Xospata® Tablets for FLT3-Mutated AML

What Xospata Is and How It Works

Xospata® is an oral targeted therapy for adults with certain types of acute myeloid leukemia. It contains gilteritinib, a FLT3 inhibitor that helps block signals driving leukemia cell growth. You can review gilteritinib price without insurance alongside options with US delivery from Canada. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine inhibits mutant FLT3 receptor signaling inside leukemia cells. By dampening downstream pathways, it may slow proliferation and support recovery of normal blood counts. It is taken by mouth once daily and can be used outside the hospital setting, with close monitoring by your oncology team. Refer to the official resources below for comprehensive details.

Learn about AML basics and related care on our Acute Myeloid Leukemia and Cancer pages. For cross-therapy context, see our article on Dasatinib Mechanism.

Who It’s For

This treatment is indicated for adults with relapsed or refractory AML that tests positive for a FLT3 mutation using an FDA-cleared test. The gilteritinib approval supports use after prior therapy when disease persists or returns. People who are pregnant or planning to become pregnant should discuss risks, as fetal harm can occur. Breastfeeding is not recommended during treatment and for a period after the last dose, per the official label.

It may not be appropriate for those with certain heart rhythm problems, severe liver issues, or a history of specific neurologic conditions. Your clinician will weigh benefits and risks, review labs, and coordinate ECG monitoring when needed.

Dosage and Usage

The usual recommended dose is 120 mg taken once daily at about the same time each day. Swallow tablets whole with water. You may take it with or without food. Do not crush or split tablets. Your care team will monitor blood counts, liver tests, and may perform periodic ECGs. If you develop concerning symptoms, contact your oncology team promptly.

Some medicines and supplements can affect exposure. Your prescriber may adjust plans if strong CYP3A inducers or inhibitors are necessary. Avoid starting or stopping other therapies without guidance. For complete directions, consult the gilteritinib label and follow your clinician’s instructions.

Strengths and Forms

This therapy is available as film-coated tablets in a commonly used strength of 40 mg. Packaging and availability can vary by manufacturer lot and region. Your prescription will specify the quantity required for your regimen.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember on the same day. If the next dose is due soon, skip the missed dose and resume your normal schedule. Do not take two doses within a 12-hour window. If you vomit after a dose, do not take an extra tablet. Keep a daily reminder to help maintain consistency.

Storage and Travel Basics

Store tablets at room temperature in the original container with the cap tightly closed. Protect from moisture and keep out of reach of children and pets. Use a pill organizer only if advised, since original packaging often protects from humidity.

When traveling, carry this medicine in your hand luggage with your prescription label. Keep a copy of your oncology clinic’s contact details. Plan dosing around time zones to maintain a consistent daily schedule. If your trip involves security checks, keep medications in labeled containers to avoid delays. Use child-resistant storage during family visits or hotel stays. For sensitive medicines, our partners use temperature-controlled handling when required.

Benefits

This FLT3 inhibitor targets a key driver of malignant cell growth in FLT3-mutated AML. Taking it orally may reduce clinic visits compared with some infusions. Your care team can monitor labs and ECGs while you continue daily dosing at home. The treatment can be used as a single agent, allowing flexible scheduling and supportive care as needed.

Many patients appreciate the simplicity of a once-daily schedule. Your clinician will track response with blood work and imaging or marrow assessments, and adjust your overall care plan as appropriate.

Side Effects and Safety

• Fatigue or tiredness
• Nausea, vomiting, or diarrhea
• Constipation or abdominal discomfort
• Joint or muscle pain
• Headache or dizziness
• Cough or shortness of breath
• Swelling in hands or legs
• Abnormal liver tests
• Rash or skin changes

Serious risks can occur. Differentiation syndrome is a medical emergency and can be life-threatening; seek urgent care for new fever, cough, dyspnea, rapid weight gain, swelling, or low blood pressure. This medicine can prolong the QT interval and may affect heart rhythm. Posterior reversible encephalopathy syndrome has been reported. Pancreatitis and severe liver problems can occur. Tell your clinician about all symptoms, including visual changes, severe headache, chest pain, or palpitations. Review the Xospata FDA label for full safety details and boxed warnings.

