Xeljanz® Tablets for Rheumatoid Arthritis

Xeljanz® is an oral Janus kinase (JAK) inhibitor used for immune-mediated conditions. It treats adults with rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis when other therapies are not enough. You can access US delivery from Canada and see options if you need Xeljanz without insurance.

What Xeljanz Is and How It Works

This medicine contains tofacitinib, which helps calm overactive immune signaling. It targets JAK pathways inside cells to reduce inflammation that drives joint pain, swelling, and gut symptoms. Effects are dose- and indication-dependent, following the official label.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

As a small-molecule therapy taken by mouth, the treatment offers an alternative to injectable biologics. It can be used alone or with certain conventional disease-modifying drugs, as directed by your prescriber. Safety monitoring is important because this class can affect blood counts, infection risk, and lipids.

Who It’s For

This therapy is approved for adults with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. It is also used for active psoriatic arthritis in adults who did not respond well to prior medicines. For ulcerative colitis, it is indicated for adults with moderate to severe disease, according to label criteria.

Some people should not take it. Those with severe active infections, very low blood counts, or known hypersensitivity must avoid it. Your healthcare professional will review past clots, heart issues, and cancer history, because these risks are part of the boxed warnings.

If your prescriber recommends access through a Canadian mail-order pharmacy, you can buy tofacitinib from Canada through Border Free Health. For condition details, see our Rheumatoid Arthritis and Ulcerative Colitis pages.

Dosage and Usage

Follow the exact schedule on your prescription label. For arthritis, tofacitinib is generally taken regularly either twice daily for the immediate-release option or once daily for the extended-release option. For ulcerative colitis, dosing differs between induction and maintenance phases. Your prescriber will choose the lowest effective regimen and adjust based on response and safety labs.

Swallow tablets whole with water. You may take them with or without food. If you are prescribed an extended-release tablet, do not split, crush, or chew it. Keep consistent timing day to day to support steady exposure. Regular blood work and infection screening are part of care with this class.

Do not combine this medicine with biologic disease-modifying therapies or potent immunosuppressants unless explicitly directed by your clinician. Always review the full prescribing information for indication-specific dosing and safety requirements.

Strengths and Forms

This treatment is available as immediate-release tablets and extended-release tablets. Commonly published strengths include 5 mg and 10 mg immediate-release, and 11 mg extended-release. Availability may vary by market and manufacturer. Your pharmacy listing reflects currently stocked presentations.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember that day. If it is nearly time for your next dose, skip the missed dose and resume your regular schedule. Do not double up. For extended-release tablets, avoid taking more than the prescribed once-daily amount. If multiple doses are missed, contact your prescriber for guidance.

Storage and Travel Basics

Store tablets at room temperature in the original, tightly closed container. Protect from excess moisture. Keep out of reach of children and pets. When traveling, carry your medicine in your hand luggage with a copy of your prescription. Use a simple pill organizer only if it keeps tablets dry and secure. Do not use medication that is expired or damaged.

For extended trips, plan refills in advance to avoid gaps in therapy. Border Free Health supports encrypted checkout and can coordinate your refill schedule with your prescriber when appropriate.

Benefits

This therapy can reduce signs and symptoms of rheumatoid and psoriatic arthritis and improve physical function. In ulcerative colitis, it may help induce and maintain remission in appropriate adults. The oral route offers day-to-day convenience for people who prefer tablets over injections. Using a targeted mechanism, this medicine works systemically to address inflammation at its source.

Side Effects and Safety

Common effects can include headache, upper respiratory tract infections, nasopharyngitis, diarrhea, nausea, and increased cholesterol on labs. Some people notice mild stomach upset or fatigue.

• Respiratory symptoms: cough, runny nose, sore throat
• Gastrointestinal changes: nausea or loose stools
• Headache or dizziness: usually transient
• Lab changes: lipids or liver enzymes may shift

Serious risks include severe infections, opportunistic infections, malignancies, major adverse cardiovascular events, thrombosis, and mortality observed in certain higher-risk populations with the class. Gastrointestinal perforation has been reported. Your clinician will screen for tuberculosis, update vaccines, and monitor blood counts and lipids. Seek urgent care for chest pain, sudden shortness of breath, unilateral leg swelling, high fever, or persistent severe abdominal pain.

