Afinitor® Tablets for Certain Cancers

Afinitor® is an oral everolimus medicine used for several advanced cancers. This page covers indications, dosing basics, safety, and access details with US delivery from Canada. Many patients also compare options for Afinitor without insurance.

What Afinitor Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine contains everolimus, a targeted inhibitor of the mTOR pathway. By dampening cellular growth signals and blood vessel formation in tumors, it may slow disease progression in select settings. The Afinitor drug class is known as mTOR inhibitors, distinct from chemotherapy. For a deeper overview of clinical uses, see Afinitor Uses.

It can be taken alone or with certain endocrine therapies in breast cancer, depending on the regimen. Treatment decisions are individualized by the prescriber based on diagnosis, prior therapies, and overall health.

Who It’s For

Labelled uses include progressive, well-differentiated nonfunctional neuroendocrine tumors of pancreatic origin, gastrointestinal tract, or lung; advanced renal cell carcinoma after certain prior treatments; and renal angiomyolipoma associated with tuberous sclerosis complex when surgery is not needed immediately. In hormone receptor–positive, HER2-negative advanced breast cancer, it may be used with an aromatase inhibitor in appropriate patients. Explore related conditions: Breast Cancer, Kidney Cancer, Pancreatic Neuroendocrine Tumor, and Tuberous Sclerosis.

Everolimus treatment is not suitable for pregnancy. People with significant hepatic impairment, active serious infections, or known hypersensitivity should be evaluated carefully. Vaccination plans, surgical timing, and drug interaction risks should be reviewed with a healthcare professional.

Dosage and Usage

Afinitor is taken once daily at about the same time. Everolimus tablets should be swallowed whole with water, consistently with or without food. Do not crush, chew, or split. Take it the same way each day to keep exposure steady.

Grapefruit or grapefruit juice can change blood levels and should be avoided. Prescribers often monitor mouth sores and infections early in therapy; supportive mouth care is commonly recommended. For breast cancer regimens, it may be paired with endocrine therapy per the plan of care. See background on endocrine partners in Fulvestrant Injection and What Is Anastrozole.

Dose adjustments, if needed, are determined by the prescriber for side effects, hepatic function, or interacting drugs. The official label provides complete instructions that guide clinical decisions.

Strengths and Forms

Film-coated tablets are supplied in commonly referenced strengths such as 2.5 mg, 5 mg, 7.5 mg, and 10 mg. Availability may vary by partner pharmacy and timing. Everolimus tablets 10 mg are one of the typical presentations used in oncology settings. Packaging is designed to protect the product from moisture and light.

Missed Dose and Timing

If a dose is missed, general guidance is to take it when remembered unless it is close to the next scheduled time. If it is nearly time for the next dose, skip the missed dose and resume the regular schedule. Do not take extra doses. Because recommendations can vary by situation, follow the prescriber’s instructions and the official label.

Storage and Travel Basics

Store tablets in the original packaging at room temperature, away from excessive heat, moisture, and direct light. Keep out of reach of children and pets. Do not store in a bathroom. When traveling, carry the medicine in a hand luggage compartment with a copy of the prescription and the original labeled container. For longer trips, bring extra time for refills and factor in clinic follow-up plans. If traveling across time zones, maintain roughly the same 24-hour interval between doses. Our checkout uses encrypted checkout to help protect personal and payment details.

Benefits

This targeted therapy offers an oral option that fits into daily routines. It may be used across multiple tumor types, including certain neuroendocrine tumors and renal cell carcinoma, and alongside endocrine therapy in select breast cancer cases. The once-daily schedule can simplify adherence. As a class, mTOR inhibitors act on a defined signaling pathway, which differs from cytotoxic chemotherapy and supports a precision approach when indicated.