Drug Interactions and Cautions

Strong CYP3A inhibitors or inducers can change blood levels of this therapy. St. John’s wort and certain seizure medicines are notable inducers. Some antibiotics, antifungals, and antivirals are inhibitors. Grapefruit or grapefruit juice may also interact. This treatment can affect the ECG, so combining with other QT-prolonging drugs requires caution and monitoring.

Always provide a full list of prescription drugs, over-the-counter products, and supplements to your prescriber. Avoid starting or stopping anything new without professional guidance. Read the Xospata prescribing information and follow your oncology team’s advice on monitoring and precautions.

What to Expect Over Time

Your care team will assess blood counts, organ function, and potential side effects through regular checks. Some people feel tired during the first weeks, and gastrointestinal effects can occur. Response assessments may include marrow exams, which your clinician schedules. If you tolerate therapy and benefit, treatment may continue as directed by your prescriber. If disease progresses or adverse events become significant, your team will discuss next steps.

Keeping a symptom diary and using reminders for daily dosing can help you and your clinician track patterns and coordinate supportive care.

Compare With Alternatives

Treatment plans for AML are individualized. Some patients receive standard chemotherapy, such as Doxorubicin, in combination regimens when appropriate. Others may need supportive oncology care to maintain counts after intensive treatments, such as Nypozi® Prefilled Syringe if prescribed. These options are not substitutes for targeted FLT3 inhibition, but they may appear in comprehensive AML care plans depending on goals and clinical status.

For broader context on therapy classes and care coordination, see our article on Online Prescriptions.

Pricing and Access

You can explore Xospata 40 mg tablets price and compare options for your prescription. We also provide information on Xospata cash price to help you plan discussions with your care team. Our checkout is encrypted, and our team coordinates with partner pharmacies on safe fulfilment. Canadian pricing is reflected on our site, and orders are processed with careful oversight. Ships from Canada to US for eligible prescriptions and addresses.

Category pages like Canada can help you browse medications sourced from Canadian pharmacies.

Availability and Substitutions

Supply can vary by lot and manufacturer. If a strength or package is unavailable, your prescriber may recommend an alternative plan or supportive therapy. Our pharmacists will coordinate with your clinic if substitutions are necessary, consistent with your prescription and local regulations. We do not quote restock dates, but we will share current availability when you start your order.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults whose AML has a confirmed FLT3 mutation and has relapsed or not responded to prior therapy. People with specific heart rhythm issues, uncontrolled electrolyte abnormalities, or severe hepatic problems may need additional monitoring or a different approach. Your oncology team will determine the safest plan.

• Multi-month fills: if approved, reduce refill errands and potential gaps.
• Set reminders: maintain a steady once-daily schedule.
• Travel prep: carry a copy of your prescription and clinic contacts.
• Avoid interactions: share supplement use and new prescriptions early.
• Manage side effects: report symptoms promptly for timely support.

For supportive insights, see our overview on Prescription vs OTC resources.

Questions to Ask Your Clinician

• Is my AML confirmed to have a FLT3 mutation?
• How will you monitor for differentiation syndrome and QT changes?
• What signs should prompt urgent evaluation between visits?
• Which other medicines or supplements should I avoid?
• How will labs and ECGs be scheduled during treatment?
• What supportive therapies might I need during therapy?
• If I travel, how should I manage dosing and documentation?

Authoritative Sources

Astellas Product Page

FDA Prescribing Information

Health Canada DPD

Ready to start? Begin your order with US shipping from Canada and prompt, express shipping. Prescription required. This information is not medical advice; always follow your clinician’s guidance.