Trulance® Tablets for Chronic Idiopathic Constipation

What Trulance Is and How It Works

Trulance® is a prescription tablet for adults with chronic idiopathic constipation and IBS-C. It contains plecanatide, a guanylate cyclase-C agonist that acts locally in the gut. The treatment helps increase intestinal fluid and supports regular bowel movements.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

We provide US delivery from Canada so you can order from home with a valid prescription. If you have questions about Trulance price without insurance, this page outlines access, dosing, safety, and storage so you can plan with your prescriber.

Who It’s For

This medicine is approved for adults with chronic idiopathic constipation and for adults with irritable bowel syndrome with constipation. It is not for children under 6 years due to the risk of severe dehydration. Use is not recommended in patients 6 to under 18 years. Anyone with a known or suspected bowel obstruction should not use this therapy.

Talk with your healthcare professional if you have severe or persistent diarrhea, dehydration risks, or other gastrointestinal diseases. Tell your prescriber about all medicines and supplements you use before starting this treatment.

Dosage and Usage

The usual plecanatide dose is one tablet once daily. You may take it with or without food. Swallow whole when possible. If you cannot swallow, the tablet may be crushed and mixed with applesauce or dissolved in water and swallowed immediately. Follow the official label for detailed steps and disposal of any unused mixture.

Take the medicine at the same time each day. Drink fluids regularly unless your prescriber advises otherwise. Do not change your schedule without guidance. If symptoms do not improve or worsen, consult your healthcare professional rather than taking extra doses.

For caregivers preparing doses for others, review the medication guide to ensure the tablet is handled properly and the mixture is used right away.

Strengths and Forms

This treatment is supplied as oral tablets. Many markets list Plecanatide 3mg tablets in blister packaging to protect from moisture. Availability, packaging, and labeling can vary by supplier and country of origin. Your final dispensed item will match your prescription and local regulatory requirements.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once. Consistent daily use tends to support steadier symptom control.

Storage and Travel Basics

Store tablets at typical room temperature in the original blister to protect from moisture. Keep the medicine dry, away from excessive heat, and out of reach of children and pets. Do not use tablets that are damaged or discolored.

When you travel, keep the original packaging and your prescription details with you. Pack the tablets in a carry-on to avoid temperature swings. If you use a pill organizer, keep at least part of the supply in the blister until needed. Our partners maintain temperature-controlled handling when required during transit.

Benefits

This class of therapy acts in the intestine with minimal systemic absorption. Many patients appreciate once-daily dosing and the option to take with or without food. The tablets can be prepared in applesauce or water if swallowing is difficult, which may help adherence for some adults.

Side Effects and Safety

• Diarrhea
• Abdominal pain or cramping
• Gas or bloating
• Nausea
• Dizziness or headache

Severe diarrhea can lead to dehydration and may require medical care. Stop the medicine and contact a healthcare professional if you develop severe or persistent diarrhea, blood in stool, or signs of dehydration such as dizziness, decreased urination, or extreme thirst. Do not use in children under 6 years. Avoid use in patients with known or suspected mechanical gastrointestinal obstruction.

Drug Interactions and Cautions

Plecanatide has minimal systemic absorption, and clinically relevant interactions are uncommon. However, diarrhea can alter the absorption of other oral medicines. Use caution with drugs that require consistent exposure for effect. Tell your prescriber about all prescription medicines, over-the-counter products, and supplements, including laxatives or antidiarrheals.

If you have kidney or liver disease, are pregnant or breastfeeding, or have a history of severe dehydration, discuss risks and benefits with your prescriber. Read the medication guide for a full list of warnings and precautions.

What to Expect Over Time

Response can vary. Some people notice softer, more regular stools after steady daily use. Others may require more time and supportive measures, such as adequate fluids and dietary fiber as advised by a clinician. Keep a simple symptom log, noting stool consistency and frequency, to discuss at follow-up visits.

If loose stools occur, pause nonessential laxatives and contact your prescriber for advice. Do not double doses to catch up. Consistent daily use is a common approach your clinician may recommend if the medicine is well tolerated.

Compare With Alternatives

Other prescription options for constipation include agents with different mechanisms as well as therapies for IBS symptom control. Your prescriber may consider antispasmodics when abdominal cramping predominates. For IBS-D, different medicines are used than for IBS-C.

For cramp relief in IBS, some patients are prescribed Dicyclomine Hcl. For IBS-D specifically, prescribers may choose Viberzi. These medicines are not the same as plecanatide and treat different symptom profiles. Decisions should follow your diagnosis and treatment goals.

Pricing and Access

Canadian supply routes can offer competitive cash-pay options. If you want to compare Plecanatide price across suppliers, use our checkout to see current options tied to your prescription. We provide transparent selection and keep fees clear so you can plan your budget with your prescriber.

We support US shipping from Canada with licensed dispensing. You can review pricing details at checkout, upload your prescription, and track fulfilment in your account. If you are seeking coupons or seasonal offers, visit our Promotions page. Out-of-pocket costs vary by insurer and by pharmacy workflow.

Availability and Substitutions

Supply can vary by manufacturer, pack size, and country of origin. If supply is limited, your prescriber may recommend an alternative therapy in the same class or a different approach based on your medical history. A true AB-rated Generic Trulance may not be available in all markets; availability changes over time and by jurisdiction.

Patient Suitability and Cost-Saving Tips

Good candidates are adults diagnosed with CIC or IBS-C who do not have a known or suspected bowel obstruction and can follow daily dosing. It may not be suitable for patients under 18 years, those with severe diarrhea, or those at high risk of dehydration. Discuss your full medical history with your prescriber.

To help manage costs, consider multi-month fills if appropriate, since fewer refills can reduce per-fill fees. Align refills with routine appointments so your prescriber can verify continued need without gaps. Set reminders in your account so you do not run out. Store spare tablets correctly to avoid waste.

Questions to Ask Your Clinician

• Diagnosis clarity: CIC or IBS-C, and how that guides therapy
• Goals of therapy: stool frequency, consistency, and symptom targets
• Side-effect plan: what to do if diarrhea or cramping occurs
• Administration options: swallowing whole vs. mixing with applesauce or water
• Duration of use: when to reassess and adjust the plan
• Travel advice: how to store tablets safely while away from home
• Dietary supports: fiber and hydration appropriate for your condition

Authoritative Sources

U.S. Prescribing Information

Health Canada Drug Product Database

Manufacturer Product Page

Drug Education and Digestive Health

Learn more about related conditions and therapies: explore Chronic Constipation, Irritable Bowel Syndrome Ibs, and Gastrointestinal topics. For country-of-origin details, see Canada. You can also read our guides on Dicyclomine Hcl For Ibs Stomach Cramp Management, The Gut Brain Connection Exploring The Link Between Stress And Ibs Symptoms, and Domperidone Uses For Nausea Relief Better Digestive Health.

Ready to proceed? Upload your prescription to Order Trulance online with prompt, express shipping that ships from Canada to US. This information is for educational purposes and does not replace your clinician’s advice.