Piqray

Piqray is an oral targeted therapy used to treat certain types of advanced or metastatic breast cancer. It works by blocking the PI3K-alpha enzyme, which helps slow the growth and spread of cancer cells in patients with a specific PIK3CA gene mutation.

Benefits

• Specifically targets and inhibits the PI3K pathway in PIK3CA-mutated breast cancer.
• Helps slow cancer progression and improve treatment outcomes when used with hormone therapy.
• Oral medication, taken at home for convenience.
• Offers a precision-medicine approach based on genetic testing.

Dosage

• The usual dose is 300 mg once daily, taken as two 150 mg tablets.
• Should be taken at the same time each day with food.
• Dose may be reduced based on side effects or medical guidance.
• Tablets must be swallowed whole — do not crush or split.

Warnings and Precautions

• Can cause high blood sugar (hyperglycemia); blood glucose should be monitored regularly.
• Not recommended in patients with uncontrolled diabetes.
• May increase the risk of serious skin reactions or allergic responses.
• Liver and kidney function should be monitored during treatment.
• Avoid use during pregnancy and breastfeeding.
• Inform your doctor about all medications, including over-the-counter drugs and supplements.

Usage Instructions

• Take Piqray once daily, at the same time, with food.
• Swallow tablets whole with water.
• If a dose is missed by more than 9 hours, skip it and take the next dose at the usual time.
• Do not take two doses to make up for a missed one.
• Continue treatment as prescribed unless advised otherwise by your doctor.

Storage Information

• Store at room temperature (20°C to 25°C).
• Keep tablets in original packaging until ready to use.
• Protect from moisture, heat, and light.
• Keep out of reach of children.

Common Side Effects

• Mild to moderate effects: high blood sugar, diarrhea, rash, nausea, decreased appetite, fatigue, or weight loss.
• Serious (seek medical attention): severe skin reactions, breathing difficulties, signs of infection, persistent high blood sugar, or symptoms of liver issues like dark urine or yellowing of the skin.