Prometrium® Capsules for Secondary Amenorrhea and Endometrial Protection

This progesterone capsule is used for secondary amenorrhea and to help protect the uterine lining when estrogen therapy is prescribed. This page explains uses, dosing, safety, and practical tips so you can decide with your prescriber. We also outline Prometrium cost without insurance so you can plan.

What Prometrium Is and How It Works

Micronized progesterone Prometrium® is an oral progesterone made to match the hormone your body produces. It supports the transition of the endometrium from the growth phase to the secretory phase. That action helps reduce the chance of estrogen-alone therapy thickening the lining too much. For people with absent periods not due to pregnancy, this medicine can trigger a withdrawal bleed after a short course.

We offer US shipping from Canada for your order through our platform. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

The capsule may cause drowsiness or dizziness. Taking it at bedtime helps many people tolerate therapy. The branded product contains peanut oil, so anyone with a peanut allergy must avoid it.

Who It’s For

This treatment is indicated for two groups: nonhysterectomized postmenopausal adults taking estrogen who need endometrial protection, and adults with secondary Amenorrhea not due to pregnancy. People who have had a hysterectomy generally do not need a progestin for lining protection.

Do not use it if you have undiagnosed vaginal bleeding, a peanut allergy, active liver disease, known or suspected breast cancer, a history of blood clots, stroke, or heart attack, or known or suspected pregnancy. If unexpected bleeding occurs, your prescriber should evaluate for causes such as Abnormal Uterine Bleeding.

Dosage and Usage

Follow your prescriber and the official label. Typical schedules are:

• With estrogen therapy: 200 mg by mouth once nightly for 12 days of each 28-day cycle.
• For secondary amenorrhea: 400 mg by mouth once nightly for 10 days.

Oral Prometrium should be swallowed whole. Taking the capsule at bedtime reduces the impact of sleepiness or dizziness. You can take it with a light snack if sensitive to stomach upset. Keep to the same time each evening. If you notice spotting or heavy bleeding on therapy, contact your healthcare professional for guidance.

Strengths and Forms

Available strengths are Prometrium 100 mg and 200 mg capsules. The branded capsule includes peanut oil; generic progesterone capsules may have different excipients. Color and imprint can vary by manufacturer. Availability may differ by pharmacy and country.

Missed Dose and Timing

If you miss a bedtime dose, take it when you remember unless it is close to the next evening dose. If it is near the next dose, skip the missed one and resume your usual schedule. Do not double up. Because it can cause drowsiness, avoid driving or operating machinery after taking your dose.

Storage and Travel Basics

Store capsules at room temperature as directed on the package. Keep them in the original, child-resistant bottle with the label intact. Protect from excessive heat, moisture, and light. When traveling, carry the medicine in your hand luggage with a copy of your prescription. If crossing time zones, aim to keep a consistent bedtime schedule at your destination. Keep out of reach of children and pets.

Benefits

This therapy supports the lining of the uterus when estrogen is used and helps lower the risk of excessive buildup. For those with absent periods not due to pregnancy, a short course can help induce a withdrawal bleed. Bedtime dosing is convenient for many and can reduce daytime sleepiness. Using the same hormone the body produces may improve tolerability for some patients under a clinician’s guidance.

Side Effects and Safety

• Sleepiness and dizziness, especially after dosing
• Headache or fatigue
• Breast tenderness
• Bloating or abdominal cramps
• Mood changes or irritability
• Vaginal spotting or breakthrough bleeding

Serious risks are uncommon but can include allergic reactions (including to peanuts in the branded capsule), vision changes, severe headache, chest pain, leg swelling, or jaundice. When combined with estrogen, progestins are part of regimens that carry warnings about blood clots, stroke, heart attack, and certain cancers in some patients. Seek urgent care for symptoms of clotting or severe allergic reaction.

Drug Interactions and Cautions

Certain medicines may affect progesterone levels, including enzyme inducers like rifampin, carbamazepine, and phenytoin, and inhibitors such as ketoconazole or certain antibiotics and antivirals. Alcohol and sedatives can worsen drowsiness. St. John’s wort may lower effectiveness. Liver disease, depression, and a history of clotting require special caution. Report all medicines and supplements to your prescriber.

People on systemic estrogen therapy should periodically reassess risks and benefits. Bone health, breast health, and cardiovascular status are important parts of the discussion and follow-up.

What to Expect Over Time

With estrogen therapy, adding a progestin can result in predictable monthly withdrawal bleeding on combined cyclic regimens. For secondary amenorrhea, a bleed may occur after the course ends. Many people feel drowsy at night shortly after starting. If daytime grogginess persists, speak with your clinician about timing. Keep regular follow-ups to review symptoms and any bleeding changes. For a broader view of midlife health, you may find our article on Early Signs Of Osteoporosis helpful for discussion with your care team.

Compare With Alternatives

Some patients and prescribers consider other options based on goals. For vulvovaginal symptoms without a need for endometrial protection, local estrogen such as Vagifem may be chosen. For moderate to severe dyspareunia due to menopause, the selective estrogen receptor modulator Osphena is another prescription option. Your prescriber can help match therapy to your history and goals.

Pricing and Access

You can review current Prometrium price and compare options on our product page. We highlight Canadian pricing and US shipping from Canada so you can plan your budget with your prescriber. For occasional special offers, see our Promotions. Checkout is encrypted to protect your information. For broader women’s health choices, explore our Womens Health category.

Availability and Substitutions

Stock and manufacturers may vary. If a specific brand is unavailable, your prescriber may recommend an appropriate alternative or authorize a generic progesterone capsule when suitable. We do not guarantee restock dates. If your bottle or capsule appearance changes, check the label and talk to your pharmacist or clinician before use.

Patient Suitability and Cost-Saving Tips

This medicine may be suitable for adults who need endometrial protection with estrogen or who are treating secondary amenorrhea, and who do not have contraindications like peanut allergy, active liver disease, or a history of clots. Those with a uterus removed usually do not need a progestin for estrogen therapy. To reduce costs, ask your prescriber about multi-month fills. Setting refill reminders helps prevent gaps. If your plan does not cover it, ask about generic options and whether a different regimen fits your needs.

Questions to Ask Your Clinician

• Is this capsule appropriate for my condition and health history?
• What schedule should I follow, and for how long?
• How will we monitor bleeding, mood, and side effects?
• Could any of my medicines or supplements interact?
• What should I do if I feel very drowsy during the day?
• Are generic progesterone capsules an option for me?
• How often should we reassess my estrogen plus progestin plan?

Authoritative Sources

FDA DailyMed: Prometrium Prescribing Information

FDA Labeling: Progesterone Capsules

Health Canada Drug Product Database

Ready when you are. Start your request with prompt, express shipping and US shipping from Canada. This information is not a substitute for professional medical advice; always follow your prescriber and the official label.