Repatha® Injection for High LDL Cholesterol

Repatha® is a prescription PCSK9 inhibitor used to lower LDL cholesterol. This medicine helps adults and some children who need additional LDL-C reduction with diet and statin therapy. Many patients compare Repatha cost without insurance to understand options before starting treatment.

What Repatha Is and How It Works

This treatment contains evolocumab, a monoclonal antibody that targets PCSK9. By blocking PCSK9, it helps preserve LDL receptors on the liver, so more LDL cholesterol is cleared from the blood. You can access it with US delivery from Canada through our platform. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

It is used alongside diet and, when appropriate, statins or other lipid-lowering therapies. The medicine does not replace a heart-healthy lifestyle. Your prescriber decides if this therapy fits your overall plan.

Who It’s For

This therapy is indicated for adults with primary hyperlipidemia, including heterozygous familial hypercholesterolemia, who need more LDL-C lowering in addition to diet and maximally tolerated statins. It is also used to reduce risk in patients with clinical atherosclerotic cardiovascular disease. Some pediatric patients may qualify depending on age and diagnosis; your healthcare professional will follow the official label.

People with a history of serious allergy to components should not use it. If you are pregnant, planning pregnancy, or breastfeeding, discuss potential risks and alternatives with your prescriber. Learn more about related conditions in our categories for High LDL Cholesterol and Familial Hypercholesterolemia.

Dosage and Usage

Typical adult dosing for primary hyperlipidemia is 140 mg every two weeks or 420 mg once monthly, taken as instructed by your prescriber. For certain familial hypercholesterolemia cases, a 420 mg schedule may be used; some patients on apheresis may need different timing. Always follow the official label and your clinician’s directions.

Allow the autoinjector or prefilled syringe to warm to room temperature before use, without heating devices. Inject into the thigh, abdomen, or upper arm, rotating sites and avoiding tender, bruised, or scarred skin. The Repatha SureClick 140 mg/mL device is designed for single-use only. If you are unsure how to administer, ask a healthcare professional to teach you.

Strengths and Forms

Commonly available presentations include a prefilled SureClick autoinjector and a prefilled syringe, each delivering 140 mg per injection. Some regions previously offered an on-body infusor for the 420 mg once-monthly option; availability can vary. Your prescriber may recommend three 140 mg injections in one day for the monthly dose when appropriate. Product options may differ by supplier and market.

Missed Dose and Timing

If you miss a dose and the next dose is due soon, general guidance is to take it as soon as possible and then follow the label-recommended instructions for reorganizing your schedule. For monthly dosing, many patients restart counting from the day the missed dose is taken. For every-two-week dosing, if you are close to the next dose, you may be advised to skip and resume. When uncertain, consult the official label or your prescriber.

Storage and Travel Basics

Store this medicine in the refrigerator in the original carton to protect from light. If needed, it can be kept at room temperature for a limited period as described on the label; do not freeze or shake. Keep out of reach of children. For travel, carry it in a small insulated pouch and bring a copy of your prescription. Airline screening staff may ask to see your medication and devices.

Some specialty items require temperature-controlled handling when required. At home, never reuse needles or devices, and dispose of used items safely after each dose.

Pen Handling and Sharps Disposal

Before injection, inspect the solution; do not use if cloudy, discolored, or with particles. Allow the device to warm up naturally. Clean the site with an alcohol wipe and let it dry. Follow the device’s start, hold, and completion steps as instructed in the patient guide.

• Device prep: gather supplies and check expiration date.
• Site selection: rotate thigh, abdomen, or upper arm.
• Steady pressure: hold the device until the indicator shows completion.
• Aftercare: apply light pressure if needed; avoid rubbing.
• Disposal: place the device into an FDA-cleared sharps container.

Local rules may allow alternative disposal methods; ask your pharmacist or visit a community sharps program if available.

Benefits

As an adjunct to diet and statins, this treatment can further reduce LDL-C. It offers flexible dosing options that fit many schedules. Autoinjector devices simplify administration at home, which may support adherence over time. Explore broader heart-health topics in our Cardiovascular category.

Side Effects and Safety

• Common: nasopharyngitis, upper respiratory tract infection, influenza-like symptoms.
• Injection site: redness, pain, or bruising at the injection area.
• Other reported: back pain, cough, or mild dizziness.

Serious reactions are uncommon but can include hypersensitivity such as rash or swelling of the face or tongue. Seek urgent care for signs of severe allergy. Neurocognitive effects have been reported rarely. If you use insulin or sulfonylureas, this therapy does not increase hypoglycemia risk directly, but discuss your full regimen with your clinician.

Drug Interactions and Cautions

Based on labeling, no clinically significant drug-drug interactions are expected. Still, share a full medication list, including over-the-counter drugs and supplements. Tell your prescriber about medical conditions, past reactions to biologics, and upcoming surgeries or apheresis sessions. For comprehensive risk information, consult the FDA label or Health Canada product monograph.

Patients with established cardiovascular disease may also use statins or ezetimibe. Your prescriber will tailor your plan. For background reading, see our category on Atherosclerotic Cardiovascular Disease.

What to Expect Over Time

LDL-C reduction can begin after you start doses, and your prescriber may check lipids to gauge response. Expect routine labs and periodic assessments to confirm the regimen and administration technique. Stick to your schedule, use reminders, and keep follow-up visits. If your plan includes additional lipid-lowering therapies, your care team will coordinate the overall approach.

For practical insights on lifestyle alongside therapy, you may find our article helpful: Advantages Of Rosuvastatin.

Compare With Alternatives

Two prescription alternatives on our platform include Praluent (alirocumab), another PCSK9 monoclonal antibody, and Leqvio (inclisiran), a small interfering RNA given less frequently. Your prescriber chooses based on your history, LDL-C goals, and dosing preferences.

Pricing and Access

Many patients compare Repatha price across sources to budget for therapy. We show transparent listings so you can review evolocumab price and available presentations before you order. Our model provides Canadian pricing with US shipping from Canada to your address after prescription verification. If you are looking for coupons, check our Promotions page for current offers and guidance. Final costs depend on your prescribed form and quantity.

Availability and Substitutions

Supply can vary by presentation. If a device or pack size is unavailable, your prescriber may suggest a different presentation or an alternative medicine. Pharmacists dispense only against a valid prescription according to regulations. Talk with your care team about timing if you are transitioning between forms.

Patient Suitability and Cost-Saving Tips

Good candidates can inject at home, keep regular lab checks, and follow dosing schedules. If you struggle with self-injection, a caregiver or clinic visit may help. For budgeting, consider multi-month quantities when appropriate, set refill reminders, and coordinate renewals to avoid gaps. Some patients track the Repatha cash price and compare it with pharmacy benefit coverage. If you use statins, you can also review generics like Atorvastatin 90 Tablets or Pravastatin with your prescriber.

Questions to Ask Your Clinician

• LDL-C goals: what target fits my risk profile?
• Dosing choice: every two weeks or once monthly?
• Device training: who can teach me proper technique?
• Lab monitoring: how often should lipids be checked?
• Co-therapy: should I continue or adjust my statin or ezetimibe?
• Travel plans: how do I store the device safely on trips?

Authoritative Sources

• Amgen Prescribing Information
• FDA DailyMed
• Health Canada Drug Product Database

Ready to proceed? Add this medicine to your cart for prompt, express shipping with US shipping from Canada after your prescription is verified. This page is informational and not a substitute for medical advice; follow your prescriber and the official label.