Retevmo® Capsules for RET-Positive Lung and Thyroid Cancers

This prescription targeted therapy treats certain RET-altered cancers. It helps manage advanced lung and thyroid tumors under a clinician’s care. This page explains how the capsules work, who they suit, and ways to access Retevmo without insurance.

What Retevmo Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Thyroid Cancer and Lung Cancer linked to RET changes may respond to this medicine. Ships from Canada to US is available through our cross-border model for eligible prescriptions. Retevmo® is the brand name for selpercatinib, a selective RET kinase inhibitor. The treatment blocks abnormal RET signaling that drives tumor growth in some non-small cell lung and thyroid cancers. Retevmo selpercatinib capsules are taken by mouth and used under specialist supervision. This medicine can be part of a comprehensive plan that includes testing for RET fusions or mutations.

Selpercatinib’s activity targets tumors with RET gene alterations. It may be used in metastatic disease or when cancers progress after prior therapy, as described in official labeling. Your oncology team confirms biomarker status and monitors safety throughout treatment.

Who It’s For

The therapy is indicated for adults with metastatic RET fusion-positive non-small cell lung cancer. It is also used for adults with RET-mutant medullary thyroid cancer and for certain RET fusion-positive thyroid cancers that need systemic therapy, including when radioactive iodine is not appropriate. Some pediatric patients may qualify per label; the prescriber determines suitability.

Selpercatinib capsules are not for people with known severe hypersensitivity to ingredients. Use caution with a history of significant QT prolongation, uncontrolled hypertension, or serious liver disease. Pregnancy and breastfeeding should be avoided during treatment; talk with a healthcare professional about contraception and timing. Learn more about specific cancers at Medullary Thyroid Cancer and Non Small Cell Lung Cancer.

Dosage and Usage

The standard schedule is twice daily, taken about 12 hours apart. Swallow capsules whole with water. Do not open or crush them. You may take doses with or without food, unless your clinician provides specific instructions due to interacting medicines.

Acid-reducing agents can affect exposure. Avoid proton pump inhibitors when possible. If an H2 blocker is necessary, follow label guidance for timing separation. With antacids, separate by at least a few hours. Avoid grapefruit products because they can change medicine levels.

Liver tests and blood pressure are monitored regularly. The prescriber may adjust, pause, or stop therapy if certain lab values change or side effects occur. Only a clinician should change dosing. If uncertain about your regimen, consult the official label or your care team.

Strengths and Forms

This therapy is supplied as oral capsules. Common presentations include Retevmo 80 mg capsules and a lower-strength option. Availability may vary by pharmacy and lot.

Missed Dose and Timing

If you miss a dose and the next one is more than several hours away, take the missed dose when remembered. If the next dose is soon, skip the missed dose and resume the usual schedule. If you vomit after a dose, do not take an extra capsule. Return to the regular timing with the next dose. When labeling varies, follow the official package information or your prescriber’s directions.

Storage and Travel Basics

Keep capsules at room temperature in the original container, tightly closed, and away from moisture. Store out of reach of children and pets. Do not transfer to pill organizers unless advised by your clinician or pharmacist.

For travel, keep the prescription bottle in your carry-on bag. Bring a current medication list and a copy of the prescription. If crossing borders, carry documentation. When packing, protect from excessive heat or humidity. Use a reminder system on your phone so you do not miss doses while away.

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Pen Handling and Sharps Disposal

No pen devices or sharps are used. These are oral capsules, so standard sharps disposal does not apply.

Benefits

This targeted therapy focuses on the RET pathway, aiming to limit growth signals in RET-altered tumors. Oral dosing can reduce clinic time compared with some infusions. The regimen may be combined with routine lab and blood pressure checks so your care team can manage tolerability. Some patients find the capsule format easier to integrate with daily activities, though adherence remains essential.

