Xultophy® Prefilled Pen for Type 2 Diabetes

Xultophy® is a once-daily injection for adults managing type 2 diabetes. This page explains how the combination works, who it suits, and how to use it. You can access Xultophy Prefilled Pen without insurance with US delivery from Canada.

What Xultophy Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine combines insulin degludec with liraglutide, pairing steady basal insulin with a GLP-1 receptor agonist. The insulin supports all-day glucose control, while the GLP-1 component helps reduce post-meal spikes and may curb appetite. Together, the treatment can simplify a multi-drug routine into one daily pen.

The class is sometimes called an IDegLira prefilled pen. It is used along with diet, activity, and regular monitoring. For background on the condition, see Type 2 Diabetes and our overview of insulin options in Different Types Of Insulin.

Who It’s For

This treatment is for adults with type 2 diabetes when a single agent is not enough. It may be considered when fasting glucose remains high on basal insulin or when a GLP-1 alone has not met goals. It is not for people with type 1 diabetes or for treating diabetic ketoacidosis. Children and adolescents are generally not candidates based on current labeling.

People with a personal or family history of medullary thyroid carcinoma or MEN 2 should avoid liraglutide-containing products. Those with prior pancreatitis, gallbladder disease, or severe gastrointestinal disease need careful evaluation. Kidney concerns, dehydration risk, or frequent hypoglycemia also warrant discussion with a healthcare professional.

Dosage and Usage

This therapy is injected subcutaneously once daily, at about the same time each day. It can be taken with or without food. Your prescriber will select a starting dose and adjust over time using fasting glucose data. Titration is gradual and follows the official label. Never share pens, and use a new needle for each injection.

Common injection sites include the abdomen, thigh, or upper arm. Rotate sites to reduce skin reactions. Do not mix with other insulins. If you currently use separate basal insulin and a GLP-1, your clinician will provide a transition plan. For exact steps and limits on maximum daily dosing, follow the package insert and your prescriber’s guidance. Strength details for this combination are in the section below.

Strengths and Forms

The combination is supplied as a prefilled, multi-dose pen. The formulation contains insulin degludec 100 units/mL and liraglutide 3.6 mg/mL in a 3 mL device. Availability may vary by pharmacy partner and by region. Your prescriber will determine the appropriate pen quantity based on your dose and refill cadence.

Some patients recognize the presentation as Xultophy 100/3.6 pen 3 mL. If the exact presentation is not available, your prescriber may suggest a therapeutically appropriate alternative.

Missed Dose and Timing

If you forget a dose, take it when remembered on the same day. Then resume your usual schedule the next day. If an entire day is missed, skip the forgotten dose and continue with your regular plan. Do not double up to make up for a missed injection. For questions after multiple missed doses or if glucose readings change significantly, contact your prescribing clinic.

Storage and Travel Basics

Unopened pens are typically stored refrigerated per label. Do not freeze. Once in use, most pens can be kept at room temperature for a limited number of days; keep away from excessive heat and direct light. Always check the package insert for the exact in-use time window and temperature range, and discard the pen when that period ends even if medicine remains.

When traveling, keep the pen and needles in your carry-on, with a copy of your prescription. Use a travel case to protect from temperature extremes. Inspect the solution before use and do not inject if it looks cloudy, discolored, or contains particles. A neutral safety cue for sensitive items: temperature-controlled handling when required.

Pen Handling and Sharps Disposal

Review the patient instructions for the specific pen model before use. Prime per label if required. Attach a new, sterile needle for each injection. Clean the skin, insert the needle subcutaneously, and inject the full dose. Count slowly per the instructions before removing the needle to ensure complete delivery. Remove the needle after each dose and do not store the pen with a needle attached.

Dispose of used needles in an FDA-cleared sharps container or a heavy-duty household container with a tight-fitting, puncture-resistant lid. Follow local rules for sharps disposal. Keep all supplies out of reach of children and pets.

Benefits

This combination may reduce the number of separate injections. The basal component provides steady, long-acting support for fasting glucose. The incretin component can help blunt mealtime spikes and may reduce appetite. Many people appreciate a single daily schedule and a unified titration plan. Your clinician may also find it useful when simplifying complex regimens.

