Vyzulta Ophthalmic Solution (Latanoprostene Bunod)

Vyzulta Ophthalmic Solution is a prescription eye drop used to help lower intraocular pressure (eye pressure) in certain eye conditions. This page explains how it works, who it’s for, dosing basics, and what to know about storage and safety. It also outlines access steps for people paying cash without insurance through our prescription referral model.

What Vyzulta Ophthalmic Solution Is and How It Works

This medicine is supplied through a cross-border pharmacy network that Ships from Canada to US when a valid prescription is on file. Prescriptions are verified with the original prescriber before partner dispensing. The active ingredient, latanoprostene bunod, is a prostaglandin analog (a glaucoma drug class that increases fluid outflow) that also releases nitric oxide (a signaling molecule) in eye tissues.

In open-angle glaucoma and ocular hypertension, eye fluid may not drain efficiently, which can raise pressure and harm the optic nerve over time. Latanoprostene bunod can increase outflow through more than one pathway, including the uveoscleral route and the trabecular meshwork (the eye’s main drainage tissue). What Is Glaucoma is a helpful primer if these terms are new.

Why it matters: Lowering eye pressure is a key step in protecting long-term vision.

Who It’s For

This treatment is generally used for adults with elevated eye pressure related to glaucoma or ocular hypertension. People often land on these terms after a screening exam or an eye specialist visit, where pressure readings and optic nerve findings guide next steps. For condition-specific browsing, see the hubs for Open Angle Glaucoma and Ocular Hypertension, or explore other therapies within Ophthalmology.

At a high level, it should not be used by anyone with a known allergy to latanoprostene bunod or any ingredient in the bottle. Extra caution may be needed in people with certain eye histories, such as prior macular edema (swelling in the retina), active intraocular inflammation (uveitis), or a history of herpetic eye disease, since medicines in this class can sometimes worsen underlying inflammation. A prescriber may also consider lens status after cataract surgery and other retinal risk factors when selecting therapy.

Dosage and Usage

Typical label-based dosing is one drop in the affected eye(s) once daily in the evening. Using it more often than prescribed may reduce the pressure-lowering effect for some prostaglandin-class drops. If multiple glaucoma medicines are used, the prescriber usually sets a schedule that fits the full regimen and the person’s eye exam findings.

To reduce contamination risk, wash hands, avoid touching the tip to the eye or skin, and recap promptly. When Vyzulta Ophthalmic Solution is used alongside other eye drops, doses are commonly separated by at least 5 minutes so each product has time to remain on the eye surface. Contact lens wearers are often told to remove lenses before dosing and wait about 15 minutes before reinserting, because some ophthalmic preservatives can be absorbed by soft lenses.

Quick tip: Keep a simple checklist for nighttime drops and refills.

Strengths and Forms

This medication is an ophthalmic solution (liquid eye drop) used from a multi-dose bottle. It is commonly supplied as a 0.024% formulation, and availability can vary by pharmacy partner and current sourcing. Dispensing is handled through licensed Canadian partner pharmacies in our network.

Strength and presentation details should always be confirmed on the carton and the pharmacy label. If anything looks different than expected—such as the solution appearance, the labeling, or the cap integrity—use the pharmacy-provided contact channel for clarification before starting.

Vyzulta Ophthalmic Solution may be one part of a broader glaucoma plan that also includes follow-up pressure checks and visual field testing.

Storage and Travel Basics

Storage instructions matter for eye drops because heat, light, and contamination can reduce product quality. Follow the specific carton labeling for the bottle you receive. For this medication, labeling commonly directs refrigeration for unopened bottles and allows controlled room-temperature storage after opening, with limits on how long an opened bottle should be kept.

For travel, keep the bottle in its original carton when possible and avoid leaving it in a hot car or near freezing temperatures. A small insulated pouch can help during longer trips, especially in warm climates. If a bottle was exposed to extreme temperatures, cloudiness, or leaks, the safest step is to confirm next actions with the dispensing pharmacy and the prescriber rather than trying to “test” the drop.

