Verzenio® Tablets for HR+ HER2- Breast Cancer

Abemaciclib is a targeted CDK4/6 inhibitor used with endocrine therapy for certain breast cancers. This page explains indications, dosing basics, safety, and access so treatment planning feels clearer.

Verzenio® can be an important part of care for HR+ HER2- disease. Many visitors compare Verzenio price without insurance and options for US delivery from Canada. Here, you can review guidance, learn about access steps, and see ways to plan refills without surprises.

What Verzenio Is and How It Works

This medicine is a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. It helps slow cancer cell growth by blocking proteins that drive cell-cycle progression. On the label, it is used for HR-positive, HER2-negative advanced or metastatic breast cancer, either with an aromatase inhibitor as initial therapy, with fulvestrant after progression, or as monotherapy in specific previously treated settings. It is also approved as adjuvant therapy for high‑risk, node‑positive early breast cancer with endocrine therapy.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Abemaciclib tablets are taken by mouth and can be used alongside treatments like aromatase inhibitors or fulvestrant, depending on stage and prior therapy. The mechanism and combinations align with official labelling; always follow your prescriber’s instructions and the package insert.

Who It’s For

The Verzenio medication is indicated for adults with HR+ HER2- advanced or metastatic breast cancer. It may be used as first-line therapy with an aromatase inhibitor, or after progression with fulvestrant. It can be used alone after prior endocrine therapy and chemotherapy in specific circumstances. It is also indicated for certain high-risk patients with early breast cancer in combination with ongoing endocrine therapy.

People who are pregnant or may become pregnant should avoid treatment; effective contraception is recommended during therapy and for the period advised on the label. Breastfeeding is not recommended during therapy and for a time after the last dose. Patients with significant liver problems may require adjustments per the label. Those with a history of serious lung inflammation, recurrent blood clots, or uncontrolled diarrhea should discuss risks and monitoring closely with their clinician.

Learn more about the condition context in our resources on HR+ Breast Cancer, Metastatic Breast Cancer, and Early Breast Cancer.

Dosage and Usage

Typical schedules follow the official label. When used with an aromatase inhibitor or with fulvestrant, tablets are commonly taken twice daily. When used alone, tablets are also taken twice daily. Take with or without food, at the same times each day. Swallow whole with water. Do not crush, chew, or split tablets.

Avoid grapefruit or grapefruit juice, as it can affect how the medicine is processed. Alcohol use should be discussed with the prescriber. If stomach upset occurs, administration with a light snack may help maintain consistency. Follow the instructions provided for laboratory monitoring, including blood counts and liver tests.

If nausea or diarrhea occurs, follow the supportive care plan given by your healthcare professional. Do not change the dose on your own. The label provides criteria for any adjustments or pauses; decisions are made by the prescriber according to clinical findings.

For background reading on combination partners, see Fulvestrant Basics and Anastrozole Info.

Strengths and Forms

Film‑coated tablets are supplied in multiple strengths to support label‑based dosing. Commonly available presentations include 50 mg, 100 mg, 150 mg, and 200 mg tablets. Availability by strength may vary by dispensing pharmacy and manufacturer supply. Check the label and your prescription to confirm the intended strength and quantity. In some regimens, different strengths are used when prescribers adjust therapy per clinical response and tolerability.

Many patients and caregivers look up Verzenio 150 mg tablets when reviewing therapy plans. Use only the strength written on the prescription. If your prescription changes, confirm the updated strength and directions with the dispensing pharmacist before starting a new pack.

Missed Dose and Timing

If a dose is missed, skip it and take the next dose at the regularly scheduled time. Do not take an extra dose to make up for the missed one. If vomiting occurs after taking a Verzenio tablet, do not take an extra dose; continue with the next scheduled dose. Keep a simple dosing log or reminder to support consistency day to day.

Storage and Travel Basics

Store tablets at room temperature in the original container, protected from moisture. Keep the container tightly closed and out of reach of children and pets. Do not store in a bathroom or other high‑humidity locations. Retain the pharmacy label and any patient information leaflet with the container.

When you travel, keep the medication in your carry‑on bag with the prescription label attached. Pack only in original packaging and carry a copy of the prescription or a summary from your prescriber, if available. For longer trips, allow extra time for security screening and keep the tablets away from direct heat. If an organizer is used, confirm that the weekly layout matches your schedule to avoid missed doses.

Pen Handling and Sharps Disposal

Not applicable. This therapy is supplied as oral tablets and does not require pen priming, needle changes, or sharps disposal.