For educational context, see Lantus Insulin and Levemir Vs Tresiba articles, which outline basal insulin principles relevant to this class.

Side Effects and Safety

• Digestive symptoms: nausea, vomiting, diarrhea, or constipation
• Decreased appetite or early fullness
• Injection-site redness or discomfort
• Headache or fatigue

Serious effects can occur but are less common. These include pancreatitis, gallbladder issues, severe allergic reactions, kidney problems from dehydration, or changes in mood. Low blood sugar can happen, especially if used with sulfonylureas or other insulins. Seek urgent care for signs of severe abdominal pain, neck swelling, trouble breathing, or confusion. Tell your prescriber about thyroid lumps, a history of MEN 2, or prior pancreatitis.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements. Combining with another GLP-1 receptor agonist is not recommended. Insulin and sulfonylureas increase hypoglycemia risk when used together; monitoring may be needed. Thiazolidinediones can cause fluid retention. Steroids, certain antipsychotics, and some antivirals may affect glucose control. Alcohol can raise or lower glucose unpredictably. Beta blockers may mask low blood sugar symptoms. Review the full label and consult your prescriber before making any changes.

What to Expect Over Time

Early on, you and your clinician will focus on fasting glucose and adjust the dose gradually. Digestive symptoms, if present, often lessen after the first weeks. Many people find a consistent daily routine supports steadier readings. Keep a simple log of doses and fasting values, and bring it to appointments. Expect that your plan may evolve with lifestyle, other conditions, or seasonal changes. Consistency, site rotation, and meter checks can make titration smoother.

Compare With Alternatives

Alternatives include using a basal insulin with a separate GLP-1 injection, or switching to an oral agent if suitable. Examples include long-acting insulin paired with weekly GLP-1 therapy, or a DPP-4 inhibitor for those who cannot tolerate GLP-1s. One option we carry is Sitagliptin. Educational reads that may help with decision-making include Trulicity Weight Loss and Insulin Resistance.

Pricing and Access

Canadian pharmacy pricing can be different from U.S. cash rates. To compare options, review our Diabetes Care selection and check today’s availability. If you prefer a straightforward purchase flow, you can Buy Xultophy Prefilled Pen after your prescription is validated. For budget planning, see our article library and learn about Insulin degludec liraglutide pen price trends in context.

We provide US delivery from Canada, with transparent checkout steps and clear next actions after verification. If you’re watching for seasonal offers, visit Promotions for current notices. For broader reading on metabolic care and weight, browse Weight Management resources.

Availability and Substitutions

Supply can vary. If the exact device or pack size is temporarily unavailable, a prescriber may recommend an appropriate alternative from the same class or a different regimen. If you are looking for convenience, some patients search for Order insulin degludec liraglutide pen when discussing backup plans with their clinic. Your prescriber’s guidance should direct any switch.

Patient Suitability and Cost-Saving Tips

Good candidates are adults with type 2 diabetes who need basal support and an incretin effect in one pen. It may not suit people with recurrent severe hypoglycemia, severe gastrointestinal disease, or a history of certain thyroid tumors. Inform your clinician about all conditions, current insulin dose, and any GLP-1 experience before starting.

• Multi-month fills: request longer supplies if appropriate
• Refill reminders: set calendar alerts to avoid gaps
• Meter sync: bring fasting logs to visits
• Travel prep: pack spares and documentation
• Lifestyle support: align meal timing and activity plans

For country details, see Canada. For insulin education, review Fiasp Insulin and broader questions like Can Type 2 Diabetes Be Reversed.

Questions to Ask Your Clinician

• Is this combination appropriate for my current A1C and fasting readings?
• How will we titrate, and what fasting targets should guide adjustments?
• What signs of low blood sugar should I watch for with my other medicines?
• If I miss a dose, when should I resume and when should I call the clinic?
• How long can an opened pen be used, and what temperature limits apply?
• What are the main red flags for pancreatitis or gallbladder issues?
• How should I handle sick days or upcoming travel with this pen?

Authoritative Sources

Novo Nordisk

FDA DailyMed

Health Canada DPD

Ready to proceed? You can place your order with prompt, express shipping and US delivery from Canada. Always use as directed by your prescriber. This page is educational and not a substitute for professional medical advice.