maintain adherence.
• Coordinate renewals: request refills before your last week.
• Travel ready: pack tablets in your carry-on with the label.
• Insurance review: compare cash-pay vs plan coverage when applicable.

Staying consistent often improves symptom control. If adverse effects arise, share specifics with your clinician rather than stopping on your own.

Questions to Ask Your Clinician

• Is this GnRH antagonist a good fit for my pain pattern?
• Which dose and duration balance symptom relief and bone health?
• How should I handle contraception while on this therapy?
• Which medicines or supplements should I avoid during treatment?
• What signs suggest I should contact you promptly?
• Will I need blood tests or bone health checks during use?

Authoritative Sources

• Manufacturer Prescribing Information
• FDA DailyMed: Full Label
• Health Canada Drug Product Database

Ready to proceed? You can add the item to your cart, complete checkout, and choose prompt, express shipping. Content here is educational and not a substitute for professional medical advice.