Viberzi® Tablets for Irritable Bowel Syndrome with Diarrhea

Viberzi is a prescription tablet for adults with irritable bowel syndrome with diarrhea. It helps reduce abdominal pain and frequent loose stools. This page explains how it works, who it may suit, key safety points, and how to access it with US delivery from Canada, including Viberzi® without insurance.

What Viberzi Is and How It Works

Viberzi® contains eluxadoline, a gut-selective agent that acts on opioid receptors in the intestine. It reduces bowel contractions and lowers intestinal secretion, which can improve stool consistency and decrease urgency. The treatment targets IBS-D symptoms while aiming to preserve normal bowel function.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

IBS-D varies by person. Some notice less cramping and fewer urgent trips to the bathroom as the therapy takes effect. Others may need ongoing evaluation to see if this approach fits their pattern of symptoms. Learn more in our Irritable Bowel Syndrome Ibs category and explore related options in Gastrointestinal.

Who It’s For

This medicine is indicated for adults with IBS-D. It is not approved for children. It should not be used in people without a gallbladder due to increased risk of pancreatitis and sphincter of Oddi spasm. It is also contraindicated in those with known or suspected biliary duct obstruction, a history of pancreatitis, structural pancreatic disease, or severe liver impairment.

Avoid use in anyone who drinks more than three alcoholic beverages a day or has alcohol abuse or addiction. It should not be used in individuals with a history of chronic or severe constipation or related complications. Discuss pregnancy or breastfeeding with a healthcare professional, as risks and benefits need careful consideration.

Dosage and Usage

The labeled adult starting dose is 100 mg by mouth twice daily with food. Some people may use 75 mg twice daily if they have mild or moderate hepatic impairment or are taking certain interacting medicines. Swallow the tablets whole with a drink of water. Do not crush or chew.

Take doses with meals at consistent times. If severe constipation or new or worsening abdominal pain occurs, stop taking the treatment and contact the prescriber promptly. Do not exceed the prescribed amount. Follow the official prescribing information for full instructions.

Strengths and Forms

Tablets are available in two strengths: 75 mg and 100 mg. Availability can vary by pharmacy and region.

Missed Dose and Timing

If a dose is missed, take the next dose at the usual time with food. Do not double up to make up for a missed dose. A consistent schedule with meals can support steadier symptom control. If frequent misses occur, consider a reminder system or pill organizer.

Storage and Travel Basics

Store the tablets at room temperature in a dry place, away from excessive heat and moisture. Keep the medicine in the original, child-resistant container, tightly closed. For travel, carry it in a hand luggage compartment with the prescription label visible. Pack enough supply for the entire trip, plus a small buffer in case of unexpected delays.

As a controlled prescription product, carry documentation when passing security checkpoints. Keep medicines out of reach of children and pets. Our partners use temperature-controlled handling when required.

Benefits

As part of IBS-D management, this therapy can reduce abdominal pain, urgency, and episodes of diarrhea. It can improve stool consistency and help stabilize day-to-day bowel patterns. Many appreciate the twice-daily schedule with meals, which can fit into routine breakfast and dinner habits. The treatment focuses on gut receptors and acts locally, which may help limit some whole-body effects.

Side Effects and Safety

• Constipation
• Nausea
• Abdominal pain or discomfort
• Vomiting
• Upper respiratory tract symptoms

Serious risks can include pancreatitis and sphincter of Oddi spasm, which may present as severe abdominal pain, sometimes with nausea and vomiting. The risk is higher in people without a gallbladder, which is why use in those patients is not recommended. Severe constipation can also occur. Rare allergic reactions are possible. Seek urgent care if severe pain, jaundice, or signs of pancreatitis develop. Read the Medication Guide and full Prescribing Information for complete safety details.

Drug Interactions and Cautions

Eluxadoline exposure can increase with strong OATP1B1 inhibitors such as cyclosporine or gemfibrozil; prescribers may adjust selection accordingly. Combining with other medicines that cause constipation, including some anticholinergics or opioids, can raise the risk of severe constipation. Avoid regular alcohol intake above three drinks per day. In severe hepatic impairment, the treatment is contraindicated. Always share a full medication list, including OTC products and supplements, with a clinician.

What to Expect Over Time

Symptom patterns may fluctuate. Some people observe fewer urgent stools and less cramping after starting therapy, while others need time and follow-up to assess response. Keeping a brief symptom diary can help track bowel movements, pain levels, and meal timing. If constipation becomes persistent or severe, the prescriber may advise stopping the medicine. Continued review with a healthcare professional helps align expectations and adjust the overall IBS-D plan.

For background on the brain–gut axis and stress, see our article on the Gut Brain Connection.

Compare With Alternatives

Antispasmodics can help some adults with IBS-related cramping. A common option is Dicyclomine Hcl, which reduces intestinal muscle spasms. Another option in some markets is Trimebutine, used for functional GI disorders. Learn more about antispasmodics in our overview Dicyclomine Hcl For Ibs.

Compare Viberzi prices thoughtfully with these approaches and with non-prescription strategies recommended by a healthcare professional. Suitability depends on symptom pattern, medical history, and risk factors.

Pricing and Access

We list current options with Canadian pricing and transparent details so you can plan. For those reviewing Eluxadoline tablets price, compare per-tablet values and refill intervals to see how multi-month supplies may fit your budget.

Orders Ships from Canada to US with a valid prescription. Checkout is simple, and our site uses secure processes. If a coupon is part of your plan, visit our Promotions page for current notices.

Savings CTA: Explore potential savings compared with typical local cash-pay approaches. Pricing CTA: View available quantities and add to cart when you are ready.

For country-specific listings, see Canada.

Availability and Substitutions

Supply can vary. If the tablets are unavailable, a prescriber may recommend an alternative based on your clinical profile and history. Some patients also look for a Viberzi coupon through manufacturer or third-party programs; availability and eligibility change over time. No restock dates are guaranteed. Your prescriber and pharmacist can guide safe substitutions when appropriate.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults with IBS-D who have an intact gallbladder, lower alcohol intake, and no history of pancreatitis or severe constipation. It is not for people with severe liver impairment or those exceeding three alcoholic drinks daily. Clinicians weigh benefits and risks before prescribing this therapy.

Cost-saving ideas include longer refill intervals to reduce per-fill fees, comparing quantities, and aligning refills with pay periods. Many patients review the Viberzi cash price alongside other therapies to plan budgets. Refill reminders help avoid gaps that can disrupt symptom control. If traveling, request enough tablets in advance and keep a copy of the prescription with the medicine.

Questions to Ask Your Clinician

• Fit for symptoms: Does eluxadoline match my IBS-D pattern?
• Safety factors: Do my gallbladder and liver history affect suitability?
• Interactions: Are any of my current medicines a concern?
• Alcohol use: What intake level is safe with this therapy?
• Constipation plan: What steps should I take if stools become infrequent?
• Monitoring: Which signs suggest I should stop and seek care?
• Alternatives: When might antispasmodics or other options be considered?

Authoritative Sources

FDA Prescribing Information

Manufacturer Full Prescribing Information

For additional IBS resources, see Pentasa Medication for context on digestive treatments.

Buy Viberzi online from Borderfreehealth with US shipping from Canada and prompt, express shipping. This overview is educational and not a substitute for approved labeling or professional guidance.