Side Effects and Safety

Most side effects involve the treated eye and surrounding tissues. Common effects can include eye redness, mild burning or stinging after instillation, watery eyes, itchiness, or brief blurred vision. Changes around the eye can also occur with prostaglandin-class drops, such as eyelash growth or darkening and gradual increased pigmentation of the iris or eyelid skin; these may be more noticeable with long-term use.

More serious effects are less common but important to recognize. Stop and seek urgent assessment for severe eye pain, sudden vision changes, signs of an eye infection, significant swelling, or symptoms of an allergic reaction. People with certain retinal risk factors may be monitored for macular edema, and those with a history of uveitis may need closer follow-up. If new or persistent visual symptoms occur while using Vyzulta Ophthalmic Solution, it should be discussed promptly with an eye-care professional. For general context on age-related visual symptoms, see Vision Changes With Age.

• Local irritation: burning, dryness, itching
• Appearance changes: eyelash or iris darkening
• Vision effects: transient blur after dosing
• Serious concerns: infection signs, marked pain, swelling

Drug Interactions and Cautions

Systemic drug interactions are not a major feature of most topical glaucoma drops, but regimen overlap matters. Using more than one prostaglandin analog at the same time is generally avoided unless a prescriber directs it, because it may not improve control and could complicate side effects. If other prescription eye drops are used, spacing doses helps reduce washout and confusion about timing.

Share a complete medication list with the prescriber, including non-prescription eye drops, ointments, and contact-lens solutions. Pregnancy and breastfeeding considerations should be discussed with a clinician, since risk/benefit decisions are individualized. Anyone with recent eye surgery, active eye inflammation, or a history of certain retinal conditions may need tailored monitoring while on therapy.

Compare With Alternatives

For many people, a prostaglandin-class drop is a first-line option because it is usually dosed once daily. Alternatives within the same class include Latanoprost and Lumigan (bimatoprost). Other options may work through different mechanisms, such as beta-blockers (for example, timolol), carbonic anhydrase inhibitors (for example, dorzolamide or brinzolamide), alpha-agonists (for example, brimonidine), or combination drops that merge two medicines in one bottle.

Choice depends on the pressure target, eye-surface tolerance, dosing complexity, and other health factors. Some people need combination therapy over time, and others switch due to redness, dryness, or preservative sensitivity. If a current regimen is hard to tolerate, a structured review of alternatives with an eye specialist can help; a general overview is available in Alternatives To Combigan, which discusses how combination drops fit into care planning.

Pricing and Access

Out-of-pocket pricing for prescription eye drops can vary based on dose supply, refill frequency, and pharmacy dispensing fees, and it may change over time. For people using a cash-pay approach, access can depend on whether a prescriber allows refills and whether a therapeutic substitute is acceptable when sourcing shifts. Cash-pay access can help when someone is without insurance.

As a prescription referral platform, we coordinate documentation and route fulfillment through partner pharmacies with US delivery from Canada when permitted and appropriate. Vyzulta Ophthalmic Solution requests require a valid prescription, and refills are released only when authorized by the prescriber’s directions. For optional savings opportunities, see Current Promotions (availability varies and terms apply).

Authoritative Sources

For the most reliable details on indications, warnings, and handling, the official prescribing information should be the first reference. Clinical decisions also rely on eye exam findings such as optic nerve appearance, visual field testing, and measured eye pressure over time. If a label detail seems unclear, a pharmacist or eye-care professional can interpret it in the context of the full medication list and medical history.

These references provide regulator- and clinician-oriented summaries:

• Read the FDA prescribing information for full details: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208144s000lbl.pdf
• Overview of glaucoma from the American Academy of Ophthalmology: https://www.aao.org/eye-health/diseases/glaucoma

For site actions, prescriptions and refills can be submitted online with prompt, express shipping when available.

This content is for informational purposes only and is not a substitute for professional medical advice.