Drug Interactions and Cautions

Tell your healthcare professional about all medicines and supplements. Strong CYP3A4 inducers may lower exposure. Strong CYP3A4 inhibitors or combined moderate CYP3A4 and strong CYP2C19 inhibitors may raise levels and require adjustments per label. Avoid live vaccines during treatment. Do not use with biologic DMARDs or potent immunosuppressants unless your prescriber directs otherwise. People with chronic or recurrent infections, a history of clots, or certain cancers need individualized risk assessment.

What to Expect Over Time

Some people notice gradual symptom relief as therapy is continued. Your prescriber will assess joint symptoms, mobility, or bowel symptoms over follow-up visits. Blood tests help confirm safety while you stay on treatment. Adherence matters, so try to take doses at the same times daily.

For budgeting your long-term plan, check Xeljanz price updates on this page. Your clinician can help align treatment goals with monitoring and supportive care so therapy remains as safe as possible for you.

Compare With Alternatives

Depending on your diagnosis and history, a biologic or another oral option may be considered. For an injectable anti-TNF option often used in arthritis and colitis, review Humira Prefilled Syringe. For an oral therapy frequently used in psoriatic disease, see Otezla. Your prescriber will compare mechanisms, monitoring, and risks to select the right plan.

Pricing and Access

We list Xeljanz Canadian pricing so you can see current options for your prescription. This helps you compare Canadian-sourced tablets with US shipping from Canada. Review the product page for cash-pay details and any supply notes. If you are looking for deals, visit our Promotions page for current site-wide offers; availability can change.

Many patients ask about the monthly Xeljanz cost and ways to lower out-of-pocket spend. Savings vary by strength, quantity, and manufacturer source. If you plan multi-month fills, ask your prescriber to write for a suitable day supply to reduce per-fill fees where allowed.

Availability and Substitutions

Supply can vary by strength and pack size. If a specific presentation is not available, your prescriber may recommend an alternative formulation or a different therapy in the same category. If you have a coupon from a manufacturer program, note that use with international mail-order may be restricted, but we note “Xeljanz coupon” language here so you can discuss options with your clinician or insurer.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults who need an oral option and regular lab monitoring. It may not be appropriate for those with active serious infections, very low lymphocyte counts, or recent blood clots. People with significant cardiovascular risk factors require careful evaluation of benefits and risks.

• Multi-month fills: can reduce per-order fees
• Refill reminders: help prevent gaps in therapy
• Prescriber notes: allow flexible quantity for travel
• Coverage check: confirm benefits before changing therapy

To plan for expenses, compare tofacitinib Canadian pricing with domestic options and discuss pharmacy coordination with your care team. Your out-of-pocket cost may vary based on dose, quantity, and dispensing pharmacy. If you have questions about affordability, ask your prescriber about alternatives that fit your clinical and financial needs. For broader reading on immune conditions, see our Immunology hub and this overview on Autoimmune Diseases.

Questions to Ask Your Clinician

• My diagnosis fit: is this class right for my condition?
• Safety plan: what labs and screening do I need before and during therapy?
• Risk profile: how do clots, infections, or heart risks apply to me?
• Concomitant meds: which drugs or supplements should I avoid?
• Pregnancy plans: what are the recommendations if I am pregnant or breastfeeding?
• Vaccination: which vaccines should I receive before starting?
• Affordability: which pharmacy option best fits my budget and travel plans?

Authoritative Sources

Manufacturer Product Page

FDA DailyMed Prescribing Information

Health Canada Drug Product Database

Ready to proceed? Place your order now for prompt, express shipping that ships from Canada to US, with temperature-controlled handling when required. This content is for general information and does not replace your prescriber’s advice.