Side Effects and Safety

• Mouth sores and stomatitis
• Rash or acneiform rash
• Fatigue
• Diarrhea or nausea
• Infections, including respiratory infections
• Cough or shortness of breath
• Peripheral edema
• Headache or dizziness

Serious risks can include non-infectious pneumonitis, severe infections, impaired wound healing, kidney problems, hyperglycemia, dyslipidemia, and hematologic changes. Report new or worsening respiratory symptoms, persistent fever, or severe mouth ulcers to the prescriber. Embryo-fetal toxicity is a known risk; effective contraception is recommended during treatment and for a period after the last dose as directed by the clinician. Do not receive live vaccines during treatment.

Drug Interactions and Cautions

Everolimus is affected by CYP3A4 and P-gp modulators. Strong inhibitors (for example, certain azole antifungals or clarithromycin) can raise levels; strong inducers (such as rifampin or carbamazepine) can lower levels. St. John’s wort should be avoided. ACE inhibitors may increase angioedema risk in combination. Alcohol, high-fat meals, and grapefruit products can alter tolerability or exposure. The prescribing information provides detailed guidance for managing interactions.

What to Expect Over Time

Clinicians typically monitor blood counts, lipids, glucose, and renal function. Imaging and exam schedules are individualized by diagnosis. Mouth soreness often appears early and may improve with supportive care. Some side effects lessen with time as the treatment plan is adjusted. Therapy duration varies, and continuation depends on benefit, tolerability, and clinical judgment. For perspective on targeted therapies used in kidney cancer, see Cabometyx Treatment.

Compare With Alternatives

Other targeted options may be considered based on tumor type and prior therapy. For renal cell carcinoma or certain settings after prior agents, prescribers may consider Cabometyx®. In hormone receptor–positive, HER2-negative breast cancer with a PIK3CA mutation, a prescriber may discuss Piqray® as another path. Choice depends on biomarkers, prior treatments, comorbidities, and safety profiles. Additional reading on immunotherapy options can be found in Bavencio Avelumab.

Pricing and Access

Our platform lists transparent options reflecting Canadian dispensing. For a common query like Afinitor 5 mg price, actual amounts vary by strength, quantity, and pharmacy partner. Everolimus tablets price may differ as market conditions change. Items ship as prescription products and are fulfilled by licensed partners. Ships from Canada to US with tracking.

Check the Cancer category for additional oncology therapies and the origin attribute for Canada if country-of-origin matters for your order. See current seasonal offers on our Promotions page.

Availability and Substitutions

Supply can vary. If a specific strength is temporarily unavailable, a prescriber may adjust the plan or discuss an alternative. When appropriate and available, generic everolimus may be considered as a substitution per the prescription and clinical judgment. For related background on kidney therapies, browse Kidney Cancer. For TSC-related content, see Tuberous Sclerosis.

Patient Suitability and Cost-Saving Tips

People with active infections, poorly controlled diabetes, or significant hepatic impairment need careful evaluation before starting therapy. Those planning surgery generally pause treatment around procedures at the clinician’s direction due to wound healing concerns. Patients of reproductive potential should use effective contraception during therapy and for the recommended time afterward.

Cost-conscious steps can include multi-month supplies when permitted, setting refill reminders to avoid urgent local fills, and aligning lab visits with refill schedules. Discuss supportive care strategies to reduce interruption risk from stomatitis or infections. Patients comparing Canadian options can review condition pages such as Breast Cancer and Pancreatic Neuroendocrine Tumor for broader context.

Questions to Ask Your Clinician

• Treatment goals: what outcomes are realistic for this diagnosis?
• Combination therapy: should it be paired with endocrine treatment in this case?
• Monitoring: what labs and scans are planned during therapy?
• Side effect plan: how to prevent and treat mouth sores?
• Interactions: which medicines or supplements should be avoided?
• Vaccines: are any immunizations recommended before starting?
• Surgery: how should timing be handled around procedures?

Authoritative Sources

Manufacturer Information

FDA Prescribing Information

Health Canada Drug Product Database

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