Benefits

This treatment works by inhibiting CDK4/6 to slow cell growth in HR+ HER2- breast cancer. It can be used with endocrine therapy, which may support disease control in advanced settings, and it has an adjuvant role for selected early‑stage, high‑risk patients. Oral administration avoids clinic injections and can fit into daily routines. Label‑directed monitoring helps teams manage tolerability over time.

Side Effects and Safety

• Diarrhea, nausea, or decreased appetite
• Fatigue or weakness
• Abdominal pain or mouth sores
• Infections, often related to low white blood cells
• Headache or dizziness
• Elevated liver enzymes on lab testing

Serious side effects can include severe diarrhea with dehydration, neutropenia with infection, liver injury, interstitial lung disease or pneumonitis, and venous thromboembolism. Seek urgent medical attention for chest pain, shortness of breath, severe abdominal pain, signs of infection, or unusual bleeding. Clinicians may order regular blood counts and liver tests. Those using anticoagulants or with clotting history should review risks. Report persistent or worsening symptoms promptly for assessment.

Drug Interactions and Cautions

Strong CYP3A inhibitors or inducers can change abemaciclib levels. Examples include certain antifungals, antibiotics, antivirals, and seizure medicines. Grapefruit and Seville oranges should be avoided. Discuss all prescription drugs, over‑the‑counter medicines, and herbal supplements with a healthcare professional. Dose adjustments, if needed, are determined by the prescriber according to the label. Those with liver impairment require careful review, and regular labs are common.

What to Expect Over Time

Responses vary. Many patients continue therapy with regular clinical follow‑up and lab monitoring. Gastrointestinal effects may occur early and often improve with supportive care and adherence strategies. Blood counts and liver tests guide ongoing safety checks. A simple routine, paired with a medication log or reminders, can support consistent dosing. If the care plan includes combination endocrine therapy, your team will explain the schedule and how monitoring fits into clinic visits.

For background on targeted options in this space, see our Palbociclib Guide. You can also browse our Cancer category or review country details under Canada.

Compare With Alternatives

Other approved options in HR+ HER2- breast cancer include a CDK4/6 inhibitor and a targeted PI3K inhibitor for appropriate tumor profiles. Examples we offer include Ibrance® and Piqray. Selection depends on prior therapy, tumor markers, and clinician guidance. Combinations with endocrine agents such as fulvestrant or an aromatase inhibitor are common and follow label‑directed protocols.

Pricing and Access

Patients often compare the Price of Verzenio, coverage options, and ways to manage out‑of‑pocket costs. With US shipping from Canada, our team helps coordinate fulfillment once the prescription is received and verified. Cash‑pay buyers sometimes ask about the Verzenio cash price versus insured copays; actual totals vary by strength, quantity, and dispensing pharmacy. For general savings tips, check our Promotions page for current offers.

To proceed, place the item in your cart and upload the prescription during checkout. Our process includes prescriber verification before dispensing. We use encrypted checkout to protect personal and payment details.

Availability and Substitutions

Supply can vary by strength and pack size. If a specific tablet strength is temporarily unavailable, a prescriber may recommend an alternative strength or a different therapy within the class. Pharmacists dispense the strength and quantity written on the prescription; any changes require prescriber approval. We do not provide restock dates, but we can keep the order open while your clinician advises on next steps.

Patient Suitability and Cost-Saving Tips

Patients with HR+ HER2- disease who meet label criteria for advanced, metastatic, or high‑risk early settings may be candidates. Those with active infections, uncontrolled diarrhea, or significant liver impairment need careful review before starting. Pregnancy and breastfeeding are not recommended during treatment. All patients should receive guidance on supportive care, lab monitoring, and when to contact the care team.

To help manage ongoing costs, consider multi‑month fills approved by your prescriber, which can reduce per‑fill fees and time. Set refill reminders on your phone or calendar so you can place an order before running low. If your insurance changes during therapy, ask the care team to recheck benefits while you compare Canadian pricing. When planning travel, store your tablets properly and carry documentation for security checks.

Questions to Ask Your Clinician

• Therapy role: where this treatment fits in my overall plan
• Combination partner: which endocrine therapy pairs best
• Monitoring plan: labs and clinic visits recommended
• Side‑effect care: how to manage diarrhea or low counts
• Interactions: medicines, supplements, or foods to avoid
• Refills: timing for renewals and travel planning

Authoritative Sources

US Prescribing Information (Eli Lilly)FDA DailyMed LabelHealth Canada Drug Product Database

Ready to proceed? Add to cart, upload your prescription, and complete checkout with prompt, express shipping. Temperature-controlled handling when required. This content is educational and not a substitute for professional medical advice; always follow your prescriber and the official label.