Side Effects and Safety

• Digestive changes: diarrhea, constipation, nausea, abdominal pain
• Mouth and taste: dry mouth, mouth sores
• General: fatigue, headache, swelling in limbs
• Skin: rash
• Blood pressure: increased readings
• Liver: increased liver enzymes on tests

Serious risks can include liver injury, interstitial lung disease or pneumonitis, QT prolongation, severe hypertension, bleeding events, and allergic reactions. This medicine can harm an unborn baby. Regular monitoring helps detect issues early. Seek urgent care for breathing problems, severe chest pain, significant bleeding, or signs of liver trouble such as yellowing of the eyes or skin. Review the full prescribing information for comprehensive safety details.

Drug Interactions and Cautions

Strong CYP3A inducers can reduce exposure and should be avoided. Strong or moderate CYP3A inhibitors may raise levels; your prescriber may adjust or choose alternatives. Avoid grapefruit. Use caution with other QT-prolonging agents. Acid-reducing agents, as noted above, can affect absorption; follow timing guidance if they are necessary. Tell your healthcare professional about all medicines, vitamins, and herbal supplements you take.

What to Expect Over Time

Most people start with regular follow-up visits, lab tests, and blood pressure checks. Imaging is scheduled by the oncology team. Some side effects may appear early and then settle after adjustments. Others may require ongoing management. It can take time to understand how this therapy fits your routine. Keep a simple dose log and note any symptoms for your visits. If your prescriber changes concomitant medicines, ask whether timing with selpercatinib should be updated.

Compare With Alternatives

Several targeted options exist for biomarker-selected cancers. Choice depends on tumor genetics and prior treatments. For EGFR-mutated NSCLC, your clinician may consider Tagrisso®. For NTRK fusion-positive tumors, the option Vitrakvi® may be used. Other agents, such as ALK or ROS1 inhibitors, apply when those drivers are present. Your prescriber will match therapy to your specific results and clinical context.

Pricing and Access

Canadian pharmacies often provide competitive rates for oncology therapies. Check the Cancer category and country-of-origin details under Canada. We post current options so you can review Retevmo price and available strengths. For occasional savings opportunities, see our Promotions page. US shipping from Canada is supported when your prescription is verified.

Self-pay buyers sometimes look for Retevmo Canadian pricing and cash-pay options. Final checkout reflects pharmacy supply and your prescriber’s directions. You can compare costs with your clinic’s in-house dispensing or local outlets before you place an order.

Availability and Substitutions

Supply can vary by strength and manufacturer lot. If an item is unavailable, your prescriber may recommend a suitable alternative based on your biomarkers and treatment history. We cannot promise restock dates. Your oncology team will guide substitutions if needed.

Patient Suitability and Cost-Saving Tips

Candidates usually have documented RET alterations and meet clinical criteria for systemic therapy. People with uncontrolled blood pressure, significant QT prolongation, or serious liver disease may need closer oversight. Those who are pregnant or planning to become pregnant should discuss risks and timing with their prescriber.

To manage expenses, consider multi-month fills when appropriate. Ask your clinician to send refills so you can avoid gaps. Setting calendar reminders helps keep dosing consistent. If you switch concomitant medicines, reconfirm interaction guidance for this therapy. For broader cancer topics, see Cabometyx Treatment and Fulvestrant Injection.

Questions to Ask Your Clinician

• RET status: which alteration was found and how it guides therapy
• Dosing plan: how my schedule fits with other medicines
• Monitoring: which labs and scans are planned and how often
• Side effects: what to watch for and when to call
• Interactions: acid reducers, CYP3A agents, and grapefruit considerations
• Fertility and pregnancy: contraception and breastfeeding guidance
• Access: pharmacy coordination, refill timing, and travel plans

Authoritative Sources

Manufacturer Prescribing Information

FDA DailyMed Label

Health Canada Drug Product Database

Ready to proceed? You can review options and buy Retevmo online with prompt, express shipping and temperature-controlled handling when required. This information is not a substitute for professional medical advice; always follow your prescriber’s guidance.